Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Changhu Lee"'
Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia
Autor:
Changhu Lee, Min Kim, Chanho Park, Woobeen Jo, Jeong Kon Seo, Sahee Kim, Jiyoung Oh, Chu-Sook Kim, Han Suk Ryu, Kyung-Hun Lee, Jiyoung Park
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Despite hyperglycemia has been associated to breast cancer, the underlying mechanisms are not completely understood. Here, the authors show that epigenetic regulation of Nrg1 gene during hyperglycemia promotes breast cancer development.
Externí odkaz:
https://doaj.org/article/70307856217b44f6a9332ad61e67b385
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Breast cancer is one of the most common cancers in women and is associated with a high mortality rate. The majority of deaths resulting from breast cancer are attributable to metastatic growth; in addition, chemoresistance is a major concern
Externí odkaz:
https://doaj.org/article/4c04b9f1f738472281baa399332239d9
Autor:
Min Kim, Changhu Lee, Dae Yun Seo, Hyojung Lee, Jay D. Horton, Jiyoung Park, Philipp E. Scherer
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1766-1776 (2020)
Liver disease: Collagen fragment spurs liver inflammation and fibrosis Localized buildup in the liver of a collagen-derived cleavage fragment plays a critical role in accelerating the development of tissue scarring and liver cancer in mice. Using a t
Externí odkaz:
https://doaj.org/article/e8c15da804804675993b7404515a3f3a
Publikováno v:
Trends in Cell Biology. 32:825-834
Obesity, a global public health concern, is an important risk factor for metabolic diseases and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with the pathologies of obesity; excessive or uncontrolled extracellula
Autor:
Woobeen Jo, Min Kim, Jiyoung Oh, Chu-Sook Kim, Chanho Park, Sora Yoon, Changhu Lee, Sahee Kim, Dougu Nam, Jiyoung Park
Dysregulation of extracellular matrix proteins in obese adipose tissue (AT) induces systemic insulin resistance. The metabolic roles of type VI collagen and its cleavage peptide endotrophin in obese AT are well established. However, the mechanisms re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcadb60c488fcfb0009242c777f75e9d
https://doi.org/10.2337/figshare.19149275.v1
https://doi.org/10.2337/figshare.19149275.v1
Autor:
Jiyoung Park, Changhu Lee, Dae Yun Seo, Philipp E. Scherer, Min Kim, Hyojung Lee, Jay D. Horton
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1766-1776 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and can lead to multiple complications, including non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. The fibrotic liver is characterized by the pat
Autor:
Jang Hyun Choi, Sang Min Lee, Jun Ho Lee, Philipp E. Scherer, Min Kim, Hyun Hee Shin, Jiyoung Oh, Jiyoung Park, Changhu Lee, Hyug Moo Kwon
Publikováno v:
The Journal of Pathology. 247:99-109
Extracellular matrix dysregulation is associated with chronic liver disease. CollagenVI-alpha3 chain (COL6A3) is a biomarker for hepatic fibrosis and poor prognosis of hepatocellular carcinoma (HCC), but its function in liver pathology remains unknow
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Breast cancer is one of the most common cancers in women and is associated with a high mortality rate. The majority of deaths resulting from breast cancer are attributable to metastatic growth; in addition, chemoresistance is a major concern in the t
Autor:
Jiyoung Park, Changhu Lee, Woo Gyeong Kim, Heunglae Cho, Tae Hyun Kim, Ki Jung Ahn, Yunseon Choi, Anbok Lee, Sung-Kwang Park, Hye-Kyoung Yoon, Sunmi Jo, Hyun-Hee Shin
Publikováno v:
Breast cancer (Tokyo, Japan). 26(5)
Recent studies revealed that metabolic stress influences the outcomes of breast cancer treatment. We sought to evaluate the prognostic effect of type 2 diabetes and find the molecular mechanism of relapses in postoperative HER-2+ breast cancer patien
Autor:
Changhu, Lee, Min, Kim, Jun Ho, Lee, Jiyoung, Oh, Hyun-Hee, Shin, Sang Min, Lee, Philipp E, Scherer, Hyug Moo, Kwon, Jang Hyun, Choi, Jiyoung, Park
Publikováno v:
The Journal of pathology. 247(1)
Extracellular matrix dysregulation is associated with chronic liver disease. CollagenVI-alpha3 chain (COL6A3) is a biomarker for hepatic fibrosis and poor prognosis of hepatocellular carcinoma (HCC), but its function in liver pathology remains unknow