Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Changting Cui"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Hydrostatic pressure, stretch, and shear are major biomechanical forces of vessels and play critical roles in genesis and development of hypertension. Our previous work demonstrated that high hydrostatic pressure (HHP) promoted vascular smooth muscle
Externí odkaz:
https://doaj.org/article/817fa06810934415b2d61f2d953a8dfd
Autor:
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cystathionine gamma-lyase (CSE)/hydrogen sulfide (H2S) plays a protective role in cardiovascular diseases including hypertension and ischemia/reperfusion (I/R) injury. This study was aimed to screen natural small molecule compounds that activate CSE
Externí odkaz:
https://doaj.org/article/bf4527be93ec4a5690a4da4913be4c98
Autor:
Changting Cui, Chuanbo Huang, Kejia Liu, Guoheng Xu, Jichun Yang, Yong Zhou, Yingmei Feng, Georgios Kararigas, Bin Geng, Qinghua Cui
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-7 (2018)
Abstract Background Major differences exist between men and women in both physiology and pathophysiology. Dissecting the underlying processes and contributing mechanisms of sex differences in health and disease represents a crucial step towards preci
Externí odkaz:
https://doaj.org/article/ea555ee9acc5449cbd5692fd5d870073
Autor:
Luyun Fan, Junru Chen, Lili Pan, Xiaohong Xin, Bin Geng, Lirui Yang, Qian Wang, Wenjun Ma, Ying Lou, Jin Bian, Xiao Cui, Jing Li, Lu Wang, Zhenzhen Chen, Wenjie Wang, Changting Cui, Shuangyue Li, Qiannan Gao, Qirui Song, Yue Deng, Jiali Fan, Jiachen Yu, Huimin Zhang, Yafeng Li, Jun Cai
Publikováno v:
Arthritis & Rheumatology. 75:266-278
Mounting evidence has linked microbiome and metabolome to systemic autoimmunity and cardiovascular diseases (CVDs). Takayasu arteritis (TAK) is a rare disease that shares features of immune-related inflammatory diseases and CVDs, about which there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a95554745fe3ff22ee43c83f9000e7e
https://doi.org/10.1002/art.42331
https://doi.org/10.1002/art.42331
Autor:
Xiaoyan Liu, Zhenzhen Chen, Shuangyue Li, Ling Jin, Xiao Cui, Changting Cui, Yue Deng, Qiannan Gao, Luyun Fan, Yaping Niu, Wenjie Wang, Chunmei Cui, Jiuchang Zhong, Qinghua Cui, Bin Geng, Jun Cai
Publikováno v:
International Journal of Biological Sciences. 18:3237-3250
G protein-coupled receptors (GPCRs) are the largest family of druggable targets, and their biological functions depend on different ligands and intracellular interactomes. Some microRNAs (miRNAs) bind as ligands to RNA-sensitive toll-like receptor 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0a3a5d4273d80bbd2a4261170a9ef8
https://doi.org/10.7150/ijbs.70455
https://doi.org/10.7150/ijbs.70455
Autor:
Wenjing Xu, Changting Cui, Chunmei Cui, Zhenzhen Chen, Haizeng Zhang, Qinghua Cui, Guoheng Xu, Jianglin Fan, Yu Han, Liangjie Tang, Giovanni Targher, Christopher D. Byrne, Ming‐Hua Zheng, Liming Yang, Jun Cai, Bin Geng
BACKGROUND AND AIMS: Hydrogen sulfide (H 2 S) plays a protective role in NAFLD. However, whether cystathionine γ lyase (CSE), a dominant H 2 S generating enzyme in hepatocytes, has a role in the pathogenesis of NAFLD is currently unclear. APPROACH A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7941289c8810211a8fdf95f205692cc5
https://eprints.soton.ac.uk/457604/
https://eprints.soton.ac.uk/457604/
Autor:
Shan Jiang, Xiaofang Fan, Zhenzhen Chen, Wenjing Xu, Yongsheng Gong, Changting Cui, Jun Cai, Bin Geng
Publikováno v:
Journal of Cellular and Molecular Medicine
Hyperhomocysteinaemia (HHcy)‐impaired endothelial dysfunction including endoplasmic reticulum (ER) stress plays a crucial role in atherogenesis. Hydrogen sulphide (H2S), a metabolic production of Hcy and gasotransmitter, exhibits preventing cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2a3c096ec5025b71165c94886e5ce4
https://doi.org/10.1111/jcmm.16423
https://doi.org/10.1111/jcmm.16423
Autor:
Haizeng Zhang, Lijun Zhang, Jun Cai, Qiannan Gao, Yan Yang, Shuangyue Li, Qi Wei, Lu Wang, Wenjie Wang, Bai Yingnan, Zhenzhen Chen, Yue Deng, Changting Cui, Bin Geng
Publikováno v:
Science China Life Sciences. 64:1677-1690
Although some co-risk factors and hemodynamic alterations are involved in hypertension progression, their direct biomechanical effects are unclear. Here, we constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efc410161138efc51a0b6031513ea5b
https://doi.org/10.1007/s11427-020-1852-x
https://doi.org/10.1007/s11427-020-1852-x
Autor:
Guoheng Xu, Bin Geng, Jichun Yang, Chaoshu Tang, Wenjie Wang, Jun Cai, Junyan Cai, Shuang yue Li, Zhenzhen Chen, Changting Cui, Yongzeng Chen, Qiang Zeng, Jinghui Fan, Qinghua Cui
Publikováno v:
Circulation. 142:1752-1769
Background: Hydrogen sulfide (H 2 S) has antihypertension and anti-inflammatory effects, and its endogenous-generation key enzyme cystathionine γ lyase (CSE) is expressed in CD4 + T cells. However, the role of CD4 + T-cell endogenous CSE/H 2 S in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b3d4673c8f60c5d4e32c56b18203e0
https://doi.org/10.1161/circulationaha.119.045344
https://doi.org/10.1161/circulationaha.119.045344
Autor:
Zhenzhen Chen, Chenxi Ouyang, Haizeng Zhang, Yuanrui Gu, Yue Deng, Congkuo Du, Changting Cui, Shuangyue Li, Wenjie Wang, Wei Kong, Jingzhou Chen, Jun Cai, Bin Geng
Publikováno v:
Autophagy
Vascular smooth muscle cells (VSMCs) contribute to plaque stability. VSMCs are also a major source of CTH (cystathionine gamma-lyase)-hydrogen sulfide (H2S), a protective gasotransmitter in atherosclerosis. However, the role of VSMC endogenous CTH-H2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562587a32fed509d3d8227e06bbf6f0