Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Chandrika B-Rao"'
Autor:
Smriti Khanna, Chandrika B-Rao, Kishori Sharan Singh, Abhijit Roychowdhury, Julie Bose, Rajiv Sharma, Sambhaji V. Patil, Anagha Damre, Neeta Dixit, Sambhaji Chavan, Valmik Sopan Aware, Sonal M Manohar, Nitin D. Gaikwad
Publikováno v:
European Journal of Medicinal Chemistry. 92:246-256
A series of novel 2-amino-4-pyrazolecyclopentylpyrimidines have been prepared and evaluated as IGF-1R tyrosin kinase inhibitors. The in vitro activity was found to depend strongly on the substitution pattern in the 2- amino ring, 4-pyrazolo moieties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e547da4c9b314e411900c9aa17d95322
https://doi.org/10.1016/j.ejmech.2014.12.053
https://doi.org/10.1016/j.ejmech.2014.12.053
Autor:
Nabajyoti Deka, Swapnil Bajare, Anagha Damre, Amrutha Nair, Dharmeshkumar Patel, Rosalind Adaikalasamy Marita, H. Sivaramakrishnan, Jessy Anthony, Chandan Wilankar, Chandrika B-Rao, Shivaprakash Jagalur Mutt
Publikováno v:
International Journal of Medicinal Chemistry
International Journal of Medicinal Chemistry, Vol 2013 (2013)
International Journal of Medicinal Chemistry, Vol 2013 (2013)
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252b32d8fb4cc8b994dc91eab0b42aed
https://doi.org/10.1155/2013/201580
https://doi.org/10.1155/2013/201580
Autor:
H. Sivaramakrishnan, Sujit Kaur Bhumra, Dharmeshkumar Patel, Amrutha Nair, Jessy Anthony, Chandrika B-Rao, Nabajyoti Deka, Mahesh Uravane
Publikováno v:
Medicinal Chemistry Research. 23:2150-2159
Thiazolidinediones (TZDs) are an important class of compound used for the treatment of type 2 diabetes, targeting the peroxisome proliferator-activated receptor γ (PPARγ). Drug-induced hepatotoxicity, edema, and weight gain are the main concerns as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980b6b689f7cfecc7253db60f9e148e7
https://doi.org/10.1007/s00044-013-0814-y
https://doi.org/10.1007/s00044-013-0814-y
Autor:
Usha Ghosh, Smriti Khanna, Asha Kulkarni-Almeida, Ankita Srivastava, Komal Bajaj, Chandrika B-Rao, Prashant Tannu, Ashish P. Keche, Kumar V.S. Nemmani, Pranay Shah, Sandeep Burudkar, Rajiv Sharma, Yogesh Suresh Ahire, H. Sivaramakrishnan, Amol Dixit, Anagha Damre, Nitin J. Deshmukh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:834-838
We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good in vivo efficacy when administered intraperitoneall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866072cdc89ac5f3a8aa3b0daba5e338
https://doi.org/10.1016/j.bmcl.2012.11.057
https://doi.org/10.1016/j.bmcl.2012.11.057
Autor:
Rajiv Sharma, Smriti Khanna, Umakant Ashok Bahirat, Asha Kulkarni-Almeida, Pranay Shah, Amol Dixit, Kamlesh V. Katkar, Kumar V.S. Nemmani, Ashish P. Keche, H. Sivaramakrishnan, Vaidehi Korde, Chandrika B-Rao, Ankita Srivastava, Nitin J. Deshmukh, Manoja K. Brahma, Lalit S. Doshi, Usha Ghosh
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2930-2939
In recent years, xanthine oxidase has emerged as an important target not only for gout but also for cardiovascular and metabolic disorders involving hyperuricemia. Contrary to popular belief, recent clinical trials with uricosurics have demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f36cd3ab923720ed9f3033ad523d3d5
https://doi.org/10.1016/j.bmc.2012.03.019
https://doi.org/10.1016/j.bmc.2012.03.019
Publikováno v:
Drug Discovery Today. 14:394-400
Docking, virtual screening and structure-based drug design are routinely used in modern drug discovery programs. Although current docking methods deal with flexible ligands, managing receptor flexibility has proved to be challenging. In this brief re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef91ed4cc8f5eb44bc8c2f5787e73b6
https://doi.org/10.1016/j.drudis.2009.01.003
https://doi.org/10.1016/j.drudis.2009.01.003
Publikováno v:
ChemMedChem. 3:336-344
Receptor rearrangement upon ligand binding (induced fit) is a major stumbling block in docking and virtual screening. Even though numerous studies have stressed the importance of including protein flexibility in ligand docking, currently available me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0999f32424b02dc601bec0bd9f8d38
https://doi.org/10.1002/cmdc.200700255
https://doi.org/10.1002/cmdc.200700255
Autor:
Simone Gupta, Randeep Guleria, Pallav Bhatnagar, Samir K. Brahmachari, Balaram Ghosh, Chinmoyee Das, Babita Madan, Ritushree Kukreti, Amita Umesh Athavale, Chandrika B-Rao
Publikováno v:
Pharmacogenomics. 6:399-410
Introduction: The β2-adrenergic receptor (β2AR or ADRβ2) is the target for β2-agonist drugs used for bronchodilation in asthma and other respiratory diseases. The aim of this study was to identify common single nucleotide polymorphisms (SNPs) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c50349e1d94fa39df84ef250fd57d4
https://doi.org/10.1517/14622416.6.4.399
https://doi.org/10.1517/14622416.6.4.399
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 31:317-321
In this paper, we report for the first time the results of an investigation on the association of signal transducer and activator of transcription 6 (STAT6) with asthma in the Indian population. A novel polymorphic CA-repeat in the proximal promoter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee24634fd13eac53fddaa108b90eafe8
https://doi.org/10.1165/rcmb.2003-0128oc
https://doi.org/10.1165/rcmb.2003-0128oc
Publikováno v:
Molecular Biology and Evolution. 20:1420-1424
The first draft of the human genome has revealed enormous variability in the global distribution of Alu repeat elements. There are regions such as the four homeobox gene clusters, which are nearly devoid of these repeats that contrast with repeat den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec3169c4e91f3427ff6c585b0ada7b9
https://doi.org/10.1093/molbev/msg153
https://doi.org/10.1093/molbev/msg153