Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Changcheng Jing"'
Autor:
Changcheng Jing, Shahida Mallah, Ella Kriemen, Steven H. Bennett, Valerio Fasano, Alastair J. J. Lennox, Ingeborg Hers, Varinder K. Aggarwal
Publikováno v:
ACS Central Science, Vol 6, Iss 6, Pp 995-1000 (2020)
Externí odkaz:
https://doaj.org/article/2b3908695373437cbc6460d721595eea
Publikováno v:
Journal of the American Chemical Society
Unique examples of aza-Heck-based C(sp3)-H functionalization cascades are described. Under Pd(0)-catalyzed conditions, the aza-Heck-type cyclization of N-(pentafluorobenzoyloxy)carbamates generates alkyl-Pd(II) intermediates that effect C(sp3)-H pall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1dac74afd885895abf9beb667aee63
https://doi.org/10.1021/jacs.2c08304
https://doi.org/10.1021/jacs.2c08304
Publikováno v:
Journal of the American Chemical Society. 144(37)
Unique examples of aza-Heck-based C(sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8acb3dcbd72a89396b398150cf81d2a0
https://pubmed.ncbi.nlm.nih.gov/36083505
https://pubmed.ncbi.nlm.nih.gov/36083505
Autor:
Changcheng Jing, Varinder K. Aggarwal
Publikováno v:
Jing, C & Aggarwal, V K 2020, ' Total Synthesis of Thromboxane B2 via a Key Bicyclic Enal Intermediate ', Organic Letters, vol. 22, no. 16, pp. 6505-6509 . https://doi.org/10.1021/acs.orglett.0c02299
A 12-step asymmetric synthesis of thromboxane B2 (TxB2) from 2,5-dimethoxytetrahydrofuran is described. The synthesis employs our organocatalytic aldol reaction of succinaldehyde to give a key bicyclic enal intermediate. From here, the synthetic stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18441f626d213dadaeb9a15d8795b9b2
https://doi.org/10.1021/acs.orglett.0c02299
https://doi.org/10.1021/acs.orglett.0c02299
Autor:
Varinder K. Aggarwal, Shahida Mallah, Valerio Fasano, Ella Kriemen, Ingeborg Hers, Steven H. Bennett, Changcheng Jing, Alastair J. J. Lennox
Publikováno v:
ACS Central Science, Vol 6, Iss 6, Pp 995-1000 (2020)
Jing, C, Mallah, S, Kriemen, E, Bennett, S H, Fasano, V, Lennox, A J J, Hers, I & Aggarwal, V K 2020, ' Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2 ', ACS Central Science, vol. 6, no. 6, pp. 995–1000 . https://doi.org/10.1021/acscentsci.0c00310
Jing, C, Mallah, S, Kriemen, E, Bennett, S H, Fasano, V, Lennox, A J J, Hers, I & Aggarwal, V K 2020, ' Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2 ', ACS Central Science, vol. 6, no. 6, pp. 995–1000 . https://doi.org/10.1021/acscentsci.0c00310
Platelet activation results in the generation of thromboxane A2 (TxA2), which promotes thrombus formation by further amplifying platelet function, as well as causing vasoconstriction. Due to its role in thrombus formation and cardiovascular disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9a9d1fa6c95aaea7a62181f963fdf6
https://doaj.org/article/2b3908695373437cbc6460d721595eea
https://doaj.org/article/2b3908695373437cbc6460d721595eea
Publikováno v:
CHEMICAL RECORD
Dearomatization reactions allow the direct synthesis of structurally complex sp3 -rich molecules from readily available "flat" precursors. Established dearomatization processes commonly involve the formation of new C-C bonds, whereas methods that ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f47d349216bd7973969f194feb3b89b
https://pubmed.ncbi.nlm.nih.gov/34240537
https://pubmed.ncbi.nlm.nih.gov/34240537
Autor:
Changcheng Jing, Xinxin Lv, Taoda Shi, Xinfang Xu, Yu Qian, Wenhao Hu, Gopi Krishna Reddy Alavala
Publikováno v:
Organic & Biomolecular Chemistry. 17:9792-9798
Norstatine derivatives are of important value in pharmaceutical science. However, their catalytic asymmetric synthesis is rare. We developed a sustainable method via chiral phosphoric acid (CPA)-[Rh(OAc)2]2 co-catalyzed multi-component reactions (MCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9064e3bc2f7b6d35d5b99ca7e3a2bf
https://doi.org/10.1039/c9ob02149c
https://doi.org/10.1039/c9ob02149c
Publikováno v:
Yu, S, Jing, C, Noble, A & Aggarwal, V K 2020, ' Iridium-Catalyzed Enantioselective Synthesis of α-Chiral Bicyclo[1.1.1]pentanes by 1,3-Difunctionalization of [1.1.1]Propellane ', Organic Letters, vol. 22, no. 14, pp. 5650-5655 . https://doi.org/10.1021/acs.orglett.0c02017
Organic Letters
Organic Letters
Bicyclo[1.1.1]pentanes (BCPs) have found application as bioisosteres of aromatic rings in drug development. However, catalytic construction of this motif with adjacent stereocenters with high enantioselectivity from readily available starting materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a8e758572daf37bee93ca2b13a9fdb
https://pubmed.ncbi.nlm.nih.gov/32638587
https://pubmed.ncbi.nlm.nih.gov/32638587
1,3‐Difunctionalizations of [1.1.1]Propellane via 1,2‐Metallate Rearrangements of Boronate Complexes
Publikováno v:
Angewandte Chemie International Edition
Yu, S, Jing, C, Noble, A & Aggarwal, V K 2020, ' 1,3-Difunctionalizations of [1.1.1]Propellane via 1,2-Metallate Rearrangements of Boronate Complexes ', Angewandte Chemie-International Edition, vol. 59, no. 10, pp. 3917-3921 . https://doi.org/10.1002/anie.201914875
Yu, S, Jing, C, Noble, A & Aggarwal, V K 2020, ' 1,3-Difunctionalizations of [1.1.1]Propellane via 1,2-Metallate Rearrangements of Boronate Complexes ', Angewandte Chemie-International Edition, vol. 59, no. 10, pp. 3917-3921 . https://doi.org/10.1002/anie.201914875
1,3-Disubstituted bicyclo[1.1.1]pentanes (BCPs) are valuable bioisosteres of para-substituted aromatic rings. The most direct route to these structures is via multicomponent ring-opening reactions of [1.1.1]propellane. However, challenges associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d30ee2bc5df1d1be43591d725531fd3
Publikováno v:
Organometallics. 35:3413-3420
Catalyst effectiveness for metal carbene formation and reactions has been surveyed using N-(tert-butyl)-3-[(tert-butyldimethylsilyl)oxy]-2-diazo-N-(4-chlorobenzyl)but-3-enamide in the formation of the products from both intramolecular C–H insertion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47f9266aeb6566fe5a03b2607ad61fb4
https://doi.org/10.1021/acs.organomet.6b00648
https://doi.org/10.1021/acs.organomet.6b00648