Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Changalvala V. S. Ramamurty"'
Publikováno v:
The Journal of Organic Chemistry. 76:2245-2247
The 3,5-di-O-benzoyl n-pentenyl orthoesters of the four pentofuranoses have been prepared. The first key intermediate in each case is the methyl pentofuranoside(s), and a user-friendly procedure for the preparation of each, based on the Callam-Lowary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b1f6337b14466d885a6517458b7ba2
https://doi.org/10.1021/jo1021376
https://doi.org/10.1021/jo1021376
Autor:
Jerry Muhammad, Babita Ganguly, Claire Bourdin, Stanley D. Chamberlain, Jeff T. Hutchins, Joseph M. Patti, C. Robin Walters, Andrea Brancale, Alexander A. Kolykhalov, Changalvala V. S. Ramamurty, Christopher McGuigan, Jin Wang, Aleksandr Obikhod, K. Dawn Bryant, Srinivas K. Battina, Elena Gorovits, Blair Bleiman, John Vernachio, Geoffrey W. Henson, Damound Hunley, C.Srivinas Rao
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
7-Deazapurines are known to possess broad antiviral activity, however the 2′-C-methylguanosine analogue displays poor cell permeation and limited phosphorylation, thus is not an efficient inhibitor of hepatitis C virus (HCV) replication. We previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e69113496b9dfc3ef7a22f3fb6db0bc
https://pubmed.ncbi.nlm.nih.gov/23453067
https://pubmed.ncbi.nlm.nih.gov/23453067
Autor:
Maria A. Arrica, Jeff T. Hutchins, Jerry Muhammad, C. Robin Walters, Blair Bleiman, John Vernachio, Geoffrey W. Henson, Karolina Madela, Claire Bourdin, K. Dawn Bryant, Damound Hunley, Aleksandr Obikhod, Alexander A. Kolykhalov, Elena Gorovits, Joseph M. Patti, Jin Wang, Emma Barrett, Srinivas K. Battina, Christopher McGuigan, Mohamed Aljarah, Stanley D. Chamberlain, Sarah Jones, Changalvala V. S. Ramamurty, Babita Ganguly
Publikováno v:
Journal of medicinal chemistry. 54(24)
We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2′-C-methyl guanosines, with significant variation in the diamidate structure. Both symmetrical and asy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716ba7adc05880ff240ed55f2a1ffb06
https://pubmed.ncbi.nlm.nih.gov/22039920
https://pubmed.ncbi.nlm.nih.gov/22039920
Autor:
Changalvala V. S. Ramamurty, Stanley D. Chamberlain, Christopher McGuigan, Alexander A. Kolykhalov, C. Srinivas Rao, Andrea Hall, Mohamed Aljarah, Srinivas K. Battina, John Vernachio, Jeff T. Hutchins, Geoffrey W. Henson, Arnaud Gilles, Karolina Madela
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
We have previously reported the power of combining a 5′-phosphoramidate ProTide, phosphate pro-drug, motif with a 6-methoxy purine pro-drug entity to generate highly potent anti-HCV agents, leading to agents in clinical trial. We herein extend this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c22d162f7fcfba7bb6b4c4ced2f78c6
https://pubmed.ncbi.nlm.nih.gov/21856153
https://pubmed.ncbi.nlm.nih.gov/21856153
Autor:
Bert Fraser-Reid, K. N. Jayaprakash, Jun Lu, Siddhartha Ray Chaudhuri, Changalvala V. S. Ramamurty
Publikováno v:
The Journal of organic chemistry. 73(24)
Lipomannan (LM) is one of the domains of lipoarabinomannan (LAM) glycolipids, the latter being one of several cell surface organic molecules that fortify mycobacterial species against external attack. Some members of mycobacterial families are pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b04f44c63dd4d8407657b7292786ae8
https://pubmed.ncbi.nlm.nih.gov/18989931
https://pubmed.ncbi.nlm.nih.gov/18989931
Autor:
Bert Fraser-Reid, Ana M. Gómez, Parimala Ganney, J. Cristobal Lopez, Changalvala V. S. Ramamurty
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Strategically derivatized NPOE glycosyl donors, are able to efficiently glycosylate silylated nucleobases under mild conditions, even as low as -78°C if necessary. Ensuring trans-1,2 glycosylation, thus permitting, unlike classical procedures, a Rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c1d210bd7d4f864465e9adfcb57ea1
https://doi.org/10.1039/c3cc41036f
https://doi.org/10.1039/c3cc41036f