Výsledky vyhledávání - "Chang-Shung Tung"

Akademický článek

Integrative structural studies of the SARS-CoV-2 spike protein during the fusion process (2022)

Autor: Jacob C. Miner, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Karissa Y. Sanbonmatsu, Chang-Shung Tung

Publikováno v: Current Research in Structural Biology, Vol 4, Iss , Pp 220-230 (2022)

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and catastrophic, worldwide health and economic impacts. The spike protein on the viral surface is responsible for viral entry into the host cell. The binding of spike protein to the host

Externí odkaz: https://doaj.org/article/384dded28dd64ff283f79de4aa7b248b

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Akademický článek

Identification and Characterization of a Class of MALAT1-like Genomic Loci

Autor: Bin Zhang, Yuntao S. Mao, Sarah D. Diermeier, Irina V. Novikova, Eric P. Nawrocki, Tom A. Jones, Zsolt Lazar, Chang-Shung Tung, Weijun Luo, Sean R. Eddy, Karissa Y. Sanbonmatsu, David L. Spector

Publikováno v: Cell Reports, Vol 19, Iss 8, Pp 1723-1738 (2017)

The MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) gene encodes a noncoding RNA that is processed into a long nuclear retained transcript (MALAT1) and a small cytoplasmic tRNA-like transcript (mascRNA). Using an RNA sequence- and str

Externí odkaz: https://doaj.org/article/d062e46877894cd0acc45875f18726f6

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Akademický článek

Modeling the Influenza A NP-vRNA-Polymerase Complex in Atomic Detail

Autor: Jacob C. Miner, Anna Lappala, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Nicolas W. Hengartner, Karissa Y. Sanbonmatsu, Chang-Shung Tung

Publikováno v: Biomolecules, Vol 11, Iss 1, p 124 (2021)

Seasonal flu is an acute respiratory disease that exacts a massive toll on human populations, healthcare systems and economies. The disease is caused by an enveloped Influenza virus containing eight ribonucleoprotein (RNP) complexes. Each RNP incorpo

Externí odkaz: https://doaj.org/article/dd2866bbea854faa8d13e4ff9feb6e21

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Akademický článek

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase

Publikováno v: Cell Reports, Vol 24, Iss 10, Pp 2733-2745.e7 (2018)

Summary: CTP synthase (CTPS) forms compartmentalized filaments in response to substrate availability and environmental nutrient status. However, the physiological role of filaments and mechanisms for filament assembly are not well understood. Here, w

Externí odkaz: https://doaj.org/article/72595cfbc69e420ab2bc36c8b4f98595

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Akademický článek

Functional and Structural Analysis of a Highly-Expressed Yersinia pestis Small RNA following Infection of Cultured Macrophages.

Autor: Nan Li, Scott P Hennelly, Chris J Stubben, Sofiya Micheva-Viteva, Bin Hu, Yulin Shou, Momchilo Vuyisich, Chang-Shung Tung, Patrick S Chain, Karissa Y Sanbonmatsu, Elizabeth Hong-Geller

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168915 (2016)

Non-coding small RNAs (sRNAs) are found in practically all bacterial genomes and play important roles in regulating gene expression to impact bacterial metabolism, growth, and virulence. We performed transcriptomics analysis to identify sRNAs that ar

Externí odkaz: https://doaj.org/article/1b1d0df5ef2e4076a5d3ec9b25a8299d

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Akademický článek

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

Autor: Anna Lappala, Wataru Nishima, Jacob Miner, Paul Fenimore, Will Fischer, Peter Hraber, Ming Zhang, Benjamin McMahon, Chang-Shung Tung

Publikováno v: Biomolecules, Vol 8, Iss 2, p 25 (2018)

Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral

Externí odkaz: https://doaj.org/article/6b3dcf76fe7042d9ba02ddfc024ef92c

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Scaling molecular dynamics beyond 100,000 processor cores for large‐scale biophysical simulations

Autor: Chigusa Kobayashi, Wataru Nishima, Anna Lappala, Will Fischer, Marcus Daniels, Jaewoon Jung, Tamar Schlick, Karissa Y. Sanbonmatsu, Dominic Phillips, Gavin D. Bascom, Yuji Sugita, Chang-Shung Tung, Adetokunbo Adedoyin, Michael E. Wall

Publikováno v: J Comput Chem

The growing interest in the complexity of biological interactions is continuously driving the need to increase system size in biophysical simulations, requiring not only powerful and advanced hardware but adaptable software that can accommodate a lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf049658b724aa4bff403e0981c8ace
https://doi.org/10.1002/jcc.25840

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