Zobrazeno 1 - 10
of 387
pro vyhledávání: '"Chandra Verma"'
Autor:
Jia Wei Siau, Asim Azhar Siddiqui, Sze Yi Lau, Srinivasaraghavan Kannan, Sabrina Peter, Yingying Zeng, Chandra Verma, Peter Droge, John F. Ghadessy
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a8102e41f4cd4c198dc89e84d4769ffd
Autor:
Marcus Gainer, Assen Roguev, Michelle Hung, Rebecca Cottman, Yin Yin Chong, Russell M Gordley, Mark Tomishima, Monika Avina, Timothy K Lu, Vanessa Johnson, Eren Chu, Joseph Sperling, Brett Kiedaisch, Raghav Kannan, Chandra Verma, Chew-Li Soh, Conor McAuliffe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e5f99ced4a4d4c5abf261126cd6fc652
Autor:
Srinivasaraghavan Kannan, Mohan R. Pradhan, Garima Tiwari, Wei-Chong Tan, Balram Chowbay, Eng Huat Tan, Daniel Shao-Weng Tan, Chandra Verma
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Small molecules targeting the EGFR tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced AT
Externí odkaz:
https://doaj.org/article/145a6170f8624c79b228e5d534e4ff3b
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178381 (2017)
The Hippo signaling pathway, which is implicated in the regulation of organ size, has emerged as a potential target for the development of cancer therapeutics. YAP, TAZ (transcription co-activators) and TEAD (transcription factor) are the downstream
Externí odkaz:
https://doaj.org/article/8240fbeb6b854d15b4dbf81c2dc2fa97
Autor:
Nikhil Sangith, Kannan Srinivasaraghavan, Indrajit Sahu, Ankita Desai, Spandana Medipally, Arun Kumar Somavarappu, Chandra Verma, Prasanna Venkatraman
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 571-583 (2014)
PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain. Here we report the identification of five novel interacting partners of PSMD9 and provide the first glimpse at the struct
Externí odkaz:
https://doaj.org/article/df48412dfa954855a4859cb65c2de109
Autor:
Sharon Min Qi Chee, Jantana Wongsantichon, Quah Soo Tng, Robert Robinson, Thomas L Joseph, Chandra Verma, David P Lane, Christopher J Brown, Farid J Ghadessy
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104914 (2014)
As key negative regulator of the p53 tumour suppressor, Mdm2 is an attractive therapeutic target. Small molecules such as Nutlin have been developed to antagonise Mdm2, resulting in p53-dependent death of tumour cells. We have recently described a mu
Externí odkaz:
https://doaj.org/article/75e1615ecfa7434bab2588d9679c1fc7
Autor:
Nikhil Sangith, Kannan Srinivasaraghavan, Indrajit Sahu, Ankita Desai, Spandana Medipally, Arun Kumar Somavarappu, Chandra Verma, Prasanna Venkatraman
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 731-732 (2015)
Externí odkaz:
https://doaj.org/article/39e50e4068c24d14862889dc068a65c9
Autor:
Siau Jia Wei, Thomas Joseph, Sharon Chee, Ling Li, Larisa Yurlova, Kourosh Zolghadr, Christopher Brown, David Lane, Chandra Verma, Farid Ghadessy
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81068 (2013)
Pharmacological modulation of p53 activity is an attractive therapeutic strategy in cancers with wild-type p53. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2, a key negative regulator of p53 and blocks its act
Externí odkaz:
https://doaj.org/article/25eb3a99f712477b8d46971a5e4fc205
Autor:
Siau Jia Wei, Thomas Joseph, Adelene Y L Sim, Larisa Yurlova, Kourosh Zolghadr, David Lane, Chandra Verma, Farid Ghadessy
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62564 (2013)
HDM2 binds to the p53 tumour suppressor and targets it for proteosomal degradation. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2 and abrogates its repressive function. Using a novel in vitro selection methodo
Externí odkaz:
https://doaj.org/article/fa65957a36664f88a1240eafe86b86b1
Autor:
Sanjiv Sonkaria, Gloria Fuentes, Chandra Verma, Ram Narang, Varsha Khare, Anna Fischer, Damien Faivre
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e34189 (2012)
Magnetotactic bacteria (MTB) synthesize magnetosomes, which are intracellular vesicles comprising a magnetic particle. A series of magnetosomes arrange themselves in chains to form a magnetic dipole that enables the cell to orient itself along the Ea
Externí odkaz:
https://doaj.org/article/13a47203bb614c1fba3f2882b4aebe47