Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Changrim Lee"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6157 (2020)
Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1. The pre
Externí odkaz:
https://doaj.org/article/fefea4a1f9a44e5787b61562baff69f9
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 221 (2019)
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye. This manuscript explores a novel strategy to drive the reversible adsorption of peptide-base
Externí odkaz:
https://doaj.org/article/3c9bfe41a1f241b0ade1e7bd22776309
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123865 (2015)
PHF8 is a JmjC domain-containing histone demethylase, defects in which are associated with X-linked mental retardation. In this study, we examined the roles of two PHF8 homologs, JMJD-1.1 and JMJD-1.2, in the model organism C. elegans in response to
Externí odkaz:
https://doaj.org/article/0a9b1f67792d443fa2baca63ca032bd8
Publikováno v:
Adv Drug Deliv Rev
Antibodies possess multiple biologically relevant features that have been engineered into new therapeutic formats. Two examples include the adaptable specificity of their variable (Fv) region and the extension of plasma circulation times through thei
Autor:
Hanyeoreum Bae, Miryeong Kwon, Donghyun Gouk, Sanghyun Han, Sungjoon Koh, Changrim Lee, Dongchul Park, Myoungsoo Jung
Publikováno v:
2021 IEEE 39th International Conference on Computer Design (ICCD).
Autor:
Santosh Peddi, J. Andrew MacKay, Sarah F. Hamm-Alvarez, Changrim Lee, Stan G. Louie, Frances Yarber, Srikanth Reddy Janga, Siyu Liu, Wannita Klinngam, Nishant Tiwari, Hao Guo, Maria C. Edman
Publikováno v:
Mol Pharm
The USFDA-approved immunosuppressive drug rapamycin (Rapa), despite its potency, is limited by poor bioavailability and a narrow therapeutic index. In this study, we sought to improve bioavailability of Rapa with subcutaneous (SC) administration and
Autor:
Mihir Shah, Sarah F. Hamm-Alvarez, J. Andrew MacKay, Hao Guo, Changrim Lee, Maria C. Edman, Srikanth Reddy Janga, Wannita Klinngam
Publikováno v:
Journal of Controlled Release. 292:183-195
As a potent macrolide immunosuppressant, cyclosporine A (CsA) is used to treat multiple autoimmune diseases, including non-autoimmune and autoimmune-mediated dry eye disease, rheumatoid arthritis and psoriasis. Despite its potency, CsA has poor solub
Publikováno v:
IISWC
Emerging storage systems with new flash exhibit ultra-low latency (ULL) that can address performance disparities between DRAM and conventional solid state drives (SSDs) in the memory hierarchy. Considering the advanced low-latency characteristics, di
Autor:
Hao Guo, Srikanth Reddy Janga, Frances Yarber, Dandan Wang, Yaping Ju, Changrim Lee, Maria C. Edman, Sarah F. Hamm-Alvarez, Wannita Klinngam, J. Andrew MacKay, Mihir Shah
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Cathepsin S (CTSS) is highly increased in Sjögren’s syndrome (SS) patients tears and in tears and lacrimal glands (LG) of male non-obese diabetic (NOD) mice, a murine model of SS. To explore CTSS’s utility as a therapeutic target for mitigating
Autor:
Hao Su, Alan L. Epstein, Santosh Peddi, Honggang Cui, Changrim Lee, J. Andrew MacKay, Caleb F. Anderson
Publikováno v:
Biomaterials
Despite advancements in antibody-based therapies for non-Hodgkin lymphoma (NHL), at least two major therapeutic needs remain unmet: i) heterogenous activation of host immunity towards B cell NHL; and ii) lack of antibody-based therapeutics for T cell