Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Chang-Qin Hu"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Impurities in pharmaceuticals of potentially hazardous materials may cause drug safety problems. Macrolide antibiotic preparations include active pharmaceutical ingredients (APIs) and different types of impurities with similar structures, and the amo
Externí odkaz:
https://doaj.org/article/8d5f24d5611f4f54864a86c992432548
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using s
Externí odkaz:
https://doaj.org/article/6782dd8235ac4127a22fd2e6477d5bab
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Background: The prevalence of non-alcohol fatty liver disease (NAFLD) is increasing in children and adolescents who are mostly resulted from overfeeding. Previous studies demonstrate that berberine (BBR), a compound derived from plant, has beneficial
Externí odkaz:
https://doaj.org/article/a98fd8a1c72c4c6485ffb6c9230f8c58
Publikováno v:
Current Pharmaceutical Analysis. 18:710-718
Background: We systematically characterized an allergic dimer impurity in cefmenoxime hydrochloride raw material by UV, IR, HR-MS, 1D, and 2D NMR for the first time. Methods: The dimer stock solution of cefmenoxime hydrochloride was obtained by the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bae69d9327568bd74199f0b217bc502
https://doi.org/10.2174/1573412918666220318103024
https://doi.org/10.2174/1573412918666220318103024
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
To improve the quality control of drugs, we predicted the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of ceftazidime (CAZ) and its impurities via in silico methods. We used three types of quantitative structure-activity rela
Externí odkaz:
https://doaj.org/article/c129b9b81e2e4e13b165a18167599961
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Herein, we aimed to develop a strategy for evaluating the consistency of pharmaceutically important crystallization processes in real time, focusing on two typical cases of polymorphism. Theoretical analysis using a combination of 13C solid-state nuc
Externí odkaz:
https://doaj.org/article/656674f961104f0a99b0464d257c4bd1
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
The accuracy of quantitative models for near-infrared (NIR) spectroscopy is dependent upon calibration samples with concentration variations. Conventional sample-collection methods have shortcomings (especially time-consumption), which creates a “b
Externí odkaz:
https://doaj.org/article/4b7d460dd93d48c49b499cbc3781f6af
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained fr
Externí odkaz:
https://doaj.org/article/0ec96bbfcfa54547bc5ddbc3ed6a3c3d
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Cefazolin sodium is an essential drug that is widely used in clinical therapy for certain infective diseases caused by bacteria. As drug impurities are considered to be one of the most important causes of drug safety issues, we studied embryotoxicity
Externí odkaz:
https://doaj.org/article/abc5d04190574853acc386eb7715108e
Publikováno v:
Toxicology and Applied Pharmacology. 469:116529
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35401c8b4dcb366580b8b711ec40ce8d
https://doi.org/10.1016/j.taap.2023.116529
https://doi.org/10.1016/j.taap.2023.116529