Base editing-coupled survival screening enabled high-sensitive analysis of PAM compatibility and finding of the new possible off-target

Autor: Su, Tianyuan, Guo, Qi, Zheng, Yi, Chang, Yizhao, Gu, Fei, Lu, Xuemei, Qi, Qingsheng

Publikováno v: In iScience 23 July 2021 24(7)

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Mapping of Nonhomologous End Joining-Mediated Integration Facilitates Genome-Scale Trackable Mutagenesis in Yarrowia lipolytica .

Autor: Liu X; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China., Liu M; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China., Zhang J; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China., Chang Y; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China., Cui Z; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China., Ji B; Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden., Nielsen J; Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden.; BioInnovation Institute, 2200 Copenhagen N, Denmark., Qi Q; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China., Hou J; State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.

Publikováno v: ACS synthetic biology [ACS Synth Biol] 2022 Jan 21; Vol. 11 (1), pp. 216-227. Date of Electronic Publication: 2021 Dec 27.