Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

Autor: Wei, Jingyi, Lotfy, Peter, Faizi, Kian, Baungaard, Sara, Gibson, Emily, Wang, Eleanor, Slabodkin, Hannah, Kinnaman, Emily, Chandrasekaran, Sita, Kitano, Hugo, Durrant, Matthew G., Duffy, Connor V., Pawluk, April, Hsu, Patrick D., Konermann, Silvana

Publikováno v: In Cell Systems 20 December 2023 14(12):1087-1102

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Rapid detection of SARS-CoV-2 with Cas13

Autor: Agrawal, Shreeya, Fanton, Alison, Chandrasekaran, Sita S., Prywes, Noam, Lukarska, Maria, Biering, Scott B., Smock, Dylan C. J., Mok, Amanda, Knott, Gavin J., Van Dis, Erik, Dugan, Eli, Kim, Shin, Liu, Tina Y., Harris, Eva, Stanley, Sarah A., Lareau, Liana F., Doudna, Jennifer A., Savage, David F., Hsu, Patrick D.

Publikováno v: medRxiv
article-version (status) pre
article-version (number) 1

Rapid nucleic acid testing is a critical component of a robust infrastructure for increased disease surveillance. Here, we report a microfluidic platform for point-of-care, CRISPR-based molecular diagnostics. We first developed a nucleic acid test wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::759f0576b19345e4bd3e13735a765162
http://europepmc.org/articles/PMC7755151

Microviscosity in E. coliCells from Time-Resolved Linear Dichroism Measurements

Autor: Chen, Eefei, Esquerra, Raymond M., Meléndez, Philipp A., Chandrasekaran, Sita S., Kliger, David S.

Publikováno v: The Journal of Physical Chemistry - Part B; July 2018, Vol. 122 Issue: 49 p11381-11389, 9p

Rapid, point-of-care molecular diagnostics with Cas13.

Autor: Agrawal S; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Fanton A; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA., Chandrasekaran SS; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA., Charrez B; University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA., Escajeda AM; Wainamics Inc., Pleasanton, CA, USA., Son S; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Mcintosh R; Wainamics Inc., Pleasanton, CA, USA., Bhuiya A; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA., de León Derby MD; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA., Switz NA; Department of Physics and Astronomy, San José State University, San José, CA, USA., Armstrong M; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Harris AR; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Prywes N; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Lukarska M; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Smock DCJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Mok A; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Knott GJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia., Dang Q; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Van Dis E; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Dugan E; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Kim S; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Liu TY; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Stanley SA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; School of Public Health, University of California, Berkeley, CA, USA., Lareau LF; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Tan MX; Wainamics Inc., Pleasanton, CA, USA., Fletcher DA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Doudna JA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Hsu PD; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2021 Apr 05. Date of Electronic Publication: 2021 Apr 05.