Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Changgong Wu"'
Autor:
Narayani Nagarajan, Shin-ichi Oka, Jihoon Nah, Changgong Wu, Peiyong Zhai, Risa Mukai, Xiaoyong Xu, Sanchita Kashyap, Chun-Yang Huang, Eun-Ah Sung, Wataru Mizushima, Allen Sam Titus, Koichiro Takayama, Youssef Mourad, Jamie Francisco, Tong Liu, Tong Chen, Hong Li, Junichi Sadoshima
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Modification of cysteine residues by oxidative and nitrosative stress affects structure and function of proteins, thereby contributing to the pathogenesis of cardiovascular disease. Although the major function of thioredoxin 1 (Trx1) is to reduce dis
Externí odkaz:
https://doaj.org/article/48ab0d010c1a459fb404bff55414eefd
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102425- (2022)
Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential for cardiovascular homeostasis but is disrupted by oxidative stress, which causes GC1 desensitization to
Externí odkaz:
https://doaj.org/article/8aff11be899542e6ac33a6e0651398b6
Autor:
Fadia Nicolas, Changgong Wu, Salwa Bukhari, Sonia M. de Toledo, Hong Li, Masayuki Shibata, Edouard I. Azzam
Publikováno v:
Proteomes, Vol 3, Iss 2, Pp 56-73 (2015)
The covalent addition of nitric oxide (NO•) onto cysteine thiols, or S-nitrosylation, modulates the activity of key signaling proteins. The dysregulation of normal S-nitrosylation contributes to degenerative conditions and to cancer. To gain insigh
Externí odkaz:
https://doaj.org/article/2a07c1a1fe7048cf8c094265a50a89af
Autor:
Shinichi Oka, Tong Liu, Changgong Wu, Xiaoyong Xu, Narayani Nagarajan, Chun-yang Huang, Junichi Sadoshima, Risa Mukai, Gihoon Nah, Peiyong Zhai, Hong Li, Wataru Mizushima
Publikováno v:
Circulation Research. 127
Thioredoxin 1 (Trx1) is an oxidoreductase that reduces proteins with disulfide bonds. Trx1 also functions as a transnitrosylase, but this occurs only when Trx1 is oxidized at Cys32 and Cys35. In cultured cardiomyocytes (CMs), glucose deprivation (GD)
Autor:
Vladyslav Kholodovych, Maryam Alapa, Can Huang, Changgong Wu, Junichi Sadoshima, Narayani Nagarajan, Annie Beuve, Hong Li, Ping Shu
Publikováno v:
Journal of Biological Chemistry. 292:14362-14370
Nitric oxide (NO) modulates many physiological events through production of cGMP from its receptor, the NO-sensitive guanylyl cyclase (GC1). NO also appears to function in a cGMP-independent manner, via S-nitrosation (SNO), a redox-based modification
Autor:
Lee Zourelias, Angela Sanguino, Changgong Wu, Kelly J. Shields, Ramaz Geguchadze, Zhimin Wang, Michael J Passineau, Kristin B. Highland, Raymond L. Benza
Publikováno v:
Human Gene Therapy. 28:681-689
Pulmonary arterial hypertension (PAH) is a progressive disease that culminates in right heart failure and death. Prostacyclin (PGI2) and its derivatives are effective treatments for PAH when administered as continuous parenteral infusions. This treat
Autor:
Michael J. Passineau, Raymond L. Benza, Kelly J. Shields, Amresh Raina, Srinivas Murali, Changgong Wu, Gretchen Williams
Publikováno v:
Pulmonary Circulation. 6:551-556
We have previously reported that pulmonary artery endothelial cells (PAECs) can be harvested from the tips of discarded Swan-Ganz catheters after right heart catheterization (RHC). In this study, we tested the hypothesis that the existence of an anti
Autor:
Kelly J. Shields, Erin M. Faight, Raymond L. Benza, Kostas Verdelis, Lee Zourelias, Michael J. Passineau, Changgong Wu, Rong Chong
Publikováno v:
Pulmonary Circulation. 6:586-596
Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling. The obesity epidemic has produced great interest in the relationship between small visceral adipose tissue depots producing localized inflammato
Autor:
Laura T. Beringer, Devora Cohen-Karni, Michael J. Passineau, Shaohua Li, Ethan Kallick, Howard Edington, Saadyah Averick, Changgong Wu
Publikováno v:
Polymer. 99:7-12
The modification of proteins with reactive handles has facilitated the use of these biomolecules in diverse fields including drug delivery, diagnostics, environmental remediation, and cell culture matrices. Recently, a new “click” type reaction,
Autor:
Tong Liu, Ahmet Tarik Baykal, Stacey Pan, Hong Li, Mohit Jain, Tetsuro Ago, Changgong Wu, Junichi Sadoshima, Narayani Nagarajan, Lin Yan, Huacheng Dai, Chuanlong Cui
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1854:1816-1822
Thioredoxin 1 (Trx1) is a antioxidant protein that regulates protein disulfide bond reduction, transnitrosylation, denitrosylation and other redox post-translational modifications. In order to better understand how Trx1 modulates downstream protectiv