Výsledky vyhledávání - "Changgang Lou"

Synthetic phospholipids as specific substrates for plasma endothelial lipase

Autor: Julien Papillon, Mark A. Gilchrist, Meihui Pan, Alok K. Singh, James Thompson, Margaret E. Brousseau, Changgang Lou, Todd Stawicki

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:3514-3517

We designed and prepared synthetic phospholipids that generate lyso-phosphatidylcholine products with a unique mass for convenient detection by LC-MS in complex biological matrices. We demonstrated that compound 4, formulated either as a Triton X-100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988e5ba2b7566e5ca800d194f21b3142
https://doi.org/10.1016/j.bmcl.2016.06.032

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Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects

Autor: Dean F. Rigel, Kerry S. Russell, Lu Gan, Julien Papillon, Chii-Whei Hu, Changgang Lou, Alok K. Singh, Daniel LaSala, Wei Chen, Gary Michael Ksander, Fumin Fu, Catherine Watson, Jennifer Leung-Chu, Arco Y. Jeng, Christopher M. Adams, Guiqing Liang, John A. Vest, Michael E. Beil

Publikováno v: Journal of Medicinal Chemistry. 58:9382-9394

Human clinical studies conducted with LCI699 established aldosterone synthase (CYP11B2) inhibition as a promising novel mechanism to lower arterial blood pressure. However, LCI699's low CYP11B1/CYP11B2 selectivity resulted in blunting of adrenocortic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e6c50d8e5e31a37972d238e9fe1c8c
https://doi.org/10.1021/acs.jmedchem.5b01545

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Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

Publikováno v: Journal of medicinal chemistry. 58(11)

CYP11B2, the aldosterone synthase, and CYP11B1, the cortisol synthase, are two highly homologous enzymes implicated in a range of cardiovascular and metabolic diseases. We have previously reported the discovery of LCI699, a dual CYP11B2 and CYP11B1 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae31b3435b92f18b555f524e3460454
https://pubmed.ncbi.nlm.nih.gov/25953419

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Determination of puerarin and daidzein in Puerariae radix and its medicinal preparations by micellar electrokinetic capillary chromatography with electrochemical detection

Autor: Yuzhi Fang, Qingcui Chu, Jiannong Ye, Xin Zhang, Yuhua Cao, Changgang Lou

Publikováno v: Analytica Chimica Acta. 452:123-128

The use of micellar electrokinetic capillary chromatography (MECC) with electrochemical detection is described for the determination of puerarin and daidzein in Puerariae radix and its medicinal preparations. Operated in a wall-jet configuration, a 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26f916d0aa2417d4af548840ad173e94
https://doi.org/10.1016/s0003-2670(01)01433-7

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Effective Killing of Leukemia Cells by the Natural Product OSW-1 through Disruption of Cellular Calcium Homeostasis*

Autor: Yan Zhou, Naima Hammoudi, Kausar Begam Riaz Ahmed, Celia Garcia-Prieto, Zhao Chen, Yan Mei, Ying Kang, Changgang Lou, Zhendong Jin, Peng Huang

3β,16β,17α-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-2-O-acetyl-α-L-arabinopyranoside (OSW-1) is a natural product with potent antitumor activity against various types of cancer cells, but the exact mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9083a266c4a118cac4dd0d4b1996aa6b
https://europepmc.org/articles/PMC3561545/

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OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action

Autor: Yan Zhou, Zeev Estrov, Zhendong Jin, Celia Garcia-Prieto, Dennis A. Carney, Helene Pelicano, Ying Kang, Seiji Kondo, Peng Huang, Rui-Hua Xu, Wensheng Yu, Jinsong Liu, Michael J. Keating, David Harris, Changgang Lou

Publikováno v: Journal of the National Cancer Institute. 97(23)

The naturally occurring compound 3beta,16beta,17alpha-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1-->3)-(2-O-acetyl-alpha-L-arabinopyranoside) (OSW-1) is found in the bulbs of Ornithogalum saudersiae and is highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f148ea2f47aeb2c0368109c191a8a19
https://pubmed.ncbi.nlm.nih.gov/16333034

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Determination of active ingredients of Rhododendron dauricum L. by capillary electrophoresis with electrochemical detection

Autor: Jiannong Ye, Changgang Lou, Yuhua Cao, Yuzhi Fang

Publikováno v: Journal of chromatography. A. 943(1)

High-performance capillary electrophoresis with electrochemical detection was employed to analyse active ingredients of Rhododendron dauricum L., an important crude herb frequently used in Chinese medicines. Farrerol, quercetin, syringic acid, vanill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5574dcf299c3ab4b37b2b435851d78d0
https://pubmed.ncbi.nlm.nih.gov/11820277

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