The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

Autor: Oliver H. Wearing, Catherine M. Ivy, Natalia Gutiérrez-Pinto, Jonathan P. Velotta, Shane C. Campbell-Staton, Chandrasekhar Natarajan, Zachary A. Cheviron, Jay F. Storz, Graham R. Scott

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)

Abstract Background Complex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions shape the evolutionary trajectories of adaptive traits is poorly understood. We examined how fu

Externí odkaz: https://doaj.org/article/fbe09799084040bdac218fcb486a398c

Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin

Autor: Chandrasekhar Natarajan, Anthony V. Signore, Naim M. Bautista, Federico G. Hoffmann, Jeremy R. H. Tame, Angela Fago, Jay F. Storz

Publikováno v: Natarajan, C, Signore, A V, M. Bautista, N, Hoffmann, F G, Tame, J R H, Fago, A & Storz, J F 2023, ' Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin ', Current Biology, vol. 33, no. 1, pp. 98-108.e4 . https://doi.org/10.1016/j.cub.2022.11.049

Understanding the evolution of novel protein functions requires data on the mechanistic effects of causative mutations and the extent of coupling between the gain of new function and loss of ancestral function. Here, we use ancestral protein resurrec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1137392177294b0741819d8588aa5da0
https://pure.au.dk/portal/da/publications/evolution-and-molecular-basis-of-a-novel-allosteric-property-of-crocodilian-hemoglobin(ee444a43-d9e4-426b-a175-7e890e1b1673).html

Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice.

Autor: Noriko Inoguchi, Nobuhiro Mizuno, Seiki Baba, Takashi Kumasaka, Chandrasekhar Natarajan, Jay F Storz, Hideaki Moriyama

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174921 (2017)

BACKGROUND:Deer mice (Peromyscus maniculatus) that are native to high altitudes in the Rocky Mountains have evolved hemoglobins with an increased oxygen-binding affinity relative to those of lowland conspecifics. To elucidate the molecular mechanisms

Externí odkaz: https://doaj.org/article/ddcbca32f25844b3a2789a4c6a2341e3

Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice

Autor: Catherine M. Ivy, Oliver H. Wearing, Chandrasekhar Natarajan, Rena M. Schweizer, Natalia Gutiérrez-Pinto, Jonathan P. Velotta, Shane C. Campbell-Staton, Elin E. Petersen, Angela Fago, Zachary A. Cheviron, Jay F. Storz, Graham R. Scott

Publikováno v: J Exp Biol
Ivy, C M, Wearing, O H, Natarajan, C, Schweizer, R M, Gutiérrez-Pinto, N, Velotta, J P, Campbell-Staton, S C, Petersen, E E, Fago, A, Cheviron, Z A, Storz, J F & Scott, G R 2022, ' Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice ', Journal of Experimental Biology, vol. 225, no. 2, jeb243595 . https://doi.org/10.1242/jeb.243595

Physiological systems often have emergent properties but the effects of genetic variation on physiology are often unknown, which presents a major challenge to understanding the mechanisms of phenotypic evolution. We investigated whether genetic varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7af77811ea1d7d03653bb70dd24972
https://doi.org/10.1242/jeb.243595

The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

Autor: Zachary A. Cheviron, Oliver H. Wearing, Jay F. Storz, Catherine M. Ivy, Chandrasekhar Natarajan, Natalia Gutiérrez-Pinto, Jonathan P. Velotta, Graham R. Scott, Shane C. Campbell-Staton

Publikováno v: BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)

BackgroundComplex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions shape the evolutionary trajectories of adaptive traits is poorly understood. We examined how functional i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ced6bc9b335175ca6ca1fdb2ba7650
https://doi.org/10.1186/s12915-021-01059-4