Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses.

Autor: Thangavelu G; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Wang C; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA., Loschi M; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Saha A; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Osborn MJ; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Furlan SN; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, University of Washington, Seattle, WA., Aoyama K; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., McDonald-Hyman C; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Aguilar EG; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Janesick AS; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA., Chandraratna RA; Io Therapeutics, Santa Ana, CA., Refaeli Y; Department of Dermatology, University of Colorado, Aurora, CO., Panoskaltsis-Mortari A; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., MacDonald KP; Department of Immunology, Queensland Institute of Medical Research (QIMR), University of Queensland, Brisbane, QLD, Australia., Hill GR; Clinical Research Division and.; Division of Medical Oncology, Fred Hutchinson Cancer Research Center, Seattle, WA., Zeiser R; Department of Internal Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Maillard I; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA., Serody JS; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC., Murphy WJ; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA., Munn DH; Georgia Cancer Center, Augusta University, Augusta, GA., Blumberg B; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA., Brown C; Division of Transplantation Immunology and Mucosal Biology, King's College London, London, United Kingdom., Kuchroo V; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA., Kean LS; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA; and., Hippen KL; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN., Noelle RJ; Department of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, NH., Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN.

Publikováno v: Blood [Blood] 2021 Feb 25; Vol. 137 (8), pp. 1090-1103.

The retinoid X receptor has a critical role in synthetic rexinoid-induced increase in cellular all-trans-retinoic acid.

Autor: Belyaeva, Olga V.¹ (AUTHOR), Klyuyeva, Alla V.¹ (AUTHOR), Vyas, Ansh¹ (AUTHOR), Berger, Wilhelm K.² (AUTHOR), Halasz, Laszlo² (AUTHOR), Yu, Jianshi³ (AUTHOR), Atigadda, Venkatram R.⁴ (AUTHOR), Slay, Aja¹ (AUTHOR), Goggans, Kelli R.¹ (AUTHOR), Renfrow, Matthew B.¹ (AUTHOR), Kane, Maureen A.³ (AUTHOR), Nagy, Laszlo² (AUTHOR), Kedishvili, Natalia Y.¹ (AUTHOR) nkedishvili@uab.edu

Publikováno v: PLoS ONE. 4/1/2024, Vol. 19 Issue 4, p1-20. 20p.

IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors.

Autor: Alessio, Nicola¹ (AUTHOR), Aprile, Domenico¹ (AUTHOR), Peluso, Gianfranco² (AUTHOR), Mazzone, Valeria¹ (AUTHOR), Patrone, Deanira¹ (AUTHOR), Di Bernardo, Giovanni¹ (AUTHOR) umberto.galderisi@unicampania.it, Galderisi, Umberto^1,3,4 (AUTHOR) gianni.dibernardo@unicampania.it

Publikováno v: Cell Communication & Signaling. 2/13/2024, Vol. 22 Issue 1, p1-17. 17p.

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Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease.

Autor: Wang J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Geriatric Research, Education and Clinical Center, Bronx, NY, USA., Bi W; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhao W; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Varghese M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Koch RJ; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA., Walker RH; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA., Chandraratna RA; Io Therapeutics Inc., Santa Ana, CA, USA., Sanders ME; Io Therapeutics Inc., Santa Ana, CA, USA., Janesick A; Departments of Developmental and Cell Biology, and Pharmaceutical Sciences, University of California, Irvine, CA, USA., Blumberg B; Departments of Developmental and Cell Biology, and Pharmaceutical Sciences, University of California, Irvine, CA, USA., Ward L; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ho L; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pasinetti GM; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Geriatric Research, Education and Clinical Center, Bronx, NY, USA.

Publikováno v: Oncotarget [Oncotarget] 2016 Feb 16; Vol. 7 (7), pp. 7469-79.