Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Changning, Wang"'
Publikováno v:
ACS Omega, Vol 9, Iss 34, Pp 36177-36184 (2024)
Externí odkaz:
https://doaj.org/article/a21073303e004dd6b741479c84201bc3
Autor:
Ping Bai, Yu Lan, Yan Liu, Prasenjit Mondal, Ashley Gomm, Yulong Xu, Yanli Wang, Yongle Wang, Leyi Kang, Lili Pan, Frederick A. Bagdasarian, Madelyn Hallisey, Fleur Lobo, Breanna Varela, Se Hoon Choi, Stephen N. Gomperts, Hsiao‐Ying Wey, Shiqian Shen, Rudolph E. Tanzi, Changning Wang, Can Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Targeting receptor‐interacting protein kinase 1 (RIPK1) has emerged as a promising therapeutic stratagem for neurodegenerative disorders, particularly Alzheimer's disease (AD). A positron emission tomography (PET) probe enabling brain RIPK
Externí odkaz:
https://doaj.org/article/6a95c45a9c77468596a655055eef9238
Autor:
Tewodros Mulugeta Dagnew, Chieh-En J. Tseng, Chi-Hyeon Yoo, Meena M. Makary, Anna E. Goodheart, Robin Striar, Tyler N. Meyer, Anna K. Rattray, Leyi Kang, Kendall A. Wolf, Stephanie A. Fiedler, Darcy Tocci, Hannah Shapiro, Scott Provost, Eleanor Sultana, Yan Liu, Wei Ding, Ping Chen, Marek Kubicki, Shiqian Shen, Ciprian Catana, Nicole R. Zürcher, Hsiao-Ying Wey, Jacob M. Hooker, Roger D. Weiss, Changning Wang
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110159- (2024)
Summary: Alcohol use disorder (AUD) is a disorder of clinical and public health significance requiring novel and improved therapeutic solutions. Both environmental and genetic factors play a significant role in its pathophysiology. However, the under
Externí odkaz:
https://doaj.org/article/103a05e692354997b207d886b6310c5d
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1289 (2024)
Background/Objectives: Small molecules that interfere with the interaction between acetylated protein tails and the tandem bromodomains of BET (bromodomain and extra-terminal) family proteins are pivotal in modulating immune/inflammatory and neoplast
Externí odkaz:
https://doaj.org/article/91c73b6b1b844009ae277761d65014c7
Autor:
Zude Chen, Xiaoshuang Yang, Zugen Chen, Minzhao Li, Wei Wang, Riwei Yang, Zuomin Wang, Yuxiang Ma, Yulong Xu, Shan Ao, Leqi Liang, Chao Cai, Changning Wang, Tuo Deng, Di Gu, Hongqing Zhou, Guohua Zeng
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor microenvironment (TME)
Externí odkaz:
https://doaj.org/article/8172630b3a68414aab193319f3c377d9
Autor:
Weihua Ding, Liuyue Yang, Eleanor Shi, Bowon Kim, Sarah Low, Kun Hu, Lei Gao, Ping Chen, Wei Ding, David Borsook, Andrew Luo, Jee Hyun Choi, Changning Wang, Oluwaseun Akeju, Jun Yang, Chongzhao Ran, Kristin L. Schreiber, Jianren Mao, Qian Chen, Guoping Feng, Shiqian Shen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to
Externí odkaz:
https://doaj.org/article/0a4619c458044cdda3673eb069cd8205
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-9 (2023)
Abstract Background Citrus tristeza virus (CTV) is one of the most serious threats to the citrus industry, and is present in both wild and cultivated citrus. The origin and dispersal patterns of CTV is still poorly understood in China. Methods In thi
Externí odkaz:
https://doaj.org/article/77a12570cc6547c19bc205e57056aa59
Autor:
Prasenjit Mondal, Ping Bai, Ashley Gomm, Grisilda Bakiasi, Chih‐Chung Jerry Lin, Yanli Wang, Se Hoon Choi, Rudolph E. Tanzi, Changning Wang, Can Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Histone deacetylase 6 (HDAC6) is one of the key histone deacetylases (HDACs) that regulates various cellular functions including clearance of misfolded protein and immunological responses. Considerable evidence suggests that HDAC6 is closely
Externí odkaz:
https://doaj.org/article/dc1603e8e7de47d08dce3a1227f667ad
Autor:
Gaofeng Zhu, Ping Bai, Keren Wang, Jing Mi, Jing Yang, Jiaqi Hu, Yujuan Ban, Ran Xu, Rui Chen, Changning Wang, Lei Tang, Zhipei Sang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1375-1388 (2022)
Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly
Externí odkaz:
https://doaj.org/article/07a7106afbb742a6a7d8949e0658f002
Autor:
Ping Bai, Prasenjit Mondal, Frederick A. Bagdasarian, Nisha Rani, Yan Liu, Ashley Gomm, Darcy R. Tocci, Se Hoon Choi, Hsiao-Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 10, Pp 3891-3904 (2022)
Although the epigenetic regulatory protein histone deacetylase 6 (HDAC6) has been recently implicated in the etiology of Alzheimer's disease (AD), little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potent
Externí odkaz:
https://doaj.org/article/fd064ae82b114df3b5e13bbc54ea4e17