Zobrazeno 1 - 10
of 203
pro vyhledávání: '"ChangYu Zheng"'
Autor:
Vaishali N. Patel, Marit H. Aure, Sophie H. Choi, James R. Ball, Ethan D. Lane, Zhangjie Wang, Yongmei Xu, Changyu Zheng, Xibao Liu, Daniel Martin, Jillian Y. Pailin, Michaela Prochazkova, Ashok B. Kulkarni, Toin H. van Kuppevelt, Indu S. Ambudkar, Jian Liu, Matthew P. Hoffman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG) development, is determined by the immense structural diversity of sulfated HS domains. 3-O-sulfotransferases generate highly 3-O-sulfated HS domains
Externí odkaz:
https://doaj.org/article/1d729c7a230d48a69e9967ba3a35489e
Autor:
Vaishali N. Patel, Marit H. Aure, Sophie H. Choi, James R. Ball, Ethan D. Lane, Zhangjie Wang, Yongmei Xu, Changyu Zheng, Xibao Liu, Daniel Martin, Jillian Y. Pailin, Michaela Prochazkova, Ashok B. Kulkarni, Toin H. van Kuppevelt, Indu S. Ambudkar, Jian Liu, Matthew P. Hoffman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/39016b373ef84ced8aa59dfb3ebcf038
Autor:
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Sjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the de
Externí odkaz:
https://doaj.org/article/44e1f0ed2ac2493291931e871aadc7d4
Autor:
Hiroyuki Nakamura, Tsutomu Tanaka, Youngmi Ji, Changyu Zheng, Sandra A Afione, Blake M Warner, Fabiola Reis Oliveira, Ana Carolina F Motta, Eduardo M Rocha, Masayuki Noguchi, Tatsuya Atsumi, John A Chiorini
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0282227 (2023)
Hydroxychloroquine (HCQ) is a lysosomotropic agent that is commonly used for treating Sjögren's disease (SjD). However, its efficacy is controversial because of the divergent response to the drug among patients. In a subgroup of SjD patients, lysoso
Externí odkaz:
https://doaj.org/article/acc41cde337d44419ebc591577fb4021
Autor:
Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke, Frank I. Lin
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Background PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [18F]DC
Externí odkaz:
https://doaj.org/article/cca22949d8694e11bdc75a8355c78adb
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A severe consequence of radiation therapy in patients with head and neck cancer is persistent salivary gland hypofunction which causes xerostomia and oral infections. We previously showed that irradiation (IR) of salivary glands in mice trig
Externí odkaz:
https://doaj.org/article/db207e2ba12f48e08b162307148ad41f
Autor:
Giovanni Di Pasquale, Paola Perez Riveros, Muhibullah Tora, Tayyab Sheikh, Aran Son, Leyla Teos, Brigitte Grewe, William D. Swaim, Sandra Afione, Changyu Zheng, Shyh-Ing Jang, Akiko Shitara, Ilias Alevizos, Roberto Weigert, John A. Chiorini
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 459-466 (2020)
The loss of salivary gland function caused by radiation therapy of the head and neck or autoimmune disease such as Sjögren’s syndrome is a serious condition that affects a patient’s quality of life. Due to the combined exocrine and endocrine fun
Externí odkaz:
https://doaj.org/article/7be847276d9a4acbaec511e36b5c72eb
Autor:
Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Paola Perez, Youngmi Ji, Benjamin N. French, Thomas J.F. Pranzatelli, Drew G. Michael, Hongen Yin, Susan S. Chow, Maryam Khalaj, Sandra A. Afione, Changyu Zheng, Fabiola Reis Oliveira, Ana Carolina F. Motta, Alfredo Ribeiro-Silva, Eduardo M. Rocha, Cuong Q. Nguyen, Masayuki Noguchi, Tatsuya Atsumi, Blake M. Warner, John A. Chiorini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
BMP6 is a central cytokine in the induction of Sjögren’s syndrome–associated (SS-associated) secretory hypofunction. However, the upstream initiation leading to the production of this cytokine in SS is unknown. In this study, RNA ISH on salivary
Externí odkaz:
https://doaj.org/article/13dceb0a01ca49398b123ad81af78fba
Autor:
Isabelle M.A. Lombaert, Vaishali N. Patel, Christina E. Jones, Derrick C. Villier, Ashley E. Canada, Matthew R. Moore, Elsa Berenstein, Changyu Zheng, Corinne M. Goldsmith, John A. Chorini, Daniel Martin, Lee Zourelias, Mark G. Trombetta, Paul C. Edwards, Kathleen Meyer, Dale Ando, Michael J. Passineau, Matthew P. Hoffman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 839-855 (2020)
Salivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need. We used an adeno-associated virus serotype 2 (AAV2
Externí odkaz:
https://doaj.org/article/9043b0d9998246adb36e026172057354
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 526-538 (2019)
Background: Sjögren's syndrome (SS) is one of the most common autoimmune disorders leading to exocrine gland dysfunction. Both immune-dependent processes – like Type I Interferon (IFN) signaling and immune-independent processes – such as calcium
Externí odkaz:
https://doaj.org/article/e307f39e99e94b3aab63aa8c116a8bfe