Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Changmai, Chen"'
Autor:
Changmai Chen, Maocheng Yu, Qing Li, Ying Zhou, Mengting Zhang, Shanyu Cai, Jiaojiao Yu, Zhongnan Huang, Jiaan Liu, Ye Kuang, Xinjing Tang, Wei Chen
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Multidrug resistance (MDR) is a major obstacle limiting the effectiveness of chemotherapy against cancer. The combination strategy of chemotherapeutic agents and siRNA targeting drug efflux has emerged as an effective cancer treatment to ove
Externí odkaz:
https://doaj.org/article/5c847781cd234ccf8c6ac22d33f37ebb
Autor:
Wei Zhang, Zhou Sha, Yunzhe Tang, Cuiyuan Jin, Wenhua Gao, Changmai Chen, Lang Yu, Nianyin Lv, Shijia Liu, Feng Xu, Dandan Wang, Liyun Shi
Publikováno v:
Advanced Science, Vol 11, Iss 22, Pp n/a-n/a (2024)
Abstract Despite accumulating evidence linking defective lysosome function with autoimmune diseases, how the catabolic machinery is regulated to maintain immune homeostasis remains unknown. Late endosomal/lysosomal adaptor, MAPK and mTOR activator 5
Externí odkaz:
https://doaj.org/article/c101069404344d80bd6c11480fdf2e4b
Autor:
Liangliang Zhang, Duanwei Liang, Changmai Chen, Yuan Wang, Gubu Amu, Jiali Yang, Lijia Yu, Ivan J. Dmochowski, Xinjing Tang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 237-244 (2018)
Circular non-coding RNAs are found to play important roles in biology but are still relatively unexplored as a structural motif for chemically regulating gene function. Here, we investigated whether small interfering RNA (siRNA) with a circular struc
Externí odkaz:
https://doaj.org/article/7b069acb5ffb4ce4841d0debe1a4898d
Autor:
Cheng Cheng, Peng Ji, Tonghui Ma, Xiaohui Wu, Changmai Chen, Nianyin Lv, Zhou Sha, Haibo Cheng, Chengtao Yu, Wei Zhang, Liyun Shi
Publikováno v:
Free Radical Biology and Medicine. 168:247-257
Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial pneumonia, featured with exuberant inflammatory cytokine production, extensive oxidative stress and tissue injury. The Keap1/Nrf2 system is the major apparatus essen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99090b3358c30308bee5e401ceafbe75
https://doi.org/10.1016/j.freeradbiomed.2021.03.038
https://doi.org/10.1016/j.freeradbiomed.2021.03.038
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:394-409
Salsalate, an ester formed by 2 salicylic acid molecules, has beneficial effect against metabolic disorders in clinical trials and in animal studies. This study focused on the mechanistic aspects of salsalate activity against non-alcoholic fatty live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b23e9c5df2b8faeac53e69c422e64d
https://doi.org/10.1111/bcpt.13535
https://doi.org/10.1111/bcpt.13535
Publikováno v:
ChemPhotoChem. 5:12-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a83b0fb4f53bb5be6466d1426c1dea9a
https://doi.org/10.1002/cptc.202000220
https://doi.org/10.1002/cptc.202000220
Publikováno v:
Chemical Science. 11:12289-12297
We rationally designed and developed caged siRNA nanoparticles (Multi-Chol-siRNA) self-assembled with cholesterol-modified multimerized caged siRNAs for photomodulation of siRNA gene silencing activity. Strong resistance to serum nuclease and RNase A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdff41ffe6131114db7cc2faad946c7f
https://doi.org/10.1039/d0sc03562a
https://doi.org/10.1039/d0sc03562a
Publikováno v:
Chemical Science
We rationally designed and developed caged siRNA nanoparticles (Multi-Chol-siRNA) self-assembled with cholesterol-modified multimerized caged siRNAs for photomodulation of siRNA gene silencing activity. Strong resistance to serum nuclease and RNase A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::645a5e2e32f67c620eef0190c45af9be
https://pubmed.ncbi.nlm.nih.gov/34094437
https://pubmed.ncbi.nlm.nih.gov/34094437
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2115
We designed and synthesized caged siRNAs with photolabile linker and single cRGD peptide modifications for the photoregulation of gene expression. Photolabile linker and cRGD were inserted at 5' terminus of siRNAs to obtain cRGD-modified caged siRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b0ee231273164e5a2f10b0ae7cb961c
https://pubmed.ncbi.nlm.nih.gov/32006399
https://pubmed.ncbi.nlm.nih.gov/32006399
Publikováno v:
RNA Interference and CRISPR Technologies ISBN: 9781071602898
We designed and synthesized caged siRNAs with photolabile linker and single cRGD peptide modifications for the photoregulation of gene expression. Photolabile linker and cRGD were inserted at 5' terminus of siRNAs to obtain cRGD-modified caged siRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e044404e0353400bd5e9366aabcd46
https://doi.org/10.1007/978-1-0716-0290-4_8
https://doi.org/10.1007/978-1-0716-0290-4_8
