Výsledky vyhledávání - "Changshan Sun"

Akademický článek

Preliminary Studies on Liquiritin, Deoxyschizandrin, and Tanshinone II A as Potential Anti-Neurodegenerative Disease Agent: Determination by Reverse-Phase Liquid Chromatography in Tianwang Buxin Pills

Autor: Dan Xu, Sicen Wang, Xiaofang Hou, Changshan Sun

Publikováno v: Journal of Analytical Methods in Chemistry, Vol 2019 (2019)

Tianwang Buxin pill (TWBXP) is an ancient Chinese classic prescription. Liquiritin, deoxyschizandrin, and tanshinone II A are three bioactive components in TWBXP, which have been proven to be closely related to the therapy effect of neurodegenerative

Externí odkaz: https://doaj.org/article/dc008b81006a432384a2d11a40a7838e

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Akademický článek

Synthesis, Crystal Structure, Absolute Configuration and Antitumor Activity of the Enantiomers of 5-Bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide

Autor: Zhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun, Tiemin Sun

Publikováno v: Molecules, Vol 20, Iss 11, Pp 20926-20938 (2015)

Pyridinesulfonamide is an important fragment which has a wide range of applications in novel drugs. R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched. Sin

Externí odkaz: https://doaj.org/article/1ea8a142237b4a759d98620e3c901ddb

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Akademický článek

Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin

Autor: Liang Hu, Changshan Sun, Aihua Song, Di Chang, Xin Zheng, Yikun Gao, Tongying Jiang, Siling Wang

Publikováno v: Asian Journal of Pharmaceutical Sciences, Vol 9, Iss 4, Pp 183-190 (2014)

We applied a combination of inorganic mesoporous silica material, frequently used as drug carriers, and a natural organic polymer alginate (ALG), to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin (IND). Meso

Externí odkaz: https://doaj.org/article/9aae2d8bd8634db0b56d2dd808926101

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Akademický článek

Investigation of Nanosized Crystalline Form to Improve the Oral Bioavailability of Poorly Water Soluble Cilostazol

Autor: Xiaoqing Miao, Changshan Sun, Tongying Jiang, Li Zheng, Tianyi Wang, Siling Wang

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 14, Iss 2 (2011)

Purpose: The aim of this study was to develop cilostazol (CLT) nanocrystals intended to improve its dissolution rate and enhance its bioavailability. Methods: In this study, CLT nanosuspension was prepared by the anti-solvent and high-pressure homoge

Externí odkaz: https://doaj.org/article/54ae4b0253b34e05818c4272e9733d4c

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Akademický článek

Mechanism of Dissolution Enhancement and Bioavailability of Poorly Water Soluble Celecoxib by Preparing Stable Amorphous Nanoparticles

Autor: Yinghui Liu, Changshan Sun, Yanru Hao, Tongying Jiang, Li Zheng, Siling Wang

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 4 (2010)

Purpose: Nanoparticle engineering offers promising methods for the formulation of poorly water soluble drug compounds. The aim of the present work was to enhance dissolution and oral bioavailability of poorly water-soluble celecoxib (CXB) by preparin

Externí odkaz: https://doaj.org/article/31891d1c8d19466aaf9dd042db85a2eb

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Construction and Evaluation of Traceable rhES-QDs-M-MS Protein Delivery System: Sustained-Release Properties, Targeted Effect, and Antitumor Activity

Autor: Xiaowen, Wu, Yi, Zou, Kunyu, Du, Yi, Du, Caleb Kesse, Firempong, Yang, Yu, Haibing, He, Hongfei, Liu, Changshan, Sun

Publikováno v: AAPS PharmSciTech. 23

Recombinant human endostatin (rhES) is a protein drug with poor stability and short in vivo circulation time. The present study was therefore aimed at developing sustained-release lung targeted microspheres drug delivery system and evaluating its tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9db4ec689311429e4dbe37b38760be
https://doi.org/10.1208/s12249-022-02326-5

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Preparation and Evaluation of rhINF-α-2b Sodium Hyaluronate Cross-Linked Porous Microspheres: Characterization, Sustained-Release Properties, and Antitumor Activity

Autor: Hongfei, Liu, Yi, Zou, Jie, Zhu, Haibing, He, Yingshu, Feng, Caleb Kesse, Firempong, Yang, Yu, Changshan, Sun

Publikováno v: AAPS PharmSciTech. 23

Recombinant human interferon α-2b (rhINF-α-2b), like most proteins, has several shortcomings such as relatively short half-life, low therapeutic index, high circulating drug fluctuations, and rapid degradation which could hinder its effective deliv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82efe54d8c14192810f9d836b6d5f4ff
https://doi.org/10.1208/s12249-021-02178-5

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