Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Changfu, Yao"'
Autor:
Andrew K. Beppu, Juanjuan Zhao, Changfu Yao, Gianni Carraro, Edo Israely, Anna Lucia Coelho, Katherine Drake, Cory M. Hogaboam, William C. Parks, Jay K. Kolls, Barry R. Stripp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Epithelial plasticity has been suggested in lungs of mice following genetic depletion of stem cells but is of unknown physiological relevance. Viral infection and chronic lung disease share similar pathological features of stem cell loss in
Externí odkaz:
https://doaj.org/article/9706ebfced8e45afb13ec6066322b3aa
Autor:
Jiurong Liang, Guanling Huang, Xue Liu, Ningshan Liu, Forough Taghavifar, Kristy Dai, Changfu Yao, Nan Deng, Yizhou Wang, Peter Chen, Cory Hogaboam, Barry R Stripp, William C Parks, Paul W Noble, Dianhua Jiang
Publikováno v:
eLife, Vol 12 (2023)
Aging is a critical risk factor in idiopathic pulmonary fibrosis (IPF). Dysfunction and loss of type 2 alveolar epithelial cells (AEC2s) with failed regeneration is a seminal causal event in the pathogenesis of IPF, although the precise mechanisms fo
Externí odkaz:
https://doaj.org/article/dc36e141f9de42bfa03fa5b279b8212e
Autor:
Konstantinos-Dionysios Alysandratos, Carolina Garcia-de-Alba, Changfu Yao, Patrizia Pessina, Jessie Huang, Carlos Villacorta-Martin, Olivia T. Hix, Kasey Minakin, Claire L. Burgess, Pushpinder Bawa, Aditi Murthy, Bindu Konda, Michael F. Beers, Barry R. Stripp, Carla F. Kim, Darrell N. Kotton
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of human in vitro models. However, AEC2-like cells in culture have yet
Externí odkaz:
https://doaj.org/article/f25a0ef19189460ebd6f7a2ad18d270c
Autor:
Yapei Huang, Juliana E. Shin, Alexander M. Xu, Changfu Yao, Sandy Joung, Min Wu, Ruan Zhang, Bongha Shin, Joslyn Foley, Simeon B. Mahov, Matthew E. Modes, Joseph E. Ebinger, Matthew Driver, Jonathan G. Braun, Caroline A. Jefferies, Tanyalak Parimon, Chelsea Hayes, Kimia Sobhani, Akil Merchant, Sina A. Gharib, Stanley C. Jordan, Susan Cheng, Helen S. Goodridge, Peter Chen
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105209- (2022)
Summary: SARS-CoV-2 vaccines have unquestionably blunted the overall impact of the COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals in a relatively healthy
Externí odkaz:
https://doaj.org/article/01a952f077a642f7a2bb1d61db9271c4
Autor:
Jiurong Liang, Guanling Huang, Xue Liu, Forough Taghavifar, Ningshan Liu, Yizhou Wang, Nan Deng, Changfu Yao, Ting Xie, Vrishika Kulur, Kristy Dai, Ankita Burman, Simon C. Rowan, S. Samuel Weigt, John Belperio, Barry Stripp, William C. Parks, Dianhua Jiang, Paul W. Noble
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Type 2 alveolar epithelial cells (AEC2s) function as progenitor cells in the lung. We have shown previously that failure of AEC2 regeneration results in progressive lung fibrosis in mice and is a cardinal feature of idiopathic pulmonary fibrosis (IPF
Externí odkaz:
https://doaj.org/article/f7539cbaaa2b4928beaa1bce4118eb7f
Autor:
Tingting Yuan, Thomas Volckaert, Elizabeth F. Redente, Seantel Hopkins, Kylie Klinkhammer, Roxana Wasnick, Cho-Ming Chao, Jie Yuan, Jin-San Zhang, Changfu Yao, Susan Majka, Barry R. Stripp, Andreas Günther, David W.H. Riches, Saverio Bellusci, Victor J. Thannickal, Stijn P. De Langhe
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 1041-1055 (2019)
Summary: Idiopathic pulmonary fibrosis is a common form of interstitial lung disease resulting in alveolar remodeling and progressive loss of pulmonary function because of chronic alveolar injury and failure to regenerate the respiratory epithelium.
Externí odkaz:
https://doaj.org/article/fcba214ffea4484dac67b28149cb14a9
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100582- (2021)
Summary: Single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) allows in-depth assessment of transcriptional changes in immune cells of patients with COVID-19. However, collecting, processing, and analyzing samples from
Externí odkaz:
https://doaj.org/article/042407cb2b384e239b51852e7073c1e9
Autor:
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102551- (2021)
Summary: Pulmonary mesenchymal cells are critical players in both the mouse and human during lung development and disease states. They are increasingly recognized as highly heterogeneous, but there is no consensus on subpopulations or discriminative
Externí odkaz:
https://doaj.org/article/61fae4523109433c93b49fa80896a3e0
Autor:
Apoorva Mulay, Bindu Konda, Gustavo Garcia, Jr., Changfu Yao, Stephen Beil, Jaquelyn M. Villalba, Colin Koziol, Chandani Sen, Arunima Purkayastha, Jay. K. Kolls, Derek A. Pociask, Patrizia Pessina, Julio Sainz de Aja, Carolina Garcia-de-Alba, Carla F. Kim, Brigitte Gomperts, Vaithilingaraja Arumugaswami, Barry R. Stripp
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109055- (2021)
Summary: Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although infection initiates in the proximal airways, severe and sometimes fatal symptoms
Externí odkaz:
https://doaj.org/article/c6b335eff48e42068ebd55ba5f9b3751
Autor:
Changfu Yao, Stephanie A. Bora, Tanyalak Parimon, Tanzira Zaman, Oren A. Friedman, Joseph A. Palatinus, Nirmala S. Surapaneni, Yuri P. Matusov, Giuliana Cerro Chiang, Alexander G. Kassar, Nayan Patel, Chelsi E.R. Green, Adam W. Aziz, Harshpreet Suri, Jo Suda, Andres A. Lopez, Gislâine A. Martins, Barry R. Stripp, Sina A. Gharib, Helen S. Goodridge, Peter Chen
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108943- (2021)
Externí odkaz:
https://doaj.org/article/d1095ed61182462a817f5dee782da1c7