Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Chang H, Park"'
Autor:
Stephen K. Tahir, Morey L. Smith, Paul Hessler, Lisa Roberts Rapp, Kenneth B. Idler, Chang H. Park, Joel D. Leverson, Lloyd T. Lam
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy. It is also b
Externí odkaz:
https://doaj.org/article/50dd38d90f7d492b9bcfd36f4735ec83
Autor:
Chang H. Park, Garrett W. Burnett
Publikováno v:
Cambridge Handbook of Anesthesiology ISBN: 9781108936941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dff0b997001cb7c639314f60c5af738
https://doi.org/10.1017/9781108936941.008
https://doi.org/10.1017/9781108936941.008
Publikováno v:
Spine Deformity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a372b36d8227a4c029220c6801029f4f
https://doi.org/10.1007/s43390-023-00699-6
https://doi.org/10.1007/s43390-023-00699-6
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Daniel H. Albert, Wei Qiu, Chang H. Park, Steven D. Fidanze, Lisa A. Hasvold, Maricel Torrent, Ganesh Rajaraman, Xiaoli Huang, Peter Kovar, Keith F. McDaniel, Xiaoyu Lin, George S. Sheppard, Le Wang, John K. Pratt, Lu Zhang, Mai Bui, Yu Shen, Kenton L. Longenecker, Warren M. Kati, Dachun Liu, Denise Wilcox, Terrance J. Magoc, Emily J. Faivre
Publikováno v:
Journal of Medicinal Chemistry. 63:5585-5623
The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under clinical development for on...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13664ab18da232a44d2b0a2ef1e6c65
https://doi.org/10.1021/acs.jmedchem.0c00628
https://doi.org/10.1021/acs.jmedchem.0c00628
Autor:
Paul Nimmer, Erwin R. Boghaert, Robin R. Frey, Phuong N Le, Andrew J. Souers, Peter Kovar, Wenqing Gao, Deepak Sampath, Dolores Diaz, Haichao Zhang, T. Matthew Hansen, Michael J. Mitten, Stephen K. Tahir, Russell A. Judge, Edna F. Choo, Yu Xiao, Shashank Shekhar, Xiaohong Song, George Doherty, Zhi-Fu Tao, Andrew S. Judd, Wayne J. Fairbrother, Michael D. Wendt, Steven W. Elmore, Kunzer Aaron R, Le Wang, Xilu Wang, Darren C. Phillips, Morey L. Smith, John A. Flygare, John Xue, Joel D. Leverson, Milan Bruncko, Chang H. Park, Nathaniel D. Catron
Publikováno v:
ACS Medicinal Chemistry Letters
Herein we describe the discovery of A-1331852, a first-in-class orally active BCL-XL inhibitor that selectively and potently induces apoptosis in BCL-XL-dependent tumor cells. This molecule was generated by re-engineering our previously reported BCL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85af09593f6d81ea66757099b5fec23d
http://europepmc.org/articles/PMC7549103
http://europepmc.org/articles/PMC7549103
Autor:
Denise Wilcox, Vasudha Sehgal, Daniel H. Albert, John K. Pratt, Keith F. McDaniel, Xin Lu, Chaohong Sun, Dachun Liu, Joshua P. Plotnik, Srinivasa R. Mantena, Emily J. Faivre, Lisa A. Hasvold, George S. Sheppard, Xiaoli Huang, Le Wang, Lance J Bigelow, Stacey Fossey, Steve D. Fidanze, Lloyd T. Lam, Chang H. Park, Sanjay C. Panchal, Warren M. Kati, John J. Nicolette, Richard J. Bellin, Gaurav Mehta, Xiaoyu Lin, Mai H. Bui, Lu Zhang, Paul Hessler, Maricel Torrent, Tamar Uziel, Saul H. Rosenberg, Yu Shen, Kenton L. Longenecker
Publikováno v:
Nature. 578:306-310
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8040bf69aa34810391b9a59139a83026
https://doi.org/10.1038/s41586-020-1930-8
https://doi.org/10.1038/s41586-020-1930-8
Autor:
Darren C. Phillips, Gary J. Jenkins, Richard S. Hong, Chang H. Park, Richard A. Marks, Rohinton P. Edalji, Russell A. Judge, Geoff G. Z. Zhang, Nathaniel D. Catron, Jie Chen, Ahmed Salem, Ahmad Y. Sheikh, John C. Kalvass, Kaid C. Harper, Rajeev M. Menon, Kennan C. Marsh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Ahmed A. Suleiman, Yu-Ming Pu, Yi Shi, Keith M. Fournier, Zhi-Fu Tao, DeAnne Stolarik, Shuang Chen, Orlando F. Bueno, Xilu Wang, Jianguo Ji, Yi-Yin Ku, Andrew J. Souers, Joel D. Leverson, Russell C. Klix, Steven W. Elmore
Publikováno v:
Molecular cancer therapeutics. 20(6)
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ca7b4ca005bb0064352f56f806f877
https://pubmed.ncbi.nlm.nih.gov/33785651
https://pubmed.ncbi.nlm.nih.gov/33785651
Autor:
Alan Sim, Joshua Hamburger, Benjamin Salter, Garrett Burnett, Jaime B. Hyman, Elisha Dickstein, Daniel Katz, Andrew B. Leibowitz, Matthew A. Levin, Chang H. Park, Robert M. Owen
Publikováno v:
Journal of Anesthesia
In March 2020, the New York City metropolitan area became the epicenter of the United States' SARS-CoV-2 pandemic and the surge of new cases threatened to overwhelm the area's hospital systems. This article describes how an anesthesiology department
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b616f992e379d9c93e1793aaf43dfb2c
https://pubmed.ncbi.nlm.nih.gov/33006071
https://pubmed.ncbi.nlm.nih.gov/33006071