Zobrazeno 1 - 10
of 217
pro vyhledávání: '"ChangHao, Bi"'
Autor:
Junxi Chi, Pengju Wang, Yidan Ma, Xingmiao Zhu, Leilei Zhu, Ming Chen, Changhao Bi, Xueli Zhang
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract From both economic and environmental perspectives, ethylene glycol, the principal constituent in the degradation of PET, emerges as an optimal feedstock for microbial cell factories. Traditional methods for constructing Escherichia coli chas
Externí odkaz:
https://doaj.org/article/bd842497b34248aebc8d368e18b44404
Autor:
Yidong Wu, Xiaoling Wan, Dongdong Zhao, Xuxu Chen, Yujie Wang, Xinxin Tang, Ju Li, Siwei Li, Xiaodong Sun, Changhao Bi, Xueli Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Base editing technology is an ideal solution for treating pathogenic single-nucleotide variations (SNVs). No gene editing therapy has yet been approved for eye diseases, such as retinitis pigmentosa (RP). Here, we show, in the rd10 mouse mod
Externí odkaz:
https://doaj.org/article/ffee35ca7a3f42188249064d40c5613a
Autor:
Chao Yang, Zhenzhen Ma, Keshan Wang, Xingxiao Dong, Meiyu Huang, Yaqiu Li, Xiagu Zhu, Ju Li, Zhihui Cheng, Changhao Bi, Xueli Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract C-to-G base editors have been successfully constructed recently, but limited work has been done on concurrent C-to-G and A-to-G base editing. In addition, there is also limited data on how chromatin-associated factors affect the base editing
Externí odkaz:
https://doaj.org/article/69661de188c744f18933a65d1b2079e2
Autor:
Ronghao Chen, Yu Cao, Yajing Liu, Dongdong Zhao, Ju Li, Zhihui Cheng, Changhao Bi, Xueli Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could en
Externí odkaz:
https://doaj.org/article/a9653fd8e62547feadfa9b23d852884b
Autor:
Siwei Li, Jingjing An, Yaqiu Li, Xiagu Zhu, Dongdong Zhao, Lixian Wang, Yonghui Sun, Yuanzhao Yang, Changhao Bi, Xueli Zhang, Meng Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
A large number of cell disease models with pathogenic SNVs are needed. Here the authors report an automated high-throughput platform to perform the genome editing process from gRNA design to the analysis of the editing results; they characterise in s
Externí odkaz:
https://doaj.org/article/22aa95eb82bf4040afecbac13a82f328
Autor:
Junchang Su, Pengju Wang, Ju Li, Dongdong Zhao, Siwei Li, Feiyu Fan, Zhubo Dai, Xiaoping Liao, Zhitao Mao, Chunzhi Zhang, Changhao Bi, Xueli Zhang
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Natural life systems can be significantly modified at the genomic scale by human intervention, demonstrating the great innovation capacity of genome engineering. Large epi-chromosomal DNA structures were established in Escherichia
Externí odkaz:
https://doaj.org/article/7f67eeb6c6344612bd842ae15295c01e
Publikováno v:
mLife, Vol 1, Iss 2, Pp 156-170 (2022)
Abstract Glucose and xylose are two major components of lignocellulose. Simultaneous consumption of glucose and xylose is critical for engineered microorganisms to produce fuels and chemicals from lignocellulosic biomass. Although many production lim
Externí odkaz:
https://doaj.org/article/8004d816b8c141bbb9cc99ad7ee5bfe3
Autor:
Pengju Wang, Dongdong Zhao, Ju Li, Junchang Su, Chunzhi Zhang, Siwei Li, Feiyu Fan, Zhubo Dai, Xiaoping Liao, Zhitao Mao, Changhao Bi, Xueli Zhang
Publikováno v:
Advanced Science, Vol 10, Iss 7, Pp n/a-n/a (2023)
Abstract Synthetic biology has been represented by the creation of artificial life forms at the genomic scale. In this work, a CRISPR‐based chromosome‐doubling technique is designed to first construct an artificial diploid Escherichia coli cell.
Externí odkaz:
https://doaj.org/article/cc8b8fdfccac4af1b15067dbe778bc2c
Publikováno v:
Advanced Science, Vol 9, Iss 26, Pp n/a-n/a (2022)
Abstract Base editing events in eukaryote require a compatible chromatin environment, but there is little research on how chromatin factors contribute to the editing efficiency or window. By engineering BEs (base editors) fused with various pioneer f
Externí odkaz:
https://doaj.org/article/f1d8b201363a460ba9e3c9275e834ef7
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 3, Pp 1130-1147 (2021)
Summary The unconventional yeast Pichia kudriavzevii is renowned for its ability to survive at low pH and has been exploited for the industrial production of various organic acids, especially succinic acid (SA). However, P. kudriavzevii can also util
Externí odkaz:
https://doaj.org/article/fc4ce3c8d592480dbbb7e71f8b1ce782