Seasonal changes in diet and chemical defense in the Climbing Mantella frog (Mantella laevigata).

Autor: Nora A Moskowitz, Alexandre B Roland, Eva K Fischer, Ndimbintsoa Ranaivorazo, Charles Vidoudez, Marianne T Aguilar, Sophia M Caldera, Jacqueline Chea, Miruna G Cristus, Jett P Crowdis, Bluyé DeMessie, Caroline R desJardins-Park, Audrey H Effenberger, Felipe Flores, Michael Giles, Emma Y He, Nike S Izmaylov, ChangWon C Lee, Nicholas A Pagel, Krystal K Phu, Leah U Rosen, Danielle A Seda, Yong Shen, Santiago Vargas, Andrew W Murray, Eden Abebe, Sunia A Trauger, David A Donoso, Miguel Vences, Lauren A O'Connell

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0207940 (2018)

Poison frogs acquire chemical defenses from the environment for protection against potential predators. These defensive chemicals are lipophilic alkaloids that are sequestered by poison frogs from dietary arthropods and stored in skin glands. Despite

Externí odkaz: https://doaj.org/article/46b30a198fb3489293183c6da339fab1

Host immunomodulatory lipids created by symbionts from dietary amino acids

Autor: Da-Jung Jung, Jérôme Le Nours, Dennis L. Kasper, Jesang Lee, ChangWon C. Lee, Hyun-Soo Kim, Seung Bum Park, Yoon Soo Hwang, Deniz Erturk-Hasdemir, Jamie Rossjohn, Ji-Sun Yoo, Heebum Song, T. Praveena, Sungwhan F. Oh, Richard S. Blumberg

Publikováno v: Nature

Small molecules derived from symbiotic microbiota critically contribute to intestinal immune maturation and regulation1. However, little is known about the molecular mechanisms that control immune development in the host–microbiota environment. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08107eb64087645ec0f9e1590f0ab439
https://doi.org/10.1038/s41586-021-04083-0

Factors Associated With Generic Drug Uptake in the United States, 2012 to 2017

Autor: Aaron S. Kesselheim, Joshua J. Gagne, ChangWon C. Lee, Benjamin N. Rome

Publikováno v: Value in Health. 24:804-811

In the United States, brand-name prescription drugs remain expensive until market exclusivity ends and lower-cost generics become available. Delayed generic drug uptake may increase spending and worsen medication adherence and patient outcomes. We as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab746a4285b2c8853b8b060e639f94b0
https://doi.org/10.1016/j.jval.2020.12.020

An Overview Of Vaccine Development, Approval, And Regulation, With Implications For COVID-19

Autor: Beatrice L. Brown, Mayookha Mitra-Majumdar, Osman Moneer, Jerry Avorn, ChangWon C. Lee, Aaron S. Kesselheim, Martin Kulldorff, Jonathan J. Darrow

Publikováno v: Health Affairs. 40:25-32

The Food and Drug Administration generally approves vaccines when their benefits outweigh their risks for their intended use. In this paper, we review current and potential approaches to this criti...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e6ddca906efe9a9ccb4de2f30aa2903
https://doi.org/10.1377/hlthaff.2020.01620

Analysis of Launch and Postapproval Cancer Drug Pricing, Clinical Benefit, and Policy Implications in the US and Europe

Autor: Thomas Rosemann, Thomas Grischott, Aaron S. Kesselheim, Paola Daniore, Thomas J Hwang, Kerstin Noëlle Vokinger, Ariadna Tibau, ChangWon C. Lee

Publikováno v: JAMA Oncology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)
JAMA Oncol

IMPORTANCE The high cost of cancer medicines is a public health challenge. Policy makers in the US and Europe are debating reforms to drug pricing that would cover both the prices of new medicines when entering the market and price increases after th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b42dec71ef605caff4f6ea03331c40
https://doi.org/10.5167/uzh-206610