Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chang-Chun D Lee"'
Autor:
Chang-Chun D Lee, Yasunori Watanabe, Nicholas C Wu, Julianna Han, Sonu Kumar, Tossapol Pholcharee, Gemma E Seabright, Joel D Allen, Chih-Wei Lin, Ji-Rong Yang, Ming-Tsan Liu, Chung-Yi Wu, Andrew B Ward, Max Crispin, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009407 (2021)
Incessant antigenic evolution enables the persistence and spread of influenza virus in the human population. As the principal target of the immune response, the hemagglutinin (HA) surface antigen on influenza viruses continuously acquires and replace
Externí odkaz:
https://doaj.org/article/33e774135c4b47ed9aea851ca8a7a514
Autor:
Nicholas C Wu, Meng Yuan, Sandhya Bangaru, Deli Huang, Xueyong Zhu, Chang-Chun D Lee, Hannah L Turner, Linghang Peng, Linlin Yang, Dennis R Burton, David Nemazee, Andrew B Ward, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009089 (2020)
Epitopes that are conserved among SARS-like coronaviruses are attractive targets for design of cross-reactive vaccines and therapeutics. CR3022 is a SARS-CoV neutralizing antibody to a highly conserved epitope on the receptor binding domain (RBD) on
Externí odkaz:
https://doaj.org/article/7a26590600364280b6b438a6bfd964df
Autor:
Nicholas C. Wu, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Xueyong Zhu, Sandhya Bangaru, Jonathan L. Torres, Tom G. Caniels, Philip J.M. Brouwer, Marit J. van Gils, Rogier W. Sanders, Andrew B. Ward, Ian A. Wilson
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108274- (2020)
Summary: IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 because of structural co
Externí odkaz:
https://doaj.org/article/6bf6b5594a8547aba5c424f38aad6fb7
Autor:
Seth J. Zost, Juhye Lee, Megan E. Gumina, Kaela Parkhouse, Carole Henry, Nicholas C. Wu, Chang-Chun D. Lee, Ian A. Wilson, Patrick C. Wilson, Jesse D. Bloom, Scott E. Hensley
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4460-4470.e8 (2019)
Summary: Antibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly reactive because their footprints are typically large and extend to nearby variable HA residues. Here, we identify
Externí odkaz:
https://doaj.org/article/e5ef4f195b5a4b32bd4bcefba23a1917
Autor:
Cherrelle Dacon, Courtney Tucker, Linghang Peng, Chang-Chun D. Lee, Ting-Hui Lin, Meng Yuan, Yu Cong, Lingshu Wang, Lauren Purser, Jazmean K. Williams, Chul-Woo Pyo, Ivan Kosik, Zhe Hu, Ming Zhao, Divya Mohan, Andrew J. R. Cooper, Mary Peterson, Jeff Skinner, Saurabh Dixit, Erin Kollins, Louis Huzella, Donna Perry, Russell Byrum, Sanae Lembirik, David Drawbaugh, Brett Eaton, Yi Zhang, Eun Sung Yang, Man Chen, Kwanyee Leung, Rona S. Weinberg, Amarendra Pegu, Daniel E. Geraghty, Edgar Davidson, Iyadh Douagi, Susan Moir, Jonathan W. Yewdell, Connie Schmaljohn, Peter D. Crompton, Michael R. Holbrook, David Nemazee, John R. Mascola, Ian A. Wilson, Joshua Tan
Publikováno v:
Science. 377:728-735
The potential for future coronavirus outbreaks highlights the need to broadly target this group of pathogens. We used an epitope-agnostic approach to identify six monoclonal antibodies that bind to spike proteins from all seven human-infecting corona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00be51410add1f540a8cd59d08b048c3
https://doi.org/10.1126/science.abq3773
https://doi.org/10.1126/science.abq3773
Autor:
Nicholas C. Wu, Xueyong Zhu, Marit J. van Gils, Jakob Kreye, Chang-Chun D Lee, Linghang Peng, Hejun Liu, Meng Yuan, Abigail M. Jackson, Dennis R. Burton, Andrew B. Ward, Rogier W. Sanders, David Nemazee, S. Momsen Reincke, Harald Prüss, Ian A. Wilson, Deli Huang
Publikováno v:
Science 373(6556), 818-823 (2021). doi:10.1126/science.abh1139
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 373(6556), 818-823. American Association for the Advancement of Science
Science (New York, N.y.)
