Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Chandy C, John"'
Autor:
Adnan Gopinadhan, Jason M. Hughes, Andrea L. Conroy, Chandy C. John, Scott G. Canfield, Dibyadyuti Datta
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Blood–brain barrier (BBB) disruption is a central feature of cerebral malaria (CM), a severe complication of Plasmodium falciparum (Pf) infections. In CM, sequestration of Pf-infected red blood cells (Pf-iRBCs) to brain endothel
Externí odkaz:
https://doaj.org/article/7d673f06ff7e46ea816437b94c0968fb
Autor:
Rabindra K. Mandal, Anita Mandal, Joshua E. Denny, Ruth Namazii, Chandy C. John, Nathan W. Schmidt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Malaria is caused by Plasmodium species and remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of specific bacteria to the risk of severe malaria is unkno
Externí odkaz:
https://doaj.org/article/dc7dea94af4e4493b570a442683cb086
Autor:
Kamija S Phiri, ProfMD PhD, Carole Khairallah, MSc, Titus K Kwambai, MD PhD, Kalifa Bojang, MD PhD, Aggrey Dhabangi, MD PhD, Robert Opoka, MD PhD, Richard Idro, MD PhD, Kasia Stepniewska, PhD, Michael Boele van Hensbroek, ProfPhD, Chandy C John, ProfPhD, Bjarne Robberstad, ProfPhD, Brian Greenwood, ProfMD, Feiko O ter Kuile, ProfMD PhD
Publikováno v:
The Lancet Global Health, Vol 12, Iss 1, Pp e33-e44 (2024)
Summary: Background: Severe anaemia is associated with high in-hospital mortality among young children. In malaria-endemic areas, surviving children also have an increased risk of mortality or readmission after hospital discharge. We conducted a syst
Externí odkaz:
https://doaj.org/article/39c3c2661e774079a10a953b77bd73e5
Autor:
Marilyn Vasquez, Margaux Sica, Ruth Namazzi, Robert O. Opoka, Julian Sherman, Dibyadyuti Datta, Miquel Duran-Frigola, John M. Ssenkusu, Chandy C. John, Andrea L. Conroy, Ana Rodriguez
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since dyserythropoiesis, hemolysis and phagocytic clearance of uninfected red blood cells (RBCs) can
Externí odkaz:
https://doaj.org/article/5ed8c2d832a1418dab36fdd9cf6922fa
Autor:
Andrew Sentoogo Ssemata, Ann Jacquelline Nakitende, Simon Kizito, Melissa R. Thomas, Sumaiya Islam, Paul Bangirana, Noeline Nakasujja, Ziyi Yang, Yunpeng Yu, Tuan M. Tran, Chandy C. John, Megan S. McHenry
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Malaria affects 24 million children globally, resulting in nearly 500,000 child deaths annually in low- and middle-income countries (LMICs). Recent studies have provided evidence that severe malaria infection results in sustained
Externí odkaz:
https://doaj.org/article/e255ec6addc34dd0b5e0b43aae1591da
Autor:
Lindsey B. Turnbull, George Ayodo, Veronicah Knight, Chandy C. John, Megan S. McHenry, Tuan M. Tran
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Accurate detection of asymptomatic malaria parasitaemia in children living in high transmission areas is important for malaria control and reduction programmes that employ screen-and-treat surveillance strategies. Relative to micr
Externí odkaz:
https://doaj.org/article/04adeefe8dd244cab1893546f3be9ba3
Autor:
Andrea L. Conroy, Michael T. Hawkes, Aleksandra Leligdowicz, Ivan Mufumba, Michelle C. Starr, Kathleen Zhong, Sophie Namasopo, Chandy C. John, Robert O. Opoka, Kevin C. Kain
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa. The pathogenesis and prognostic significance of BWF and AKI are not well understood. Method
Externí odkaz:
https://doaj.org/article/244789fa171d48228629f018b9ea14c8
Autor:
Andrea L. Conroy, Dibyadyuti Datta, Robert O. Opoka, Anthony Batte, Paul Bangirana, Adnan Gopinadhan, Kagan A. Mellencamp, Ayse Akcan-Arikan, Richard Idro, Chandy C. John
Publikováno v:
Frontiers in Human Neuroscience, Vol 17 (2023)
IntroductionCerebral malaria is one of the most severe manifestations of malaria and is a leading cause of acquired neurodisability in African children. Recent studies suggest acute kidney injury (AKI) is a risk factor for brain injury in cerebral ma
Externí odkaz:
https://doaj.org/article/cd473cf8e6004ed1801cdcad22cecdb6
Autor:
Anthony Batte, Philip Kasirye, Reagan Baluku, Sarah Kiguli, Robert Kalyesubula, Chandy C. John, Andrew L. Schwaderer, Erik A. Imel, Andrea L. Conroy
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2023)
BackgroundMineral bone disorders (MBD) are common in sickle cell anemia (SCA). Frequent vaso-occlusive crises (VOC) further impact MBD in children with SCA. We evaluated the prevalence of markers of SCA-related MBD (sMBD) in hospitalized children and
Externí odkaz:
https://doaj.org/article/43d0fa61b789443a999bc2479b135438
Autor:
Anthony Batte, Sahit Menon, John Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Edrisa Ibrahim Mutebi, Robert O. Opoka, Chandy C. John, Michelle C. Starr, Andrea L. Conroy
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Children with sickle cell anemia (SCA) are at increased risk of acute kidney injury (AKI) that may lead to death or chronic kidney disease. This study evaluated AKI prevalence and risk factors in children with SCA hospitalized wit
Externí odkaz:
https://doaj.org/article/47a2dc5ff9044a478dcb272222300282