Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chang-K. Shim"'
Autor:
H.J. Lee, S.H. Kim, Sihyung Yang, M.G. Lee, Hee Eun Kang, Chang-K. Shim, Jung Hee Suh, In-Soo Yoon
Publikováno v:
Xenobiotica. 41:885-894
Protein-calorie malnutrition (PCM) occurs frequently in advanced cancer patients and has a profound impact on the toxicity of many drugs. Thus, the pharmacokinetics of etoposide were evaluated in control, control with cysteine (CC), PCM, and PCM with
Publikováno v:
Biopharmaceutics & Drug Disposition. 28:485-490
The hypothesis that higher molecular weight (MW) quaternary ammoniums (QAs) form lipophilic ion-pair complexes with bile salts in the liver, and are subsequently excreted into bile via a canalicular transporter, P-gp, was re-examined in the present s
Autor:
Suk-J. Chung, Jong W. Kwon, Ae K. Lee, Chang-K. Shim, Sang G. Kim, Inchul Lee, Soo K. Bae, Dae Y. Lee, Myung Gyoon Lee
Publikováno v:
Journal of Pharmaceutical Sciences. 93:2388-2398
Effects of cysteine on the pharmacokinetics of torasemide were investigated after intravenous administration at a dose of 2 mg/kg to control rats and rats with PCM and PCMC. Torasemide was reported to be mainly metabolized via hepatic CYP2C9 in human
Autor:
Myung Gyoon Lee, Jong W. Kwon, Suk Jae Chung, Eun Jeong Kim, Sang G. Kim, Choong Y. Ahn, Chang-K. Shim
Publikováno v:
Life Sciences. 73:1783-1794
Effects of cysteine on the pharmacokinetics of clarithromycin were investigated after intravenous administration of the drug at a dose of 20 mg/kg to control rats (4-week fed on 23% casein diet) and rats with PCM (protein-calorie malnutrition, 4-week
Publikováno v:
Pharmacologytherapeutics. 138(1)
More than 40% of clinically used drugs are organic cations (OCs), which are positively charged at a physiologic pH, and recent reports have established that these drugs are substrates of membrane transporters. The transport of OCs via membrane transp
Publikováno v:
International Journal of Pharmaceutics. 131:91-96
The inverse-targeting of reticuloendothelial system (RES)-rich organs was compared after intravenous (i.v.) injection of free adriamycin, ADM (treatment I) and ADM-loaded neutral proliposomes containing poloxamer 407 (treatment II), 16 mg per kg as f
Publikováno v:
International Journal of Pharmaceutics. 121:1-10
The pharmacokinetics and tissue distribution of adriamycin (ADM) and its metabolite, adriamycinol were investigated after intravenous (i.v.) injection of free ADM (treatment I), ADM-loaded neutral proliposomes (treatment II) and empty neutral prolipo
Publikováno v:
Biopharmaceutics & Drug Disposition. 15:391-407
The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX-loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 39(2)
1. The purpose of this study was to investigate the involvement of rat Mrp2 and human MRP2 in benzylpenicillin transport using canalicular liver plasma membrane (cLPM) vesicles isolated from Sprague-Dawley or Easai hyperbilirubinemic (EHBR) rats, and
Autor:
Suk Jae Chung, Eun Jeong Kim, Sang G. Kim, Choong Y. Ahn, Myung Gyoon Lee, Jong W. Kwon, Ae K. Lee, Chang-K. Shim
Publikováno v:
Biopharmaceuticsdrug disposition. 24(2)
The effects of cysteine on the pharmacokinetics of itraconazole were investigated after intravenous, 20 mg/kg, and oral, 50 mg/kg, administration of the drug to control rats (fed for 4 weeks on 23% casein diet) and rats with PCM (protein-calorie maln