The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells

Autor: Yakun Luo, Virginie Vlaeminck‐Guillem, Romain Teinturier, Razan Abou Ziki, Philippe Bertolino, Muriel Le Romancer, Chang Xian Zhang

Publikováno v: Cancer Communications, Vol 41, Iss 12, Pp 1427-1430 (2021)

Externí odkaz: https://doaj.org/article/bad364fda9b648918bfa38c434852e27

MEN1 silencing triggers the dysregulation of mTORC1 and MYC pathways in ER+ breast cancer cells

Autor: Razan Abou Ziki, Romain Teinturier, Yakun Luo, Catherine Cerutti, Jean-Marc Vanacker, Coralie Poulard, Thomas Bachelot, Mona Diab-Assaf, Isabelle Treilleux, Chang Xian Zhang, Muriel Le Romancer

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, 2022, 29 (8), pp.451-465. ⟨10.1530/ERC-21-0337⟩
Endocrine-Related Cancer, BioScientifica, 2022, 29 (8), pp.451-465. ⟨10.1530/ERC-21-0337⟩

Menin, encoded by the MEN1 gene, has been identified as a critical factor regulating ESR1 transcription, playing an oncogenic role in ER+ breast cancer (BC) cells. Here, we further dissected the consequences of menin inactivation in ER+ BC cells by f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b588b849c23a2bbf5b8336d2f5a5b193
https://hal.science/hal-03757057

Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling

Autor: Haili Bao, Haibin Wang, Wenbo Deng, Lu Tang, Shuangbo Kong, Meng Liu, Chuanhui Guo, Jinhua Lu, Zhongxian Lu, Chang Xian Zhang, Mengying Liu

During programmed decidualization in rodents, uterine stromal cells undergo extensive cellular and molecular reprograming into morphologically and functionally distinct decidual cells, forming the discrete regions defined as the primary decidual zone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14edf198611ec990c67e7b22f43c00fa
https://doi.org/10.21203/rs.3.rs-839179/v1

MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin

Autor: Muriel Le Romancer, Silvère Baron, Virginie Vlaeminck-Guillem, Yakun Luo, Chang Xian Zhang, Sarah Dallel

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research
Journal of experimental & clinical cancer research, 2021, 40 (1), pp.270. ⟨10.1186/s13046-021-02058-7⟩
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)

Background Recent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent mechanisms in driving metastatic castration-resistant PCa (mCRPC) development and progression. Several p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932cefad117b44b2ad2a124c4be1cc51
https://pubmed.ncbi.nlm.nih.gov/34446068

Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway

Autor: Razan Abou Ziki, Romain Teinturier, Virginie Firlej, Nicolas Gadot, Muriel Le Romancer, Samuele Gherardi, Myriam Decaussin-Petrucci, Virginie Vlaeminck-Guillem, Remy Bonnavion, Philippe Bertolino, F. Vacherot, Yakun Luo, Isabelle Goddard, Chang Xian Zhang

Publikováno v: Oncogene
Oncogene, 2021, 40 (6), pp.1118-1127. ⟨10.1038/s41388-020-01589-1⟩

Dysregulated androgen receptor (AR) plays a crucial role in prostate cancer (PCa) development, though further factors involved in its regulation remain to be identified. Recently, paradoxical results were reported on the implication of the MEN1 gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3689ef40369b5ea2f6feb5c64030784e
https://hal-univ-lyon1.archives-ouvertes.fr/hal-03666659