Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Chandra Sekhar Boddupalli"'
Autor:
Chandra Sekhar Boddupalli, Shiny Nair, Glenn Belinsky, Joseph Gans, Erin Teeple, Tri-Hung Nguyen, Sameet Mehta, Lilu Guo, Martin L Kramer, Jiapeng Ruan, Honggge Wang, Matthew Davison, Dinesh Kumar, DJ Vidyadhara, Bailin Zhang, Katherine Klinger, Pramod K Mistry
Publikováno v:
eLife, Vol 11 (2022)
Background: Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in GBA and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features; however, the
Externí odkaz:
https://doaj.org/article/ae7987b768304a36b201d016d7515a85
Autor:
Shiny Nair, Chandra Sekhar Boddupalli, Glenn Belinsky, Joseph Gans, Erin Teeple, Tri-Hung Nguyen, Sameet Mehta, Lilu Guo, Martin L Kramer, Jiapeng Ruan, Honggge Wang, Matthew Davison, Dinesh Kumar, DJ Vidyadhara, Bailin Zhang, Katherine Klinger, Pramod K Mistry
Publikováno v:
eLife. 11
Background:Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in GBA and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features; however, the
Autor:
Shiny Nair, Chandra Sekhar Boddupalli, Glenn Belinsky, Joseph Gans, Erin Teeple, Tri-Hung Nguyen, Sameet Mehta, Lilu Guo, Martin L Kramer, Jiapeng Ruan, Honggge Wang, Matthew Davison, Dinesh Kumar, DJ Vidyadhara, Bailin Zhang, Katherine Klinger, Pramod K Mistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4dcf1e98085248eb7f4c9793843c075
https://doi.org/10.7554/elife.79830.sa2
https://doi.org/10.7554/elife.79830.sa2
Autor:
Chandra Sekhar Boddupalli, Shiny Nair, Glenn Belinsky, Joseph Gans, Erin Teeple, Tri-Hung Nguyen, Sameet Mehta, Lilu Guo, Martin L Kramer, Jiapeng Ruan, Hongge Wang, Matthew Davison, D.J Vidyadhara, Zhang Bailin, Katherine Klinger, Pramod K. Mistry
BackgroundNeuronopathic Gaucher Disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in Gba, and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features, however the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36693d6f82667faed2cec1974d70d3b1
https://doi.org/10.1101/2022.05.13.491834
https://doi.org/10.1101/2022.05.13.491834
Autor:
Jun Liu, Pramod K. Mistry, Madhav V. Dhodapkar, Shiny Nair, Chandra Sekhar Boddupalli, Andrew R. Branagan
Publikováno v:
New England Journal of Medicine. 374:555-561
Antigen-driven selection has been implicated in the pathogenesis of monoclonal gammopathies. Patients with Gaucher's disease have an increased risk of monoclonal gammopathies. Here we show that the clonal immunoglobulin in patients with Gaucher's dis
Autor:
Jedd D. Wolchok, Margaret K. Callahan, Rakesh Verma, Kavita M. Dhodapkar, Harriet M. Kluger, Chandra Sekhar Boddupalli, Mario Sznol, Rituparna Das, Scott N. Gettinger, Ruth Halaban, Madhav V. Dhodapkar
Publikováno v:
The Journal of Immunology. 194:950-959
Combination therapy concurrently targeting PD-1 and CTLA-4 immune checkpoints leads to remarkable antitumor effects. Although both PD-1 and CTLA-4 dampen the T cell activation, the in vivo effects of these drugs in humans remain to be clearly defined
Autor:
Pramod K. Mistry, Dirk Hose, Madhav V. Dhodapkar, Lin Zhang, Chandra Sekhar Boddupalli, Mariateresa Fulciniti, Richard A. Flavell, Joel Sng, Navin Rauniyar, Marta Chesi, Terri L. Parker, Eric Meffre, Leif Bergsagel, Bart Barlogie, Rachael Sexton, Natalia Neparidze, Nikhil C. Munshi, Robert Z. Orlowski, Shiny Nair, Michael A. Lopez, Anja Seckinger
Publikováno v:
JCI insight. 3(8)
A role for antigen-driven stimulation has been proposed in the pathogenesis of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) based largely on the binding properties of monoclonal Ig. However, insights into antige
Autor:
Noffar Bar, Mario Sznol, Kavita M. Dhodapkar, Zifeng Mai, Ruth Halaban, Harriet M. Kluger, Stephan Ariyan, Michael Krauthammer, Yanhong Deng, Natopol Pornputtapong, Rakesh Verma, Antonella Bacchiocchi, Madhav V. Dhodapkar, Chandra Sekhar Boddupalli, Deepak Narayan, Krishna Kadaveru, Rituparna Das
Heterogeneity of tumor cells and their microenvironment can affect outcome in cancer. Blockade of immune checkpoints (ICPs) expressed only on a subset of immune cells leads to durable responses in advanced melanoma. Tissue-resident memory T (TRM) cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea460d9c94f01e12dcc936355289e00
https://europepmc.org/articles/PMC5161225/
https://europepmc.org/articles/PMC5161225/
Autor:
Terri L. Parker, Madhav V. Dhodapkar, Daniel Zelterman, Dennis L. Cooper, Geliang Gan, Chandra Sekhar Boddupalli, Stuart Seropian, Randy A. Albrecht, Andrew R. Branagan, Rakesh Verma, Fangyong Li, Eamon Duffy, Thomas M. Ferencz, Lin Zhang
Publikováno v:
Clinical lymphoma, myelomaleukemia. 17(5)
Background Patients with multiple myeloma (MM) and other plasma cell disorders are highly susceptible to influenza infections, which are major causes of morbidity in this population, despite the routine administration of a seasonal influenza vaccinat
Publikováno v:
European Journal of Immunology. 43:1651-1658
Lymphoid-tissue dendritic cells (DCs) are short-lived and need to be continuously replenished from bone marrow-derived DC progenitor cells. Fms-related tyrosine kinase 3 is expressed during cellular development from hematopoietic progenitors to lymph