Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Changhan Ouyang"'
Autor:
Ying Su, Aimei Liu, Hongguang Chen, Qingjie Chen, Bo Zhao, Runze Gao, Kangwei Zhang, Tie Peng, Zhenwang Zhang, Changhan Ouyang, Dan Zhu
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of
Externí odkaz:
https://doaj.org/article/64945afa33304cbda9399da8521ba339
Autor:
Qiaofeng Zhou, Xiying Guo, Tu Chen, Yumin Liu, Huimin Ji, Yixuan Sun, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Min Lei
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117397- (2024)
Celastrol, the primary constituent of Tripterygium wilfordii, has demonstrated neuroprotective properties in rats with dementia by reducing inflammation. A high-fat diet and streptozotocin injection were utilized to establish a diabetic rat model, wh
Externí odkaz:
https://doaj.org/article/5da03d17743543df83e769ac802330f7
Autor:
Shihuan Li, Qingjie Li, Qiaofeng Zhou, Suqin Li, Siqi Wang, Qing Yao, Changhan Ouyang, Chao Liu, Mincai Li
Publikováno v:
Cardiovascular Therapeutics, Vol 2024 (2024)
Objective. We investigated the effects of resveratrol (Res) and MCC950 on the pyroptosis of vascular smooth muscle cells (VSMCs) and the potential pathway. Methods and Results. Compared with the control (Con) group, the atherosclerosis (AS) group sho
Externí odkaz:
https://doaj.org/article/0440fc1e51f4437fbee5a7e874857b73
Autor:
Yuting Yuan, Yue Zhang, Min Lei, Xiying Guo, Xiaosong Yang, Changhan Ouyang, Chao Liu, Qingjie Chen
Publikováno v:
International Journal of Endocrinology, Vol 2024 (2024)
Purpose. Type 2 diabetes mellitus is considered as one of the risk factors for cognitive impairment. DPP4 inhibitors are effective drugs for the treatment of type 2 diabetes mellitus. However, the relationship between DPP4 inhibitors and cognitive dy
Externí odkaz:
https://doaj.org/article/21d11aaabe5c407f81b88f228faa4055
Identification of key genes and pathways in atherosclerosis using integrated bioinformatics analysis
Autor:
Shihuan Li, Suqin Li, Qingjie Li, Qiaofeng Zhou, Wenli Liao, Liangzhu Yu, Changhan Ouyang, Hongli Xia, Chao Liu, Mincai Li
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background Atherosclerosis (AS) is a chronic inflammatory disease that might induce severe cardiovascular events, such as myocardial infarction and cerebral infarction. These risk factors in the pathogenesis of AS remain uncertain and furthe
Externí odkaz:
https://doaj.org/article/f6a840995aef45fea75ef1c2c3224dd9
Autor:
Min Lei, Xiying Guo, Yue Yao, Ting Shu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Qingjie Chen, Chao Liu, Xiufen Liu
Publikováno v:
Experimental Gerontology, Vol 182, Iss , Pp 112307- (2023)
Cognitive impairment frequently coexists with diabetes. Trelagliptin is a once-weekly taking selective dipeptidyl peptidase-4 (DPP-4) inhibitor and a long-term effective hypoglycemic medicine; nonetheless, its effects for the treatment of diabetes-re
Externí odkaz:
https://doaj.org/article/1a5ea646e289413fbf2c0f9d1f340fcf
Autor:
Xiying Guo, Min Lei, Jiangyan Zhao, Min Wu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Chao Liu, Qingjie Chen
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: One of the typical symptoms of diabetes mellitus patients was memory impairment, which was followed by gradual cognitive deterioration and for which there is no efficient treatment. The anti-diabetic incretin hormones glucose-dependent in
Externí odkaz:
https://doaj.org/article/e3497a9a50f949fd9b3ecb1e3f5736fe
Autor:
Suqin Li, Shihuan Li, Qingjie Li, Fei Liu, Wenli Liao, Liangzhu Yu, Changhan Ouyang, Hongli Xia, Chao Liu, Mincai Li
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 3, p 54 (2023)
Background: Neuromedin B (NMB) is a neuropeptide that plays a key role in many physiological processes and is involved in the pathology of various diseases. Increased levels of NMB have been reported in solid tumors. Therefore, we investigated the pr
Externí odkaz:
https://doaj.org/article/74e654e685e5476994891b4ca1556705
Autor:
Jingyuan Li, Li Gong, Shaozhuang Liu, Yujie Zhang, Chunmei Zhang, Mi Tian, Huixia Lu, Peili Bu, Jianmin Yang, Changhan Ouyang, Xiuxin Jiang, Jiliang Wu, Yun Zhang, Qing Min, Cheng Zhang, Wencheng Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Human antigen R (HuR) is a RNA-binding protein. Here the authors investigate its role in adipose tissue and find that it protects mice from diet-induced obesity, prevents adipocyte hypertrophy, and promotes lipolysis, which may at least in part be du
Externí odkaz:
https://doaj.org/article/ffdb9416baef42e0a24754e394971a46
Autor:
Tianran Zhang, Hongxuan Li, Changhan Ouyang, Guangqing Cao, Jiangang Gao, Jiliang Wu, Jianmin Yang, Nengwang Yu, Qing Min, Cheng Zhang, Wencheng Zhang
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101828- (2021)
Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays pivotal roles in cellular processes such as apoptosis, metabolism, and cell cycle regulation.
Externí odkaz:
https://doaj.org/article/3566b78b633e43158d6200e4b5c76dab