Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization.

Autor: Wu YW; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Lee DY; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Lu YL; Core Facility Center, Office of Research and Development, Taipei Medical University, Taipei, Taiwan., Delila L; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Nebie O; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Barro L; International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Changou CA; Core Facility Center, Office of Research and Development, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Translational Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; The Ph.D. Program for Cancer Biology and Drug Discovery, Center for Translational Medicine, Taipei Medical University, Taipei, Taiwan., Lu LS; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.; The Ph.D. Program for Cancer Biology and Drug Discovery, Center for Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan.; Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan., Goubran H; Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Burnouf T; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.; The Ph.D. Program for Cancer Biology and Drug Discovery, Center for Translational Medicine, Taipei Medical University, Taipei, Taiwan.; International PhD Program in Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Publikováno v: Platelets [Platelets] 2023 Dec; Vol. 34 (1), pp. 2237134.

Thyroid Hormone Induces Oral Cancer Growth via the PD-L1-Dependent Signaling Pathway.

Autor: Su KW; Department of Dentistry, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan., Lin HY; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA., Chiu HC; Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei 11490, Taiwan., Shen SY; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., ChangOu CA; Core Facility, Taipei Medical University, Taipei 11031, Taiwan., Crawford DR; Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA., Yang YSH; Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan., Shih YJ; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan., Li ZL; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan., Huang HM; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan., Whang-Peng J; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan., Ho Y; School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan., Wang K; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.

Publikováno v: Cells [Cells] 2022 Sep 29; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 29.

Heteronemin and tetrac derivatives suppress non-small cell lung cancer growth via ERK1/2 inhibition.

Autor: Chung CC; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan; Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: james092778@gmail.com., Huang TY; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei, Taiwan. Electronic address: charvel0203@gmail.com., Chu HR; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei, Taiwan. Electronic address: a0918362166@tmu.edu.tw., De Luca R; Department of Sciences, University Roma Tre, Rome, Italy. Electronic address: rdeluca@bidmc.harvard.edu., Candelotti E; Department of Sciences, University Roma Tre, Rome, Italy. Electronic address: elena.candelotti@uniroma3.it., Huang CH; Division of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan. Electronic address: hchbox@cgh.org.tw., Yang YSH; Joint Biobank, Office of Human Research, Taipei Medical University, Taipei, Taiwan. Electronic address: can_0131@tmu.edu.tw., Incerpi S; Department of Sciences, University Roma Tre, Rome, Italy. Electronic address: sandra.incerpi@uniroma3.it., Pedersen JZ; Department of Biology, University of Rome Tor Vergata, Rome, Italy. Electronic address: j.z.pedersen@gmail.com., Lin CY; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: alexlin1018@gmail.com., Huang HM; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: hhm@tmu.edu.tw., Lee SY; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: seanlee@tmu.edu.tw., Li ZL; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei, Taiwan. Electronic address: lizilin0919@gmail.com., ChangOu CA; Core Facility Center, Office of Research and Development, Taipei Medical University, Taipei, Taiwan; Integrated Laboratory, Center of Translational Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: austinc99@tmu.edu.tw., Li WS; Laboratory of Chemical Biology and Medicinal Chemistry, Institute of Chemistry, Academia Sinica, Taipei, Taiwan. Electronic address: wenshan@gate.sinica.edu.tw., Davis PJ; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USA. Electronic address: pdavis.ordwayst@gmail.com., Lin HY; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Medicine, Albany Medical College, Albany, NY, USA; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: linhy@tmu.edu.tw., Whang-Peng J; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: jqwpeng@nhri.org.tw., Wang K; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei, Taiwan. Electronic address: wangk007@gmail.com.

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Mar; Vol. 161, pp. 112850. Date of Electronic Publication: 2022 Feb 10.

CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation.

Autor: Ajoy R; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan.; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Lo YC; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan.; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Ho MH; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan.; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chen YY; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan.; Department of Biomedical Engineering, National Yang Ming University, No.155, Sec.2, Taipei, Taiwan.; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Wang Y; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan., Chen YH; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Jing-Yuan C; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Changou CA; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei Medical University and Academia Sinica, Taipei, Taiwan.; The Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei Medical University, Taipei, Taiwan.; Core Facility, Taipei Medical University, Taipei, Taiwan., Hsiung YC; Core Facility, Taipei Medical University, Taipei, Taiwan., Chen HM; Core Facility, Taipei Medical University, Taipei, Taiwan.; Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chang TH; Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan., Lee CY; Research Information Session, Office of Information Technology, Taipei Medical University, Taipei, Taiwan., Chiang YH; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan.; Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan., Chang WC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hoffer B; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan.; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Department of Neurosurgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Scientist Emeritus, National Institutes of Health, Bethesda, MD, USA., Chou SY; Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan. sichou@gmail.com.; Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. sichou@gmail.com.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2021 Nov; Vol. 26 (11), pp. 6451-6468. Date of Electronic Publication: 2021 Apr 30.

Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes.

Autor: Hsu SC; Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.; Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan., Chen CL; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan., Cheng ML; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan., Chu CY; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.; CRISPR Gene Targeting Core Lab, Taipei Medical University, Taipei 110, Taiwan., Changou CA; The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.; The PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 110, Taiwan., Yu YL; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan., Yeh SD; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Urology, Taipei Medical University Hospital, Taipei 110, Taiwan., Kuo TC; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan., Kuo CC; Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan., Chuu CP; Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan., Li CF; Department of Pathology, Chi Mei Medical Center, Tainan City 73657, Taiwan.; Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan., Wang LH; Chinese Medicine Research Center and Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan., Chen HW; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA., Yen Y; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan., Ann DK; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA., Wang HJ; Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan.; Doctoral Degree Program in Translational Medicine, Tzu Chi University and Academia Sinica, Hualien 97004, Taiwan., Kung HJ; Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan.; Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.; Department of Biochemistry and Molecular Medicine, Comprehensive Cancer Center, University of California, Davis, Sacramento, CA 95817, USA.

Publikováno v: Theranostics [Theranostics] 2021 Jun 04; Vol. 11 (15), pp. 7527-7545. Date of Electronic Publication: 2021 Jun 04 (Print Publication: 2021).