Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Changkyu Gu"'
Autor:
Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen, Beata Samelko, Mehmet M. Altintas, Yashwanth R. Sudhini, Xuexiang Wang, Richard Bouley, Dennis Brown, Bradley P. Pedro, Susan L. Bane, Vineet Gupta, Paul T. Brinkkoetter, Henning Hagmann, Jochen Reiser, Sanja Sever
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in
Externí odkaz:
https://doaj.org/article/de985803365d4a178cb549392c2a5749
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
EphA2/ErbB2 complex is important in promoting breast cancer but the mechanism by which these receptor tyrosine kinases are exported from the endoplasmic reticulum is unknown. Here the authors show that Anks1a acts as a cargo adaptor in sorting EphA2
Externí odkaz:
https://doaj.org/article/414a168e7d8b4e848a820339ce79c82f
Autor:
Ke Zhu, Kamalika Mukherjee, Changli Wei, Salim S. Hayek, Agnieszka Collins, Changkyu Gu, Kristin Corapi, Mehmet M. Altintas, Yong Wang, Sushrut S. Waikar, Antonio C. Bianco, Jochen Reiser, Sanja Sever
Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk factor for kidney diseases. Here we report the presence of C-terminal suPAR fragment, D2D3, in patients with diabetic nephropathy. D2D3-positive human sera inhibited glucose-stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98f06c311add47f552f00e152c89354
https://doi.org/10.1101/2022.04.26.489589
https://doi.org/10.1101/2022.04.26.489589
Autor:
Jochen Reiser, Samy Hakroush, Changli Wei, Faikah Gueler, Nicholas J. Tardi, Hermann Haller, Chuang Chen, Lynne Staggs, Joon Keun Park, Sergej Erschow, Valentina A. Shchedrina, Nils Hanke, Vincent A. Pham, Martin K. Selig, Mario Schiffer, Marina V. Kasaikina, Beina Teng, Irini Tossidou, Aleksandr Vasilyev, Patricia Schroder, Changkyu Gu, Sanja Sever, Song Rong, Denise Hilfiker-Kleiner, Sandra Merscher
Publikováno v:
Nature Medicine. 21:601-609
Dysregulation of the actin cytoskeleton in podocytes represents a common pathway in the pathogenesis of proteinuria across a spectrum of chronic kidney diseases (CKD). The GTPase dynamin has been implicated in the maintenance of cellular architecture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c46d2b2e0b475d57fbc844a0016357
https://doi.org/10.1038/nm.3843
https://doi.org/10.1038/nm.3843
Autor:
Bradley T. Hyman, Brian J. Bacskai, William Lehman, John H. Hartwig, Joann Chang, Valentina A. Shchedrina, Sanja Sever, Vincent A. Pham, Worawit Suphamungmee, Changkyu Gu
Publikováno v:
Traffic. 15:819-838
Dynamin is a 96 kDa protein that has multiple oligomerization states that influence its GTPase activity. A number of different dynamin effectors, including lipids, actin filaments, and SH3-domain containing proteins, have been implicated in the regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b670b345f24c55f0581ff237bb3ca2
https://doi.org/10.1111/tra.12178
https://doi.org/10.1111/tra.12178
Autor:
Phillip Ruiz, Dontscho Kerjaschki, Changkyu Gu, Hao Yu, Sandeep Kumar Srivastava, Amit K. Dinda, Stuart E. Dryer, Geetika Singh, Sanja Sever, Christian Faul, Cory Wilson, Andreas D. Kistler, Jochen Reiser, Isabel Fernandez, Mehmet M. Altintas, Katherina Walz, Alexander Dietrich
Publikováno v:
Journal of Biological Chemistry. 288:36598-36609
Gain-of-function mutations in the calcium channel TRPC6 lead to autosomal dominant focal segmental glomerulosclerosis and podocyte expression of TRPC6 is increased in some acquired human glomerular diseases, particularly in membranous nephropathy. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6acb3623c548991b8e0c16a0c60f75
https://doi.org/10.1074/jbc.m113.488122
https://doi.org/10.1074/jbc.m113.488122
Autor:
Changkyu Gu1, Sungbo Shim1,2, Jongdae Shin1,2, Jieun Kim3, Jonghoon Park3, Kyuhyung Han2, Soochul Park3 separk@sookmyung.ac.kr
Publikováno v:
Oncogene. 6/16/2005, Vol. 24 Issue 26, p4243-4256. 14p.
Publikováno v:
Traffic (Copenhagen, Denmark)
The GTPase dynamin has captivated researchers for over two decades, even managing to establish its own research field. Dynamin's allure is partly due to its unusual biochemical properties as well as its essential role in multiple cellular processes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518894c927c14a861a423fa9afd3ea1a
http://europepmc.org/articles/PMC3830594
http://europepmc.org/articles/PMC3830594
Publikováno v:
Journal of the American Society of Nephrology : JASN. 28(2)
Rho family GTPases, the prototypical members of which are Cdc42, Rac1, and RhoA, are molecular switches best known for regulating the actin cytoskeleton. In addition to the canonical small GTPases, the large GTPase dynamin has been implicated in regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b272283a05d122fcc48c514dad853b86
https://pubmed.ncbi.nlm.nih.gov/27432739
https://pubmed.ncbi.nlm.nih.gov/27432739
Autor:
Changli Wei, Wenjun Ju, Anna-Lena Forst, Tobias B. Huber, Andreas D. Kistler, Suma Yaddanapudi, Clemens C. Möller, Zhijie Xiao, Jochen Reiser, Tobias Lohmüller, Maria Pia Rastaldi, Christian Faul, Mario Schiffer, Jan Flesche, Markus Bitzer, Jaakko Patrakka, Mehmet M. Altintas, Isabel Fernandez, Karl Tryggvason, Florian Grahammer, Andrey S. Shaw, Phillip Ruiz, Vasil Peev, Thomas Reinheckel, Sanja Sever, Changkyu Gu, Jing Li
Publikováno v:
Europe PubMed Central
The Journal of clinical investigation
The Journal of clinical investigation
Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte injury results in proteinuric kidney disease, and genetic deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b692e8ddd8b40ce41288b21b414a4c
https://doi.org/10.1172/jci58552
https://doi.org/10.1172/jci58552