Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Chang Xian Zhang"'
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Akademický článek
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin
Autor: Yakun Luo, Virginie Vlaeminck-Guillem, Silvère Baron, Sarah Dallel, Chang Xian Zhang, Muriel Le Romancer
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Abstract Background Recent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent mechanisms in driving metastatic castration-resistant PCa (mCRPC) development and progression.
Externí odkaz: https://doaj.org/article/11dda5d5a85444298061d91a5c9e8306
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3
Akademický článek
Both PAX4 and MAFA are expressed in a substantial proportion of normal human pancreatic alpha cells and deregulated in patients with type 2 diabetes.
Autor: Rémy Bonnavion, Rami Jaafar, Julie Kerr-Conte, Fouzia Assade, Esther van Stralen, Emmanuelle Leteurtre, Célio Pouponnot, Sofia Gargani, François Pattou, Philippe Bertolino, Martine Cordier-Bussat, Jieli Lu, Chang Xian Zhang
Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72194 (2013)
Pax4 and MafA (v-maf musculoaponeurotic fibrosarcoma oncogene homolog A) are two transcription factors crucial for normal functions of islet beta cells in the mouse. Intriguingly, recent studies indicate the existence of notable difference between hu
Externí odkaz: https://doaj.org/article/0be19846c33a4159930cbefa9ae61f41
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4
MEN1 silencing triggers the dysregulation of mTORC1 and MYC pathways in ER+ breast cancer cells
Autor: Razan Abou Ziki, Romain Teinturier, Yakun Luo, Catherine Cerutti, Jean-Marc Vanacker, Coralie Poulard, Thomas Bachelot, Mona Diab-Assaf, Isabelle Treilleux, Chang Xian Zhang, Muriel Le Romancer
Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, 2022, 29 (8), pp.451-465. ⟨10.1530/ERC-21-0337⟩
Endocrine-Related Cancer, BioScientifica, 2022, 29 (8), pp.451-465. ⟨10.1530/ERC-21-0337⟩
Menin, encoded by the MEN1 gene, has been identified as a critical factor regulating ESR1 transcription, playing an oncogenic role in ER+ breast cancer (BC) cells. Here, we further dissected the consequences of menin inactivation in ER+ BC cells by f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b588b849c23a2bbf5b8336d2f5a5b193
https://hal.science/hal-03757057
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5
Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations
Autor: Razan Abou Ziki, Yakun Luo, Chang Xian Zhang, Muriel Le Romancer, Virginie Vlaeminck-Guillem
Publikováno v: Endocrines. 1:58-81
MEN1 mutation predisposes patients to multiple endocrine neoplasia type 1 (MEN1), a genetic syndrome associated with the predominant co-occurrence of endocrine tumors. Intriguingly, recent evidence has suggested that MEN1 could also be involved in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::346eb2c32a55628cd87f8c4a4aecc093
https://doi.org/10.3390/endocrines1020007
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6
Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling
Autor: Haili Bao, Haibin Wang, Wenbo Deng, Lu Tang, Shuangbo Kong, Meng Liu, Chuanhui Guo, Jinhua Lu, Zhongxian Lu, Chang Xian Zhang, Mengying Liu
During programmed decidualization in rodents, uterine stromal cells undergo extensive cellular and molecular reprograming into morphologically and functionally distinct decidual cells, forming the discrete regions defined as the primary decidual zone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14edf198611ec990c67e7b22f43c00fa
https://doi.org/10.21203/rs.3.rs-839179/v1
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8
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin
Autor: Muriel Le Romancer, Silvère Baron, Virginie Vlaeminck-Guillem, Yakun Luo, Chang Xian Zhang, Sarah Dallel
Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research
Journal of experimental & clinical cancer research, 2021, 40 (1), pp.270. ⟨10.1186/s13046-021-02058-7⟩
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Background Recent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent mechanisms in driving metastatic castration-resistant PCa (mCRPC) development and progression. Several p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932cefad117b44b2ad2a124c4be1cc51
https://pubmed.ncbi.nlm.nih.gov/34446068
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9
Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes
Autor: Romain Teinturier, Chang Xian Zhang, Thomas Bachelot, Laura Corbo, Loay Kassem, Lucie Malbeteau, Yakun Luo, Muriel Le Romancer, Razan Abou Ziki, Isabelle Treilleux, Philippe Bertolino, Samuele Gherardi
Publikováno v: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, 2021, 190 (3), pp.389-401. ⟨10.1007/s10549-021-06339-9⟩
Purpose Menin, encoded by the MEN1 gene, was recently reported to be involved in breast cancers, though the underlying mechanisms remain elusive. In the current study, we sought to further determine its role in mammary cells. Methods Menin expression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161a5bbb1c14f0e479e4c0aba987cfb3
https://pubmed.ncbi.nlm.nih.gov/34561764
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10
Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway
Autor: Razan Abou Ziki, Romain Teinturier, Virginie Firlej, Nicolas Gadot, Muriel Le Romancer, Samuele Gherardi, Myriam Decaussin-Petrucci, Virginie Vlaeminck-Guillem, Remy Bonnavion, Philippe Bertolino, F. Vacherot, Yakun Luo, Isabelle Goddard, Chang Xian Zhang
Publikováno v: Oncogene
Oncogene, 2021, 40 (6), pp.1118-1127. ⟨10.1038/s41388-020-01589-1⟩
Dysregulated androgen receptor (AR) plays a crucial role in prostate cancer (PCa) development, though further factors involved in its regulation remain to be identified. Recently, paradoxical results were reported on the implication of the MEN1 gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3689ef40369b5ea2f6feb5c64030784e
https://hal-univ-lyon1.archives-ouvertes.fr/hal-03666659
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