Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Chang Seob Kwon"'
Autor:
Soyun Lee, Seunghee Oh, Kwiwan Jeong, Hyelim Jo, Yoonjung Choi, Hogyu David Seo, Minhoo Kim, Joonho Choe, Chang Seob Kwon, Daeyoup Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed reg
Externí odkaz:
https://doaj.org/article/212d26a446b048c1a4d3006d7bb52b5b
Publikováno v:
Protein & Cell, Vol 7, Iss 2, Pp 100-113 (2015)
ABSTRACT The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals
Externí odkaz:
https://doaj.org/article/5bfe4af30cd14da590da2f7b6ebb72df
Publikováno v:
Biochemical and Biophysical Research Communications. 476:515-521
Nucleosome dynamics facilitated by histone turnover is required for transcription as well as DNA replication and repair. Histone turnover is often associated with various histone modifications such as H3K56 acetylation (H3K56Ac), H3K36 methylation (H
Publikováno v:
Current genetics. 64(3)
Accumulating evidence shows that non-proteolytic functions of the proteasome are as crucial as its well-known proteolytic function in regulating cellular activities. In our recent work, we showed that the 19S proteasome mediates the heterochromatin s
Autor:
Yong-Sung Kim, Hosuk Lee, Daeyoup Lee, Yong-Mahn Han, Seung Kyoon Kim, Kwiwan Jeong, Chang Seob Kwon, Inkyung Jung, Dongsup Kim, Mirang Kim, Keunsoo Kang
Publikováno v:
Journal of Biological Chemistry. 287:39698-39709
Histone-modifying enzymes play a pivotal role in gene expression and repression. In human, DOT1L (Dot1-like) is the only known histone H3 lysine 79 methyltransferase. hDOT1L is associated with transcriptional activation, but the general mechanism con
Publikováno v:
The Plant Pathology Journal. 27:170-182
Plants possess multiple resistance mechanisms that protect themselves against pathogen attack. To identify unknown components of the defense machinery in Arabidopsis, gene-expression changes were monitored in Arabidopsis thaliana under 18 different b
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 61:1123-1126
A Gram-staining-positive, coccus-shaped, non-spore-forming, facultatively anaerobic bacterium, designated AC-1T, was isolated from an acidogenic fermentation bioreactor treating food wastewater. On the basis of 16S rRNA gene sequence analysis, strain
Publikováno v:
Biochemical and Biophysical Research Communications. 399:512-517
Dot1p is involved in maintenance of the heterochromatin boundary, the DNA damage response, and transcriptional regulation in yeast and animals. Dot1p is a histone H3 lysine 79 (H3K79) methyltransferase, but H3K79 trimethylation (H3K79me3) by Dot1p re
Autor:
Doris Wagner, Chang Seob Kwon
Publikováno v:
Trends in Genetics. 23:403-412
SWI/SNF chromatin remodeling ATPases control accessibility of the information stored in the genome. However, the in vivo role of these remodelers has remained poorly understood because null mutations in these result in embryonic lethality in most org
Autor:
Chang Seob Kwon, Mitsuhiro Aida, Masao Tasaka, Doris Wagner, Staver Bezhani, Jennifer Pfluger, Ken-ichiro Hibara, Heral Metha
Publikováno v:
Development. 133:3223-3230
The CUP-SHAPED COTYLEDON (CUC) genes CUC1, CUC2 and CUC3act redundantly to control cotyledon separation in Arabidopsis. In order to identify novel regulators of this process, we have performed a phenotypical enhancer screen using a null allele of cuc