Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Changuk, Chung"'
Autor:
Eunee Lee, Seungjoon Lee, Jae Jin Shin, Woochul Choi, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park, Min Whan Jung, Se-Bum Paik, Eunjoon Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.
Externí odkaz:
https://doaj.org/article/be579d8154684279867ebaa15847607e
Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice
Autor:
Ye-Eun Yoo, Seungjoon Lee, Woohyun Kim, Hyosang Kim, Changuk Chung, Seungmin Ha, Jinsu Park, Yeonseung Chung, Hyojin Kang, Eunjoon Kim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Shank2 is an excitatory postsynaptic scaffolding protein strongly implicated in autism spectrum disorders (ASDs). Shank2-mutant mice with a homozygous deletion of exons 6 and 7 (Shank2-KO mice) show decreased NMDA receptor (NMDAR) function and autist
Externí odkaz:
https://doaj.org/article/2f1f467b9e434818b3de6732810fdf60
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82124df7eb6da849b6f5f77b50f58f39
https://doi.org/10.1038/s41587-022-01559-w
https://doi.org/10.1038/s41587-022-01559-w
Autor:
Jihye Kim, Hyogeun Shin, Eunjoon Kim, Seung Joon Lee, Young Woo Noh, Tae Kyung Lee, Issac Rhim, Jisoo Kim, Suho Lee, Soo Yeon Lee, Joo Min Park, Ye-Eun Yoo, Seungmin Ha, Min Whan Jung, Karl Deisseroth, Woochul Choi, Woohyun Kim, Ryunhee Kim, Eunee Lee, Il-Joo Cho, Sang Jeong Kim, Changuk Chung, Taesun Yoo, Se-Bum Paik, Jae Jin Shin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here that NMDARs in cortical parvalbumin (Pv)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983dd565722ce47c6e7ebcfbdab7c2e6
https://doaj.org/article/be579d8154684279867ebaa15847607e
https://doaj.org/article/be579d8154684279867ebaa15847607e
Autor:
Andreas Schulze-Bonhage, Xiaoxu Yang, Camila Araújo Bernardino Garcia, Stéphanie Baulac, Martin Werner Breuss, Changuk Chung
Malformations of cortical development (MCD) are neurological conditions displaying focal disruption of cortical architecture and cellular organization arising during embryogenesis, largely from somatic mosaic mutations. Identifying the genetic causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b7e573f5d5bc945d02594dbbe93ba8c
https://doi.org/10.1101/2022.04.07.487401
https://doi.org/10.1101/2022.04.07.487401
Autor:
Aida M. Bertoli-Avella, Paula Monique Leite Pitanga, David M. Virshup, Xiaoxu Yang, Vanessa Wazny, Muznah Khatoo, Karl Willert, Emmanuelle Szenker-Ravi, Nouriya Al-Sannaa, Maria Betânia Pereira Toralles, Trevor Marshall, Zhen Li, Rebecca Hernan, Changuk Chung, Wendy K. Chung, Nhi Lang, Paula Anzenberg, Filippo Mancia, Guoliang Chai, Jia Yu, Bruno Reversade, Rijad Merdzanic, Maha S. Zaki, Joseph G. Gleeson, Ratna Dua Puri, Rie Nygaard, Nan Jiang, Jennifer McEvoy-Venneri, Valentina Stanley, Lu Wang
Publikováno v:
The New England journal of medicine, vol 385, iss 14
N Engl J Med
New England journal of medicine, 385(14), 1292-1301. Massachussetts Medical Society
N Engl J Med
New England journal of medicine, 385(14), 1292-1301. Massachussetts Medical Society
Background Structural birth defects occur in approximately 3% of live births; most such defects lack defined genetic or environmental causes. Despite advances in surgical approaches, pharmacologic prevention remains largely out of reach. Methods We q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dd7a2b833e1f620ac9acc210e49e72
https://escholarship.org/uc/item/61r0j65q
https://escholarship.org/uc/item/61r0j65q
Autor:
Martin W, Breuss, Xiaoxu, Yang, Johannes C M, Schlachetzki, Danny, Antaki, Addison J, Lana, Xin, Xu, Changuk, Chung, Guoliang, Chai, Valentina, Stanley, Qiong, Song, Traci F, Newmeyer, An, Nguyen, Sydney, O'Brien, Marten A, Hoeksema, Beibei, Cao, Alexi, Nott, Jennifer, McEvoy-Venneri, Martina P, Pasillas, Scott T, Barton, Brett R, Copeland, Shareef, Nahas, Lucitia, Van Der Kraan, Yan, Ding, Christopher K, Glass, Soraya, Scuder
Publikováno v:
Nature. 604(7907)
The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs. Here we sought to reconstruct processes that occur during early development by sampling adult human tissues. We analysed neocortical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eabc3df021eb6c4033da5efa77041464
https://pubmed.ncbi.nlm.nih.gov/35444276
https://pubmed.ncbi.nlm.nih.gov/35444276
Autor:
Danny Antaki, Xin Xu, Joseph G. Gleeson, Martin W. Breuss, Alexej Abyzov, Xiaoxu Yang, Laurel L. Ball, Yifan Wang, Chen Li, Changuk Chung, Taejeoing Bae, Renee D. George, Jonathan Sebat
Introductory paragraphMosaic variants (MVs) reflect mutagenic processes during embryonic development1 and environmental exposure2, accumulate with aging, and underlie diseases such as cancer and autism3. The detection of MVs has been computationally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d6a984485f2a909753867cf83718ab
https://doi.org/10.1101/2020.11.14.382473
https://doi.org/10.1101/2020.11.14.382473
Autor:
Xiaoxu, Yang, Xin, Xu, Martin W, Breuss, Danny, Antaki, Laurel L, Ball, Changuk, Chung, Jiawei, Shen, Chen, Li, Renee D, George, Yifan, Wang, Taejeong, Bae, Yuhe, Cheng, Alexej, Abyzov, Liping, Wei, Ludmil B, Alexandrov, Jonathan L, Sebat, Soraya, Scuderi
Publikováno v:
Nature biotechnology.
Mosaic variants (MVs) reflect mutagenic processes during embryonic development and environmental exposure, accumulate with aging and underlie diseases such as cancer and autism. The detection of noncancer MVs has been computationally challenging due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08e2915fcd73f2b2fc657eca493d4f12
https://pubmed.ncbi.nlm.nih.gov/36593400
https://pubmed.ncbi.nlm.nih.gov/36593400
Autor:
Su Yeon Choi, Jason P. Lerch, Won Mah, Hwajin Jung, Yonghan Kwon, Sun-Gyun Kim, Yangsik Kim, Seojung Mo, Eunjoon Kim, Hyun Kim, Mihyun Bae, Issac Rhim, Changuk Chung, Jaeseung Kang, Taesun Yoo, Se-Bum Paik, Hyojin Kang, Hanseul Kweon, Eunee Lee, Seung Min Um, Haram Park, Jiseok Lee, Seungmin Ha, Woochul Choi, Yong Chul Bae, Junyeop Daniel Roh, Jacob Ellegood, Hanwool Park, Yeonsoo Choi
Publikováno v:
Nature Neuroscience. 21:1218-1228
Autism spectrum disorders (ASDs) are four times more common in males than in females, but the underlying mechanisms are poorly understood. We characterized sexually dimorphic changes in mice carrying a heterozygous mutation in Chd8 (Chd8+/N2373K) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4556b8fe9225b09172d374aa3e76708a
https://doi.org/10.1038/s41593-018-0208-z
https://doi.org/10.1038/s41593-018-0208-z