Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Chanele K. Polenz"'
Autor:
Kenneth K. Y. Ting, Pei Yu, Riley Dow, Hisham Ibrahim, Saraf Karim, Chanele K. Polenz, Daniel A. Winer, Minna Woo, Jenny Jongstra-Bilen, Myron I. Cybulsky
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis. Yet, how lipid loading modulates Mφ inflammatory responses remains unclear. We endeavored to gain mechanistic insights into how pre-loading with free cholesterol mod
Externí odkaz:
https://doaj.org/article/911cea6d5d134c2c8c4a5e9662c77c10
Autor:
Corey A Scipione, Sharon J Hyduk, Chanele K Polenz, Marwan G Althagafi, Hisham M Ibrahim, Sonya A MacParland, Myron I Cybulsky
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Hypercholesterolemia (HC) is a key risk factor of atherosclerosis, a chronic inflammatory disease that causes myocardial infarction and stroke. Although all regions of arteries are exposed to HC, atherosclerosis develops in discrete regions, such as
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
CD11c + myeloid cells (MCs) reside in the normal aortic arch intima at regions predisposed to atherosclerosis. We showed that reverse transendothelial migration (RTM) of these intimal MCs into the arterial circulation is a protective immune response.
Autor:
Corey A. Scipione, Jenny Jongstra-Bilen, Jiro Ikeda, Allan Siu, Marwan G. Althagafi, Chanele K. Polenz, Sharon J. Hyduk, Saraf Karim, Kelly Tai, Myron I. Cybulsky
Publikováno v:
Journal of molecular and cellular cardiology. 156
One of the hallmarks of atherosclerosis is ongoing accumulation of macrophages in the artery intima beginning at disease onset. Monocyte recruitment contributes to increasing macrophage abundance at early stages of atherosclerosis. Although the chemo