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The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain.

Autor: Higginson LA, Wang X, He K, Torstrick M, Kim M, Benayoun BA, MacLean A, Chanfreau GF, Morton DJ

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30.

Nonfunctional coq10 mutants maintain the ERMES complex and reveal true phenotypes associated with the loss of the coenzyme Q chaperone protein Coq10.

Autor: Novales NA; Department of Chemistry & Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA., Feustel KJ; Department of Chemistry & Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA., He KL; Department of Chemistry & Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA., Chanfreau GF; Department of Chemistry & Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA., Clarke CF; Department of Chemistry & Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California, USA. Electronic address: cathy@chem.ucla.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Sep 27; Vol. 300 (11), pp. 107820. Date of Electronic Publication: 2024 Sep 27.

Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol.

Autor: Krieger MR; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., Abrahamian M; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., He KL; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., Atamdede S; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., Hakimjavadi H; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA, USA., Momcilovic M; Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA., Ostrow D; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA, USA., Maggo SD; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA, USA., Tsang YP; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA., Gai X; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chanfreau GF; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, UCLA, Los Angeles, CA, USA., Shackelford DB; Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA., Teitell MA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, UCLA, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, USA.; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA.; NanoSystems Institute, UCLA, Los Angeles, CA, USA., Koehler CM; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA koehlerc@chem.ucla.edu.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Molecular Biology Institute, UCLA, Los Angeles, CA, USA.

Publikováno v: Life science alliance [Life Sci Alliance] 2024 Jul 02; Vol. 7 (9). Date of Electronic Publication: 2024 Jul 02 (Print Publication: 2024).

Splicing factor Prp18p promotes genome-wide fidelity of consensus 3'-splice sites.

Autor: Roy KR; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Gabunilas J; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA., Neutel D; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA., Ai M; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA., Yeh Z; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA., Samson J; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA., Lyu G; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA., Chanfreau GF; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Dec 11; Vol. 51 (22), pp. 12428-12442.