Transcriptional profiles in olfactory pathway–associated brain regions of African green monkeys: Associations with age and Alzheimer's disease neuropathology

Autor: Jacob D. Negrey, Dorothy L. Dobbins, Timothy D. Howard, Karin E. Borgmann‐Winter, Chang‐Gyu Hahn, Sergey Kalinin, Douglas L. Feinstein, Suzanne Craft, Carol A. Shively, Thomas C. Register

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)

Abstract Introduction Olfactory impairment in older individuals is associated with an increased risk of Alzheimer's disease (AD). Characterization of age versus neuropathology‐associated changes in the brain olfactory pathway may elucidate processe

Externí odkaz: https://doaj.org/article/5cc804fc23024e03a221c78750ca0ff7

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

Autor: Kiran, Girdhar, Gabriel E, Hoffman, Jaroslav, Bendl, Samir, Rahman, Pengfei, Dong, Will, Liao, Mads E, Hauberg, Laura, Sloofman, Leanne, Brown, Olivia, Devillers, Bibi S, Kassim, Jennifer R, Wiseman, Royce, Park, Elizabeth, Zharovsky, Rivky, Jacobov, Elie, Flatow, Alexey, Kozlenkov, Thomas, Gilgenast, Jessica S, Johnson, Lizette, Couto, Mette A, Peters, Jennifer E, Phillips-Cremins, Chang-Gyu, Hahn, Raquel E, Gur, Carol A, Tamminga, David A, Lewis, Vahram, Haroutunian, Stella, Dracheva, Barbara K, Lipska, Stefano, Marenco, Marija, Kundakovic, John F, Fullard, Yan, Jiang, Panos, Roussos, Schahram, Akbarian

Publikováno v: Girdhar, K, Hoffman, G E, Bendl, J, Rahman, S, Dong, P, Liao, W, Hauberg, M E, Sloofman, L, Brown, L, Devillers, O, Kassim, B S, Wiseman, J R, Park, R, Zharovsky, E, Jacobov, R, Flatow, E, Kozlenkov, A, Gilgenast, T, Johnson, J S, Couto, L, Peters, M A, Phillips-Cremins, J E, Hahn, C G, Gur, R E, Tamminga, C A, Lewis, D A, Haroutunian, V, Dracheva, S, Lipska, B K, Marenco, S, Kundakovic, M, Fullard, J F, Jiang, Y, Roussos, P, Akbarian, S & PsychENCODE Consortium 2022, ' Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains ', Nature Neuroscience, vol. 25, no. 4, pp. 474-483 . https://doi.org/10.1038/s41593-022-01032-6

Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcb8bfeefa9fbf3ab86dae77f8e36dd
https://doi.org/10.1038/s41593-022-01032-6

Maintenance of Wellness in Patients With Obsessive-Compulsive Disorder Who Discontinue Medication After Exposure/Response Prevention Augmentation: A Randomized Clinical Trial

Autor: Edna B. Foa, Helen Blair Simpson, Thea Gallagher, Michael G. Wheaton, Marina Gershkovich, Andrew B. Schmidt, Jonathan D. Huppert, Patricia Imms, Raphael B. Campeas, Shawn Cahill, Christina DiChiara, Steven D. Tsao, Anthony Puliafico, Daniel Chazin, Anu Asnaani, Kelly Moore, Jeremy Tyler, Shari A. Steinman, Arturo Sanches-LaCay, Sandy Capaldi, Ívar Snorrason, Elizabeth Turk-Karan, Donna Vermes, Eyal Kalanthroff, Anthony Pinto, Gabriella E. Hamlett, Rachel Middleton, Chang-Gyu Hahn, Bin Xu, Page E. Van Meter, Martha Katechis, David Rosenfield

Publikováno v: JAMA Psychiatry

IMPORTANCE: Serotonin reuptake inhibitors (SRIs) are the only medications approved for obsessive-compulsive disorder (OCD), yet most patients taking SRIs exhibit significant symptoms. Adding exposure/response prevention (EX/RP) therapy improves sympt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817115f15a844c69d0520ea7f2ecca15
https://europepmc.org/articles/PMC8792795/

Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease

Autor: Katelyn R. Ward, Steven J. Siegel, Raymond L. Gifford, Robert E. Featherstone, Karin E. Borgmann-Winter, Melissa J. Naschek, Anamika Banerjee, Chang-Gyu Hahn, Olga Melnychenko, Michael W. Salter, Janice Yi

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93:84-92

Much evidence suggests that hypofunction of the N-methyl- d -aspartate glutamate receptor (NMDAR) may contribute broadly towards a subset of molecular, cognitive and behavioral abnormalities common among psychiatric and developmental diseases. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd63ee1d74b951660d5618741914f0d
https://doi.org/10.1016/j.pnpbp.2019.02.017

Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

Autor: Xiaojun Wu, James Reigle, Erica A K DePasquale, James H. Meador-Woodruff, Vahram Haroutunian, Rammohan Shukla, Emily Devine, Margaret Hahn, Micah Simmons, Christy Au-Yeung, Khaled Alganem, Jarek Meller, Chang-Gyu Hahn, Xiaolu Zhang, Hunter M. Eby, Roshanak Asgariroozbehani, Robert E. McCullumsmith

Publikováno v: Molecular psychiatry. 26(12)

While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in brain samples with techniques that may attribute perturbations to specific cell types. To fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac833ff095fae4b1578dd65e7ecd839
https://pubmed.ncbi.nlm.nih.gov/34272489