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Akademický článek

Inhibition of autophagic flux by S-nitrosylation of SQSTM1/p62 promotes neuronal secretion and cell-to-cell transmission of SNCA/α-synuclein in Parkinson disease and Lewy body dementia

Autor: Chang-ki Oh, Tomohiro Nakamura, Stuart A. Lipton

Publikováno v: Autophagy Reports, Vol 1, Iss 1, Pp 223-225 (2022)

Autophagy (in the form of macroautophagy) is the major intracellular protein quality control system for removal of damaged organelles and abnormally aggregated proteins. We and others have shown that dysregulated autophagic pathways contribute to acc

Externí odkaz: https://doaj.org/article/ae22671c56af4512aa4c972b25442b9e

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Akademický článek

NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model

Autor: Shu-ichi Okamoto, Olga Prikhodko, Juan Pina-Crespo, Anthony Adame, Scott R. McKercher, Laurence M. Brill, Nobuki Nakanishi, Chang-ki Oh, Tomohiro Nakamura, Eliezer Masliah, Stuart A. Lipton

Publikováno v: Neurobiology of Disease, Vol 127, Iss , Pp 390-397 (2019)

Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological, cognitive, and behavioral deficits. TSC patients also express co-morbidity with anxiety a

Externí odkaz: https://doaj.org/article/a572bd40338d4b15b09c31e72f6e65cb

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Akademický článek

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome

Autor: Takumi Satoh, Dorit Trudler, Chang-Ki Oh, Stuart A. Lipton

Publikováno v: Antioxidants, Vol 11, Iss 1, p 124 (2022)

Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory repute, is employed in traditional medicines in many countries. Rosemary contains carnosic acid (CA) and carnosol (CS), abietane-type phenolic diterpenes, which a

Externí odkaz: https://doaj.org/article/8b16e0f9e2bb4e149e02ac0db9001a03

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Akademický článek

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

Autor: Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B. McClatchy, Jolene K. Diedrich, John R. Yates, III, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A. Lipton

Publikováno v: Cell Reports, Vol 21, Iss 8, Pp 2171-2182 (2017)

Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson’s disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environ

Externí odkaz: https://doaj.org/article/6cbba4e38c0245ebabf9b742b039a55d

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Akademický článek

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Autor: Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton

Publikováno v: Neurobiology of Disease, Vol 84, Iss , Pp 99-108 (2015)

Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic

Externí odkaz: https://doaj.org/article/f1f59b9dd3d54f7b9aa8622cf6a1bca9

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Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3

Autor: Hongmei Yang, Chang-ki Oh, Haitham Amal, John S. Wishnok, Sarah Lewis, Emily Schahrer, Dorit Trudler, Tomohiro Nakamura, Steven R. Tannenbaum, Stuart A. Lipton

Publikováno v: Science advances, vol 8, iss 50

Protein S-nitros(yl)ation (SNO) is a posttranslational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer’s disease (AD). To identify SNO proteins in AD brains, we used triaryl phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87ea5bfea103d78cb68980531a705ae
https://doi.org/10.1126/sciadv.ade0764

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RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins

Autor: Young J. Oh, Young Ki Choi, Chang-ki Oh, Nuri Yun, Ih-Yeon Hwang

Publikováno v: Journal of Neural Transmission. 129:463-475

Ubiquitination and sumoylation are two important posttranslational modifications in cells. RING (Really Interesting New Gene)-type E3 ligases play essential roles in regulating a plethora of biological processes such as cell survival and death. In ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8ead91606ed6ce3264ceaa30f2b8629
https://doi.org/10.1007/s00702-021-02442-9

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