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 373(6556), 818-823. American Association for the Advancement of Science
Science (New York, N.y.)
The protective efficacy of neutralizing antibodies (nAbs) elicited during natural infection with SARS-CoV-2 and by vaccination based on its spike protein has been compromised with emergence of the recent SARS-CoV-2 variants. Residues E484 and K417 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a44f112f84d84b18800a45c2c75d8b9
http://www.scopus.com/inward/record.url?scp=85112522453&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85112522453&partnerID=8YFLogxK
Autor:
Huibin Lv, Ray T. Y. So, Qi Wen Teo, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Garrick K. Yip, Wilson W. Ng, Ian A. Wilson, Malik Peiris, Nicholas C. Wu, Chris Ka Pun Mok
Publikováno v:
Viruses; Volume 14; Issue 7; Pages: 1382
Antigenic imprinting, which describes the bias of the antibody response due to previous immune history, can influence vaccine effectiveness. While this phenomenon has been reported for viruses such as influenza, there is little understanding of how p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1277ecad8587c2d665021689263b415
Autor:
Nicholas C. Wu, Thomas F. Rogers, Chang-Chun D Lee, Xueyong Zhu, Fangzhu Zhao, Devin Sok, Henry Tien, Meng Yuan, Joseph G. Jardine, Deli Huang, Dennis R. Burton, Wenli Yu, Hejun Liu, Ian A. Wilson, Yuanzi Hua, Elise Landais
Publikováno v:
Science
A common theme in antibody responses In the fight against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), antibodies are a key tool, both as potential therapeutics and to guide vaccine development. Yuan et al. focused on finding shared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7abd62901afb9a691afd14a50a1985f
https://doi.org/10.1126/science.abd2321
https://doi.org/10.1126/science.abd2321
Autor:
Cherrelle Dacon, Linghang Peng, Ting-Hui Lin, Courtney Tucker, Chang-Chun D. Lee, Yu Cong, Lingshu Wang, Lauren Purser, Andrew J.R. Cooper, Jazmean K. Williams, Chul-Woo Pyo, Meng Yuan, Ivan Kosik, Zhe Hu, Ming Zhao, Divya Mohan, Mary Peterson, Jeff Skinner, Saurabh Dixit, Erin Kollins, Louis Huzella, Donna Perry, Russell Byrum, Sanae Lembirik, Michael Murphy, Yi Zhang, Eun Sung Yang, Man Chen, Kwanyee Leung, Rona S. Weinberg, Amarendra Pegu, Daniel E. Geraghty, Edgar Davidson, Benjamin J. Doranz, Iyadh Douagi, Susan Moir, Jonathan W. Yewdell, Connie Schmaljohn, Peter D. Crompton, John R. Mascola, Michael R. Holbrook, David Nemazee, Ian A. Wilson, Joshua Tan
Publikováno v:
Cell Host & Microbe. 31:97-111.e12
Humanity has faced three recent outbreaks of novel betacoronaviruses, emphasizing the need to develop approaches that broadly target coronaviruses. Here, we identify 55 monoclonal antibodies from COVID-19 convalescent donors that bind diverse betacor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77185091c7456f32bf2e797540c45b1f
https://doi.org/10.1016/j.chom.2022.10.010
https://doi.org/10.1016/j.chom.2022.10.010
Autor:
Chang-Chun D Lee, Carole Henry, Juhye M. Lee, Seth J. Zost, Nicholas C. Wu, Ian A. Wilson, Kaela Parkhouse, Megan E. Gumina, Jesse D. Bloom, Scott E. Hensley, Patrick C. Wilson
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4460-4470.e8 (2019)
Cell reports
Cell reports
SUMMARY Antibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly reactive because their footprints are typically large and extend to nearby variable HA residues. Here, we identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f336325eee91285092bcd0ab49baaea
http://www.sciencedirect.com/science/article/pii/S221112471931575X
http://www.sciencedirect.com/science/article/pii/S221112471931575X