Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Changde Zhang"'
Autor:
Borui Kang, Madhusoodanan Mottamal, Qiu Zhong, Melyssa Bratton, Changde Zhang, Shanchun Guo, Ahamed Hossain, Peng Ma, Qiang Zhang, Guangdi Wang, Florastina Payton-Stewart
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 735 (2023)
Niclosamide effectively downregulates androgen receptor variants (AR-Vs) for treating enzalutamide and abiraterone-resistant prostate cancer. However, the poor pharmaceutical properties of niclosamide due to its solubility and metabolic instability h
Externí odkaz:
https://doaj.org/article/a6130f7ca6f84e439096e3bc86c740c5
Autor:
Jiawang Liu, Nirmal Rajasekaran, Ahamed Hossain, Changde Zhang, Shanchun Guo, Borui Kang, Hunsoon Jung, Hongjoong Kim, Guangdi Wang
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 719 (2021)
Fulvestrant-3-boronic acid (ZB716), an oral selective estrogen receptor degrader (SERD) under clinical development, has been investigated in ADME studies to characterize its absorption, metabolism, and pharmacokinetics. ZB716 was found to have high p
Externí odkaz:
https://doaj.org/article/5d85474ec58743c081630b0877709f00
Autor:
Tiffany N Eady, Ludmila Belayev, Larissa Khoutorova, Kristal D Atkins, Changde Zhang, Nicolas G Bazan
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46151 (2012)
Docosahexaenoic acid, a major omega-3 essential fatty acid family member, improves behavioral deficit and reduces infarct volume and edema after experimental focal cerebral ischemia. We hypothesize that DHA elicits neuroprotection by inducing AKT/p70
Externí odkaz:
https://doaj.org/article/526678fbbe39441d9bb91dbb06fb85ec
Autor:
Hun Soon Jung, Hongjoong Kim, Shanchun Guo, Nirmal Rajasekaran, Jiawang Liu, Changde Zhang, Ahamed Hossain, Borui Kang, Guangdi Wang
Publikováno v:
Pharmaceuticals, Vol 14, Iss 719, p 719 (2021)
Pharmaceuticals
Volume 14
Issue 8
Pharmaceuticals
Volume 14
Issue 8
Fulvestrant-3-boronic acid (ZB716), an oral selective estrogen receptor degrader (SERD) under clinical development, has been investigated in ADME studies to characterize its absorption, metabolism, and pharmacokinetics. ZB716 was found to have high p
Publikováno v:
Journal of the Endocrine Society
Methylparaben, ethylparaben, and propylparaben are widely used as preservatives in food, cosmetics, and pharmaceutical products. Parabens are also known to bind the estrogen receptor and induce weak estrogen activity in laboratory bioassays. Many OTC
Publikováno v:
Journal of the Endocrine Society
Methylparaben, ethylparaben, and propylparaben are widely used as preservatives in food products, cosmetics, and pharmaceuticals. Parabens have been shown to be weak estrogens and this laboratory has described that extracts of some over the counter (
Autor:
Shanchun Guo, Guangdi Wang, Lan Luo, Ling He, Shilong Zheng, Qiang Zhang, Qiu Zhong, Changde Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
PI-103 (7) is a potent dual phosphatidylinositol 3-kinase (PI3K)/mTOR inhibitor, but its rapid in vivo metabolism hinders its further clinical development. To improve the bioavailability of PI-103, we designed and synthesized a PI-103 bioisostere, PI
Autor:
Aaron Gonzalez, Ryan Fong, Guanglin Chen, Pravien Rajaram, Qiang Zhang, Shanchun Guo, Maizie Lee, Guangdi Wang, Xiang Li, Changde Zhang, Shilong Zheng, Qiao-Hong Chen
Publikováno v:
European Journal of Medicinal Chemistry. 157:978-993
Thirty-eight 3-O-substituted-3′,4′-dimethoxyflavonols and twenty-five 3-O-substituted-3′,4′,7-trimethoxyflavonols have been synthesized for systematic investigation on the structure-activity relationships of 3-O-substituted-3′,4′-dimethox
Autor:
Changde Zhang, Jiawang Liu, Guangdi Wang, Ahamed Hossain, Shanchun Guo, Madhusoodanan Mottamal
Publikováno v:
Breast Cancer Res Treat
PURPOSE: Selective estrogen receptor degrader (SERD) has proven clinically effective in treating advanced or metastatic breast cancer since the approval of fulvestrant by FDA in 2002. Recent expansion of indications as a first line monotherapy and as
Autor:
Shanchun Guo, Madhusoodanan Mottamal, Lin Yang, Qiu Zhong, René Houtman, Changde Zhang, Melyssa R. Bratton, Margarite D. Matossian, Yong Wu, Guangdi Wang, Matthew E. Burow, Shilong Zheng, Lucio Miele, Matthew J. Ellis, Jiawang Liu, Thomas E. Wiese, Peng Ma
Publikováno v:
Oncotarget
// Shanchun Guo 1, 2 , Changde Zhang 1, 2 , Melyssa Bratton 2, 3 , Madhusoodanan Mottamal 1, 2 , Jiawang Liu 1, 2 , Peng Ma 2, 3 , Shilong Zheng 1, 2 , Qiu Zhong 1, 2 , Lin Yang 4 , Thomas E. Wiese 2, 3 , Yong Wu 5 , Matthew J. Ellis 6 , Margarite Ma