Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Chang-Kai Sun"'
Autor:
Chun-Ying Liu, Rui-Xin Zhou, Chang-Kai Sun, Ying-Hua Jin, Hong-Shan Yu, Tian-Yang Zhang, Long-Quan Xu, Feng-Xie Jin
Publikováno v:
Journal of Ginseng Research, Vol 39, Iss 3, Pp 221-229 (2015)
Background: Minor ginsenosides, those having low content in ginseng, have higher pharmacological activities. To obtain minor ginsenosides, the biotransformation of American ginseng protopanaxadiol (PPD)-ginsenoside was studied using special ginsenosi
Externí odkaz:
https://doaj.org/article/0bed0accf971477b9bc8f2e8b17ed698
Autor:
Juan Fu, Ya-Wen Fu, Juan-Juan Zhao, Zhi-Xue Yang, Si-Ang Li, Guo-Hua Li, Zi-Jun Quan, Feng Zhang, Jian-Ping Zhang, Xiao-Bing Zhang, Chang-Kai Sun
Publikováno v:
Stem Cell Reviews and Reports. 18:1822-1833
Highly efficient gene knockout (KO) editing of CRISPR–Cas9 has been achieved in iPSCs, whereas homology-directed repair (HDR)-mediated precise gene knock-in (KI) and high-level expression are still bottlenecks for the clinical applications of iPSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9049a885066256d78deaf31a0e687d6f
https://doi.org/10.1007/s12015-022-10331-1
https://doi.org/10.1007/s12015-022-10331-1
Autor:
Cameron Arakaki, Xiao-Bing Zhang, Lu Zhang, Leslie Aranda, Ya-Wen Fu, Tao Cheng, Wei Wen, Guo-Hua Li, Wanqiu Chen, Xiao-Lan Li, Hannah Choi, Juan Fu, Chang-Kai Sun, Prue Talbot, David J. Baylink, Gary D. Botimer, Rachel Bechar, Weisheng V Chen, Mei Zhao, Jian-Ping Zhang
Publikováno v:
Nucleic Acids Research
Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine. However, low editing efficiency has hampered the applications of CRISPR–Cas9 technology in creating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcb005b9dcec73ad700c378666c39d4
https://doi.org/10.1093/nar/gky804
https://doi.org/10.1093/nar/gky804
Autor:
Wei Wen, Weiping Yuan, Jing Xu, Lu Zhang, Fei-Ying Meng, Feng Zhang, Xiao Lan Li, Ya-Wen Fu, Chang-Kai Sun, Gary D. Botimer, Xiao-Bing Zhang, Jian-Ping Zhang, Zhi-Xue Yang, Xin-Xin Cheng, Tao Cheng
Publikováno v:
Stem Cell Reports
Summary We have developed an improved episomal vector system for efficient generation of integration-free induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells. More recently, we reported that the use of an optimized CRISPR-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6691a6a5a448997594d79584a414c31d
https://doi.org/10.1016/j.stemcr.2018.04.013
https://doi.org/10.1016/j.stemcr.2018.04.013
Autor:
Guang H. Yue, Anna Jaskólska, Vinod Sahgal, Ken Hrovat, Yin Fang, Janis J. Daly, Chang-Kai Sun, Artur Jaskólski, Vlodek Siemionow, Katarzyna Kisiel-Sajewicz
Publikováno v:
Neurorehabilitation and Neural Repair. 25:359-368
Background. After hemiparetic stroke, coordination of the shoulder flexor and elbow extensor muscles during a reaching movement is impaired and contributes to poor performance. Objective. The aim was to determine whether functional coupling between e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bbaf023d86b2868b159c3750db228f
https://doi.org/10.1177/1545968310388665
https://doi.org/10.1177/1545968310388665
Publikováno v:
Phytotherapy Research. 25:137-141
Ginkgo biloba extracts (GBE) have long been used as a traditional herbal medicine for treating central nervous system diseases and peripheral vascular diseases, but the underlying mechanisms have yet to be elucidated. Furthermore, traditional GBE is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4f0250c8e796d232b40ef9ce2aa74c
https://doi.org/10.1002/ptr.3235
https://doi.org/10.1002/ptr.3235
Autor:
Dilara Khoshknabi, Vinod Sahgal, Guang H. Yue, Vinoth K. Ranganathan, Declan Walsh, Mellar P. Davis, Chang Kai Sun, Qi Yang, Vlodek Siemionow, Yin Fang
Publikováno v:
Brain Research. 1250:101-112
Objective Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain–muscle coupling has n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33df6302f6512c2253f300bcadc5276
https://doi.org/10.1016/j.brainres.2008.10.074
https://doi.org/10.1016/j.brainres.2008.10.074
Publikováno v:
Chinese Medical Journal. 121:1165-1168
Background Tanis was reported as a putative receptor for serum amyloid A (SAA) involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats (Psammomys obesus, Israeli sand rat) and its homologu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c88c0a0f86dc08d12a4f1b85507d42e5
https://doi.org/10.1097/00029330-200807010-00003
https://doi.org/10.1097/00029330-200807010-00003
Publikováno v:
Chinese Journal of Integrative Medicine. 14:117-122
Objective To investigate the relationship between the excitotoxicity and serum-inducible kinase (SNK) and spine-associated Rap GTPase-activating protein (SPAR) pathway in primary hippocampal neuron injury induced by glutamate and furthermore, to expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514f974ed759d2eb844cea57fcdc0f82
https://doi.org/10.1007/s11655-008-0117-1
https://doi.org/10.1007/s11655-008-0117-1
Publikováno v:
Brain Research. 1168:38-45
The serum-induced kinase (Snk)-spine-associated Rap GTPase-activating protein (SPAR) signaling pathway is reported as a new molecular mechanism in activity-dependent remodeling of synapses. However, the relationship between Snk-SPAR pathway and gluta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424d4e388370685f5767f76f0ac072c6
https://doi.org/10.1016/j.brainres.2007.06.082
https://doi.org/10.1016/j.brainres.2007.06.082