Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chandramouli, Chillakuri"'
Autor:
Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering
Externí odkaz:
https://doaj.org/article/d2f84672e7fe4eb3b7df368784cf9d36
Autor:
David Cole, Annelise Vuidepot, Andrew Whale, Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar Haidar, Sylvie Moureau, Aimee Bence Lin, Marc Van der Kamp, Gregory Plowman, Chandramouli Chillakuri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/f88c19af0c8e4b699fedf005b648101c
Supplementary Figures 1-8 from Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy
Autor:
Alison H. Banham, Adrian L. Harris, Penny A. Handford, Nicola R. Sibson, James Larkin, Manuel Sarmiento-Soto, Sébastien Serres, Devon Sheppard, Chandramouli Chillakuri, Ji-Liang Li, Ellen Bealing, Jenna Yates, Stephen Stribbling, Sarah Watts, Tasneem Hassanali, Jenny Greig, Carol Bentley, Pat Whiteman, Demin Li, Massimo Masiero
1: JAG1 antibody characterization. 2: antibody inhibition of JAG1 mediated Notch signalling in tumor cell lines. 3: antibody inhibition of JAG1 signalling in vascular cells. 4: antibody inhibition of JAG1 signalling in HUVEC-HUVSMC co-culture. 5: eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d318461372ffb99d014884e8a0f6cac2
https://doi.org/10.1158/1535-7163.22510647
https://doi.org/10.1158/1535-7163.22510647
Autor:
Alison H. Banham, Adrian L. Harris, Penny A. Handford, Nicola R. Sibson, James Larkin, Manuel Sarmiento-Soto, Sébastien Serres, Devon Sheppard, Chandramouli Chillakuri, Ji-Liang Li, Ellen Bealing, Jenna Yates, Stephen Stribbling, Sarah Watts, Tasneem Hassanali, Jenny Greig, Carol Bentley, Pat Whiteman, Demin Li, Massimo Masiero
Supplementary material and methods. Supplementary table 1: cell lines and growth conditions. Supplementary table 2: Notch ligands and control protein for plate coating. Supplementary table 3: qPCR primers. Supplementary table 4: flow cytometry antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7722864810fcbbbc5d915df61ec1c5
https://doi.org/10.1158/1535-7163.22510644
https://doi.org/10.1158/1535-7163.22510644
Autor:
Alison H. Banham, Adrian L. Harris, Penny A. Handford, Nicola R. Sibson, James Larkin, Manuel Sarmiento-Soto, Sébastien Serres, Devon Sheppard, Chandramouli Chillakuri, Ji-Liang Li, Ellen Bealing, Jenna Yates, Stephen Stribbling, Sarah Watts, Tasneem Hassanali, Jenny Greig, Carol Bentley, Pat Whiteman, Demin Li, Massimo Masiero
The role of Notch signaling and its ligand JAGGED1 (JAG1) in tumor biology has been firmly established, making them appealing therapeutic targets for cancer treatment. Here, we report the development and characterization of human/rat-specific JAG1-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4eef16695f97e97c7b4771d67bccc53
https://doi.org/10.1158/1535-7163.c.6539670
https://doi.org/10.1158/1535-7163.c.6539670
Autor:
Andrew, Poole, Vijaykumar, Karuppiah, Annabelle, Hartt, Jaafar N, Haidar, Sylvie, Moureau, Tomasz, Dobrzycki, Conor, Hayes, Christopher, Rowley, Jorge, Dias, Stephen, Harper, Keir, Barnbrook, Miriam, Hock, Charlotte, Coles, Wei, Yang, Milos, Aleksic, Aimee Bence, Lin, Ross, Robinson, Joe D, Dukes, Nathaniel, Liddy, Marc, Van der Kamp, Gregory D, Plowman, Annelise, Vuidepot, David K, Cole, Andrew D, Whale, Chandramouli, Chillakuri
Publikováno v:
Nature communications. 13(1)
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and d
Autor:
Annabelle Hartt, Andrew Whale, Jaafar N. Haidar, Gregory D. Plowman, Aimee Bence Lin, Andrew Poole, Marc W. van der Kamp, Annelise Vuidepot, Vijaykumar Karuppiah, David K. Cole, Sylvie Moureau, Chandramouli Chillakuri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundKRAS is the most frequently mutated oncogene, yet mutant KRAS has historically been a challenging target for conventional small molecule drug development. Tumour specific neoantigen peptides derived from KRAS are presented by cell surface h
Autor:
Stephen M. Stribbling, Devon Sheppard, Demin Li, Penny A. Handford, P. Whiteman, Tasneem Hassanali, J Greig, M Sarmiento-Soto, J Yates, Nicola R. Sibson, C Bentley, Adrian L. Harris, Sébastien Serres, E Bealing, Alison H. Banham, Li J-L., Massimo Masiero, Chandramouli Chillakuri, Sarah K. Watts, James R. Larkin
Publikováno v:
Mol Cancer Ther
The role of Notch signaling and its ligand JAGGED1 (JAG1) in tumor biology has been firmly established, making them appealing therapeutic targets for cancer treatment. Here, we report the development and characterization of human/rat-specific JAG1-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e075145f2fb6c29e892f5e4581c90865
https://europepmc.org/articles/PMC7611158/
https://europepmc.org/articles/PMC7611158/
Autor:
Pat Whiteman, Boguslawa Korona, Chandramouli Chillakuri, Laurie Holt, Richard Suckling, P.A. Handford, Susan M. Lea
Recent data have expanded our understanding of Notch signaling by identifying a C2 domain at the N-terminus of Notch ligands which has both lipid- and receptor-binding properties. We present novel structures of human ligands Jagged2 and DLL4 and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6c66638c0b9f74206e48ee31d1680e
https://ora.ox.ac.uk/objects/uuid:749c7405-1604-4334-8b18-eb21b79006ee
https://ora.ox.ac.uk/objects/uuid:749c7405-1604-4334-8b18-eb21b79006ee
Autor:
Raphael Kopan, Shaoyan Liang, Susan M. Lea, Felicity Abbott, Laurie Holt, Devon Sheppard, Chandramouli Chillakuri, Ma. Xenia G. Ilagan, Penny A. Handford
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 861-867 (2013)
Cell Reports
Cell Reports
Summary The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. Signals are initiated by extracellular interactions of