Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chang Geng Peng"'
Autor:
Christian Wolfrum, Nikolay V. Dokholyan, Gang Wang, Valerie A. Clausen, Julia Hettinger, Svetlana Shulga Morskaya, Qianfan Wang, Joshua Brodsky, Verbena Kosovrasti, Xuemei Zhang, Dinah W.Y. Sah, Mike Meys, Kallanthottathil G. Rajeev, Yupang Fang, Muthiah Manoharan, Jennifer Sharman, Martin Maier, Feng Ding, Mariano Severgnini, Victor Kotelianski, Lubomir Tchangov, Renta Hutabarat, Chang Geng Peng, Robert Li, Tim Racie, Lubomir Nechev, James Butler, Tomoko Nakayama, Scott A Barros, Alfica Sehgal, Markus Stoffel
Publikováno v:
Molecular Therapy, 20 (8)
Molecular Therapy
MOLECULAR THERAPY
Molecular Therapy
MOLECULAR THERAPY
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of the corresponding pathogenic protein. The major challenge
Autor:
Victor Koteliansky, Anja Zeigerer, Roman L. Bogorad, Chang Geng Peng, Jerome Gilleron, Sarah Seifert, Jan G. Hengstler, Satya Kuchimanchi, Perla Del Conte-Zerial, Yannis Kalaidzidis, Hila Epstein-Barash, Giovanni Marsico, Vera M. Ruda, Marino Zerial, Hidenori Nonaka
Publikováno v:
Nature. 485:465-470
An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endo
Autor:
Md. Rowshon Alam, Haripriya Addepalli, Shigeo Matsuda, Kallanthottathil G. Rajeev, K. Charisse, Chang Geng Peng, Mitsuo Sekine, Takeshi Yamada, K. Mills, K. N. Jayaprakash, Martin Maier, Muthiah Manoharan
Publikováno v:
The Journal of Organic Chemistry. 76:1198-1211
We have previously demonstrated that conjugation of small molecule ligands to small interfering RNAs (siRNAs) and anti-microRNAs results in functional siRNAs and antagomirs in vivo. Here we report on the development of an efficient chemical strategy
Autor:
K. N. Jayaprakash, Muthiah Manoharan, Kallanthottathil G. Rajeev, Martin Maier, Jos P. Varghese, David Butler, Chang Geng Peng
Publikováno v:
Organic Letters. 12:5410-5413
Novel non-nucleoside alkyne monomers compatible with oligonucleotide synthesis were designed, synthesized, and efficiently incorporated into RNA and RNA analogues during solid-phase synthesis. These modifications allowed site-specific conjugation of
Autor:
Masad J. Damha, Chang Geng Peng
Publikováno v:
Nucleic Acids Research
The impact of 2'-deoxy-2'-fluoroarabinonucleotide residues (2'F-araN) on different G-quadruplexes derived from a thrombin-binding DNA aptamer d(G2T2G2TGTG2T2G2), an anti-HIV phosphorothioate aptamer PS-d(T2G4T2) and a DNA telomeric sequence d(G4T4G4)
Autor:
Masad J. Damha, Chang Geng Peng
Publikováno v:
Nucleic Acids Research. 33:7019-7028
We report the first investigation of oligoribonucleotides containing a few 1-(2-deoxy-2-α-C-hydroxymethyl-β-d-ribofuranosyl)thymine units (or 2′-hm-dT, abbreviated in this work as ‘H’). Both the 2′-CH2O-phosphoramidite and 3′-O-phosphoram
Autor:
Chang Geng, Peng, Masad J, Damha
Publikováno v:
Nucleic Acids Research
We report the first investigation of oligoribonucleotides containing a few 1-(2-deoxy-2-alpha-C-hydroxymethyl-beta-D-ribofuranosyl)thymine units (or 2'-hm-dT, abbreviated in this work as 'H'). Both the 2'-CH2O-phosphoramidite and 3'-O-phosphoramidite
Akademický článek
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Autor:
Yamada, Takeshi, Chang Geng Peng, Matsuda, Shigeo, Addepalli, Haripriya, Jayaprakash, K. Narayanannair, Alam, Md. Rowshon, Mills, Kathy, Maier, Martin A., Charisse, Klaus, Sekine, Mitsuo, Manoharan, Muthiah, Rajeev, Kallanthottathil G.
Publikováno v:
Journal of Organic Chemistry; 3/4/2011, Vol. 76 Issue 5, p1198-1211, 14p
Autor:
Rajeev, Kallanthottathil G., Jayaprakash, K. Narayanannair, Gang Wang, Zhang, Ligang, Chang Geng Peng, Sherman, Jennifer, Chan, Amy, Charisse, Klaus, Kuchimanchi, Satya, Hutabarat, Renta, Maier, Martin, Zimmermann, Tracy S., Fitzgerald, Kevin, Manoharan, Muthiah
Publikováno v:
Nucleic Acid Therapeutics; Dec2012, Vol. 22 Issue 6, pA-6-A-7, 2p