Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells.

Autor: Ajay Palagani, Ken Op de Beeck, Stefan Naulaerts, Jolien Diddens, Chandra Sekhar Chirumamilla, Guy Van Camp, Kris Laukens, Karen Heyninck, Sarah Gerlo, Pieter Mestdagh, Joke Vandesompele, Wim Vanden Berghe

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113842 (2014)

Glucocorticoids (GCs) selectively trigger cell death in the multiple myeloma cell line MM1S which express NR3C1/Glucocorticoid Receptor (GR) protein, but fail to kill MM1R cells which lack GR protein. Given recent demonstrations of altered microRNA p

Externí odkaz: https://doaj.org/article/55383d82c97441059c5917eabd8cfb0e

The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling

Autor: Siu Kwan Sze, Claudina Perez-Novo, Navin Kumar Verma, Wim Vanden Berghe, Chandra Sekhar Chirumamilla, Brandon Han Siang Wong, Mobashar Hussain Urf Turabe Fazil, Sunil Kumar

Publikováno v: The Journal of Biological Chemistry
Journal of biological chemistry

The steroidal lactone withaferin A (WFA) is a dietary phytochemical, derived from Withania somnifera. It exhibits a wide range of biological properties, including immunomodulatory, anti-inflammatory, antistress, and anticancer activities. Here we inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6d3205392f734f50cbfb69dbbe5f0b
https://hdl.handle.net/10356/161091

Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A

Autor: Claudina Perez-Novo, Wim Vanden Berghe, Xaveer Van Ostade, Chandra Sekhar Chirumamilla

Publikováno v: Proceedings of the Nutrition Society

Despite the worldwide research efforts to combat cancer, it remains a leading cause of death. Although various specific kinase inhibitors already have been approved for clinical cancer treatment, occurrence of intrinsic or acquired resistance and int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca130c48477ca5c3cd39acbb19d61be
https://doi.org/10.1017/s0029665116002937

Profiling Activity of Cellular Kinases in Migrating T-Cells

Autor: Wim Vanden Berghe, Claudina Perez-Novo, Chandra Sekhar Chirumamilla, Mobashar Hussain Urf Turabe Fazil, Navin Kumar Verma, Padma Ramireddy, Rik de Wijn, Savithri Rangarajan

Publikováno v: Methods in Molecular Biology ISBN: 9781493990351
Methods in molecular biology

T-Lymphocyte kinases are important checkpoints that control T-cell motility by regulating a diverse range of signal transduction pathways. The distinct configuration of kinase events in T-cell could be used to fingerprint the status of T-cells. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ca56244abb223cd1a3839bfb67c791
https://doi.org/10.1007/978-1-4939-9036-8_13

A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites

Autor: Katarzyna Szarc vel Szic, Laurent-Emmanuel Monfoulet, Chandra Sekhar Chirumamilla, Ken Declerck, Maija Lahtela-Kakkonen, Clarissa Gerhäuser, Sylvain Claude, Wim Vanden Berghe, Dragan Milenkovic, Annette M. van de Sandt, Christine Morand, Marc W. Merx, Simone Gorressen, Malte Kelm

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-33959-x⟩
Scientific reports, vol 8, iss 1
Scientific reports
2nd COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives . 1 (8), 2017; 2. COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives, Thessalonique, GRC, 2017-09-20-2017-09-21
2. COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives
2. COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives, Sep 2017, Thessalonique, Greece. 2017
Scientific Reports 1 (8), . (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
2. COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives, Sep 2017, Thessalonique, Greece. Scientific Reports, 8 (1), 2017, 2nd COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives. ⟨10.1038/s41598-018-33959-x⟩
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-33959-x⟩

Presented at 2. COST POSITIVe Scientific Workshop on « Omics breakthroughs in the Health effects of plant food bioactives ; Thessalonique (Grèce) - (2017-09-20 - 2017-09-21) / Workshop (Prodinra 408917); International audience; Although vasculo-pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59faa3d1809ecc6138a3b50643bb3eb9
https://hal.inrae.fr/hal-02629289