Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Changshi Xie"'
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 168:199-207
Serine elastase inhibitors have been proposed as a treatment for cigarette smoke-induced emphysema, but little is known about whether such agents actually are effective. We recently reported that a synthetic serine elastase inhibitor, ZD0892, provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31eefd3b4ee8629c66fa8f4c65349dd5
https://doi.org/10.1164/rccm.200302-203oc
https://doi.org/10.1164/rccm.200302-203oc
Autor:
Joanne L. Wright, Xiaoshan Wang, Jin Dai, Rong D. Wang, Changshi Xie, Andrew Churg, Hsin Tai, Steven D. Shapiro
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 167:1083-1089
The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad1c5744449882f993c62bc259289dc
https://doi.org/10.1164/rccm.200212-1396oc
https://doi.org/10.1164/rccm.200212-1396oc
Autor:
Joanne L. Wright, Katalin Zay, Selena Shay, Changshi Xie, Steven D. Shapiro, Robert L. Hendricks, Andrew Churg
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 27:368-374
The cells/proteases responsible for the development of smoke-induced emphysema is an area of intense investigation. Mice with knockout of macrophage metalloelastase genes (MME(-/-)) do not develop emphysema after smoke exposure, but we also observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f54382fd02d1772dbaf1cd42aa0a7d
https://doi.org/10.1165/rcmb.4791
https://doi.org/10.1165/rcmb.4791
Publikováno v:
Holzforschung. 55:585-589
Summary The fixation reaction of copper-ethanolamine preservatives in wood was studied using the reaction between vanillin, a lignin model compound, and ethanolamine-copper sulphate solution. The green compound precipitated after the reaction has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a361c2c9a93495416a242d7734244abd
https://doi.org/10.1515/hf.2001.095
https://doi.org/10.1515/hf.2001.095
Autor:
Katalin Zay, Stephen Shapiro, Robert L. Martin, Calvin Yee, Rebecca Mackenzie, Richard Hendricks, Changshi Xie, Andrew Churg, Li Zhang, Joanne L. Wright, Jin Dai, Aly Karsan
Publikováno v:
Laboratory Investigation. 81:1119-1131
There is increasing evidence that antiproteases are able to affect the inflammatory response. To further examine this question, we administered human alpha-1-antitrypsin (alpha1AT) or a synthetic metalloprotease inhibitor (RS113456) to C57 mice follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fac3fcdda9387a377c4a78bca0651fc
https://doi.org/10.1038/labinvest.3780324
https://doi.org/10.1038/labinvest.3780324
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 276:L269-L279
Mineral dusts produce emphysema, and administration of dust to rats results in the rapid appearance of desmosine and hydroxyproline in lavage fluid, confirming that dusts directly induce connective tissue breakdown. To examine the role of neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163774e8b7da52820398b58cc188927a
https://doi.org/10.1152/ajplung.1999.276.2.l269
https://doi.org/10.1152/ajplung.1999.276.2.l269
Publikováno v:
hfsg. 49:483-490
A model for the fixation of ammoniacal copper preservatives in wood was examined through reaction of vanillin, a lignin model compound, with ammoniacal copper sulphate solution. The compound produced on evaporation of the aqueous ammoniacal solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86a991e1ce42748623003dfb6bec59f
https://doi.org/10.1515/hfsg.1995.49.6.483
https://doi.org/10.1515/hfsg.1995.49.6.483
Publikováno v:
Toxicology and applied pharmacology. 208(1)
Air pollution particles (PM) are known to elicit an acute inflammatory response in vivo that is mediated in part through PM-induced activation of the NF-kappaB signaling pathway. Many of the details of this process and particularly where in the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f2d710a742f66e9c07fdec55e8a594
https://pubmed.ncbi.nlm.nih.gov/16164960
https://pubmed.ncbi.nlm.nih.gov/16164960
Publikováno v:
American journal of respiratory and critical care medicine. 170(5)
Mice lacking tumor necrosis factor-alpha (TNF-alpha) receptors (TNFRKO mice) do not develop an inflammatory infiltrate or matrix breakdown after a single acute cigarette smoke exposure. To determine the role of TNF-alpha in the long-term development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cb3c2fec7ef85cef197e8d92942451
https://pubmed.ncbi.nlm.nih.gov/15184206
https://pubmed.ncbi.nlm.nih.gov/15184206
Publikováno v:
American journal of respiratory and critical care medicine. 168(10)
Small airway remodeling ("small airways disease") is a common finding in cigarette smokers and is an important cause of airflow obstruction. Airway remodeling is usually attributed to the effects of cigarette smoke-induced inflammation in the airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8992fd7d0c48116e31c319fe3f6db0bd
https://pubmed.ncbi.nlm.nih.gov/12958058
https://pubmed.ncbi.nlm.nih.gov/12958058