Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding.

Autor: Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Roules GC; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Jagadeesan N; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Panchal UR; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Oyegbesan A; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Imiruaye OE; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States., Zhang H; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, United States., Garcia J; Department of Biology, University of La Verne, La Verne, CA, United States., Kaur K; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Win S; Department of Medicine, Division of Gastroenterology and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Than TA; Department of Medicine, Division of Gastroenterology and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Kaplowitz N; Department of Medicine, Division of Gastroenterology and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Roosan MR; Pharmacy Practice, School of Pharmacy, Chapman University, Irvine, CA, United States., Han D; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States. Electronic address: dhan@kgi.edu., Sumbria RK; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States; Department of Neurology, University of California, Irvine, CA, United States. Electronic address: sumbria@chapman.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2024 Sep; Vol. 199, pp. 106570. Date of Electronic Publication: 2024 Jun 15.

Development and validation of an ultrahigh-performance liquid chromatography-tandem mass spectrometry method to investigate the plasma pharmacokinetics of a K Ca 2.2/K Ca 2.3 positive allosteric modulator in mice.

Autor: Rahman MA; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Nam YW; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Syed B; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Salehi D; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Aliabadi HM; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Zhang M; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Mehvar R; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA.

Publikováno v: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2023 Aug 15; Vol. 37 (15), pp. e9537.

Generation and Characterization of CYP2E1-Overexpressing HepG2 Cells to Study the Role of CYP2E1 in Hepatic Hypoxia-Reoxygenation Injury.

Autor: Alwadei N; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA., Rashid M; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA., Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA., Rahighi S; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA., Totonchy J; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA., Sharma A; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA., Mehvar R; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 May 01; Vol. 24 (9). Date of Electronic Publication: 2023 May 01.

Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis-Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes.

Autor: Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., DuBois BN; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Rashid M; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Mehvar R; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA.

Publikováno v: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2023 Feb; Vol. 132 (2), pp. 197-210. Date of Electronic Publication: 2022 Nov 24.

Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β.

Autor: Garcia J; Department of Biology, University of La Verne, Verne, CA, United States., Chang R; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Steinberg RA; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States., Arce A; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States., Yang J; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Van Der Eb P; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States., Abdullah T; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States., Eck SM; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States., Meza P; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States., Liu ZX; Department of Molecular Microbiology and Immunology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Cadenas E; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, United States., Cribbs DH; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States., Kaplowitz N; University of Southern California Research Center for Liver Diseases and Southern California Research Center for ALPD, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Sumbria RK; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States.; Department of Neurology, University of California, Irvine, Irvine, CA, United States., Han D; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, United States.

Publikováno v: Frontiers in physiology [Front Physiol] 2022 Sep 15; Vol. 13, pp. 930402. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).