Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Changhua Ji"'
Autor:
Gengshen Yin, Liyuan Liu, Ting Yu, Lixiang Yu, Man Feng, Chengjun Zhou, Xiaoying Wang, Guoxin Teng, Zhongbing Ma, Wenzhong Zhou, Chunmiao Ye, Jialin Zhang, Changhua Ji, Linfeng Zhao, Peng Zhou, Yaxun Guo, Xingchen Meng, Qinye Fu, Qiang Zhang, Liang Li, Fei Zhou, Chao Zheng, Yujuan Xiang, Mingming Guo, Yongjiu Wang, Fei Wang, Shuya Huang, Zhigang Yu
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Neoadjuvant chemotherapy (NAC) has become a standard treatment strategy for breast cancer (BC). However, owing to the high heterogeneity of these tumors, it is unclear which patient population most likely benefit from NAC. Multi-o
Externí odkaz:
https://doaj.org/article/2c32e898efe14956bd40571967a03fce
Autor:
Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298240 (2024)
PF-07209960 is a novel bispecific fusion protein composed of an anti-PD-1 antibody and engineered IL-15 cytokine mutein with reduced binding affinity to its receptors. The pharmacokinetics (PK), pharmacodynamics (PD), and toxicity of PF-07209960 were
Externí odkaz:
https://doaj.org/article/c39ae2f51f884dbb9d5bbfa5463a5364
Autor:
Timothy Affolter, Heather P Llewellyn, Derek W Bartlett, Qing Zong, Shuhua Xia, Vince Torti, Changhua Ji
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217276 (2019)
Cancer cells harness immune checkpoints such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase 1 (IDO1) to evade immune control. Checkpoint inhibitors have demonstrated dur
Externí odkaz:
https://doaj.org/article/e97358d427054704baa64ad8ebcb427c
Autor:
Benny Chain, Jack Arnold, Samia Akthar, Michael Brandt, David Davis, Mahdad Noursadeghi, Thabo Lapp, Changhua Ji, Surya Sankuratri, Yanjing Zhang, Lata Govada, Emmanuel Saridakis, Naomi Chayen
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128381 (2015)
The CCR5 receptor plays a role in several key physiological and pathological processes and is an important therapeutic target. Inhibition of the CCR5 axis by passive or active immunisation offers one very selective strategy for intervention. In this
Externí odkaz:
https://doaj.org/article/2d4e5a257247431cb2a36a05fa62c086
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Table S1. Mean ({plus minus}SD) Toxicokinetic Parameters for Ipilimumab and Novolumab in Cynomolgus Monkeys Table S2 - Differentially expressed genes in the heart of ipilimumab and nivolumab treated cynos (adjusted P-value {less than or equal to} 0.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942b4f23d29af0107356ea8a8bc653c
https://doi.org/10.1158/1078-0432.22469919.v1
https://doi.org/10.1158/1078-0432.22469919.v1
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Supplemental Figure S1. Concentration versus time profiles of ipilimumab and nivolumab following four weekly intravenous dose administrations of 15 mg/kg or 20 mg/kg, respectively. Supplementary Figure S2. Hematoxylin and eosin stained sections of ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027a7f5962acdd0744c93d4421f906a4
https://doi.org/10.1158/1078-0432.22469916
https://doi.org/10.1158/1078-0432.22469916
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Purpose:Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocardit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5055934097852ef3af9d150157463861
https://doi.org/10.1158/1078-0432.c.6527388
https://doi.org/10.1158/1078-0432.c.6527388
Autor:
Ivana Djuretic, Dave Tsao, Yuanming Xu, Lucia Campos Carrascosa, Gabriel R. Starbeck-Miller, Valeska de Ruiter, Wenjing Yang, Javier Chaparro-Riggers, Zhouhong Ge, Changhua Ji, Tina Mistry, Jaap Kwekkeboom, Lidia Mosyak, John Zeytounian, Matthew Ling-Hon Chu, Renny Feldman, Lisanne Noordam, Eugenia Kraynov, Tzu-Hsuan Huang, Martin E. van Royen, Diamanda Rigas, Sherman M. Chin, Irene Ni, Dave Sprengers, Shih-Hsun Chen, Danielle Pappas, Kevin Lindquist, Michael Doukas, Patrick P.C. Boor, Joanne Verheij, Keith A. Ching, Magdalena Dorywalska, Luz Marina Londono, Joris I. Erdmann, Dirk J. Grünhagen, Laura Lin, Bing Kuang, Jan N. M. IJzermans, Yik Andy Yeung, James Patterson, Jie Guo, Salah Mahmoudi, Terrence Park, Pascal G. Doornebosch, Robert C Rickert
Publikováno v:
Cancer Immunology Research, 9(10), 1141-1157. American Association for Cancer Research Inc.
Cancer immunology research, 9(10), 1141-1157. American Association for Cancer Research Inc.
Cancer immunology research, 9(10), 1141-1157. American Association for Cancer Research Inc.
The use of cytokines for immunotherapy shows clinical efficacy but is frequently accompanied by severe adverse events caused by excessive and systemic immune activation. Here, we set out to address these challenges by engineering a fusion protein of
Publikováno v:
Proceedings of the 8th International Conference on Computing and Artificial Intelligence.
Autor:
Allison Vitsky, Nasir K. Khan, Frank Barletta, Jonathan Golas, Changhua Ji, Steven W. Kumpf, Bernard S. Buetow, Andrea T. Hooper, Puja Sapra, Sripad Ram, Magali Guffroy, William A. Meier, Martin Finkelstein, Matthew Martin, Marc D. Roy
Publikováno v:
Clinical Cancer Research. 25:4735-4748
Purpose: Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocardi