Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Chang-Seng Liang"'
Autor:
Deepa M. Gopal, Nir Ayalon, Yi‐Chih Wang, Deborah Siwik, Aaron Sverdlov, Courtney Donohue, Alejandro Perez, Jill Downing, Caroline Apovian, Vanessa Silva, Marcello Panagia, Vijaya Kolachalama, Jennifer E. Ho, Chang‐seng Liang, Noyan Gokce, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 7 (2019)
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease (MHD) in young obese patients would help identify high‐risk individuals for heart failure prevention s
Externí odkaz:
https://doaj.org/article/67aace46baab412d89d4639149c23c25
Autor:
Deborah A. Siwik, Deepa M. Gopal, Wilson S. Colucci, Noyan Gokce, Nir Ayalon, Marcello Panagia, Jill Downing, Chang Seng Liang, Aaron L. Sverdlov, Alejandro J. Perez, Courtney Donohue, Jennifer E. Ho, Vanessa Silva, Yi-Chih Wang, Vijaya B. Kolachalama, Caroline M. Apovian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high‐risk individuals for heart failure prevention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f4af6f6b07360528f42f56b1ecd67
http://europepmc.org/articles/PMC6509711
http://europepmc.org/articles/PMC6509711
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 295:H1956-H1965
The cardiotoxic effects of doxorubicin, a potent chemotherapeutic agent, have been linked to DNA damage, oxidative mitochondrial damage, and nuclear translocation of p53, but the exact molecular mechanisms causing p53 transactivation and doxorubicin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2710c4c616eb895bac950a0da7c90f
https://doi.org/10.1152/ajpheart.00407.2008
https://doi.org/10.1152/ajpheart.00407.2008
Autor:
Huanlei Huang, Chikao Iwai, Weike Mao, Chang-seng Liang, Jiahao Liu, Virendra K. Sharma, Tingchung Wang, Raju Vulapalli, Shey-Shing Sheu, Michael Fu, Shuji Fukuoka
Publikováno v:
Journal of Molecular and Cellular Cardiology. 44:304-314
Auto-antibodies against the beta(1)-adrenoceptors are present in 30-40% of patients with dilated cardiomyopathy. Recently, a synthetic peptide corresponding to a sequence of the second extracellular loop of the human beta(1)-adrenoceptor (beta(1)-EC(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e379b15d97585b01ae1647b8178477
https://doi.org/10.1016/j.yjmcc.2007.11.007
https://doi.org/10.1016/j.yjmcc.2007.11.007
Autor:
Chang-seng Liang
Publikováno v:
Acta Pharmacologica Sinica. 28:921-927
Increased cardiac release of norepinephrine (NE) and depleted cardiac stores of NE are two salient features of the human failing heart. Researchers from my laboratory have shown that these changes are accompanied by a functional defect of NE uptake i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb43d578d9cdd4fa156965339680d69
https://doi.org/10.1111/j.1745-7254.2007.00585.x
https://doi.org/10.1111/j.1745-7254.2007.00585.x
Autor:
Noyan Gokce, Deepa M. Gopal, Wilson S. Colucci, Nir Ayalon, Rajalakshmi Santhanakrishnan, Chang Seng Liang, Courtney Donohue, Jennifer E. Ho, Yi-Chih Wang, Jill Downing, Harpaul Sandhu, Alejandro J. Perez
Background— Despite the substantial overlap of obesity and metabolic disease, there is heterogeneity with respect to cardiovascular risk. We sought to investigate preclinical differences in systolic and diastolic function in obesity, and specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c381b86057a5507ec6f5153ecbb4317a
https://europepmc.org/articles/PMC4573845/
https://europepmc.org/articles/PMC4573845/
Autor:
Wilson S. Colucci, Rajalakshmi Santhanakrishnan, Noyan Gokce, Alejandro J. Perez, Deepa M. Gopal, Chang-seng Liang, Jennifer E. Ho, Yi-Chih Wang, Youssef Rahban, Nir Ayalon, Courtney Donohue, Jill Downing
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Metabolic disease can lead to intrinsic pulmonary hypertension in experimental models. The contributions of metabolic syndrome (MetS) and obesity to pulmonary hypertension and right ventricular dysfunction in humans remain unclear. We inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d410994a961a158d2cd794ce61a2a0
https://pubmed.ncbi.nlm.nih.gov/25758604
https://pubmed.ncbi.nlm.nih.gov/25758604
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H995-H1003
Cardiac sympathetic transmitter stores are reduced in the failing heart. In this study, we proposed to investigate whether the reduction of cardiac sympathetic neurotransmitters was associated with increased interstitial norepinephrine (NE) and react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619892ea9ebad648acea20b8d9d2e8f5
https://doi.org/10.1152/ajpheart.00569.2005
https://doi.org/10.1152/ajpheart.00569.2005
Autor:
Susan C. Brozena, Chang Seng Liang, Westby G. Fisher, James P. Daubert, William T. Abraham, InSync Iii Clinical Study Investigators, John C. Gurley, Angel R. Leon, George Wong
Publikováno v:
Journal of the American College of Cardiology. 46(12):2298-2304
ObjectivesThe InSync III study evaluated sequential cardiac resynchronization therapy (CRT) in patients with moderate-to-severe heart failure and prolonged QRS.BackgroundSimultaneous CRT improves hemodynamic and clinical performance in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db0f1b5cf63b86efde8778890ec62f5
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H1729-H1736
We reported recently that inhibition of neuronal reuptake of norepinephrine (NE) by desipramine prevented the reduction of sympathetic neurotransmitters in the failing right ventricle of right heart failure animals. In this study, we studied whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0af63edccc787475b34da6c95756243
https://doi.org/10.1152/ajpheart.00853.2002
https://doi.org/10.1152/ajpheart.00853.2002