Výsledky vyhledávání - "Chandra B. Louise"

Specific Interaction of Escherichia coli 0157:H7-Derived Shiga-like Toxin II with Human Renal Endothelial Cells

Publikováno v: Journal of Infectious Diseases. 172:1397-1401

In Escherichia coli O157:H7 foodborne infections of humans, the Shiga-like toxins (SLTs) are thought to be the cause of life-threatening vascular complications, including acute renal disease known as hemolytic uremic syndrome or HUS. As virtually all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f871ddec60efae17d25c6bea0d2198d3
https://doi.org/10.1093/infdis/172.5.1397

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Shiga toxin-associated hemolytic uremic syndrome: effect of sodium butyrate on sensitivity of human umbilical vein endothelial cells to Shiga toxin

Autor: B Boyd, Tom G. Obrig, C A Lingwood, S A Kaye, Chandra B. Louise

Publikováno v: Infection and Immunity. 63:2766-2769

Escherichia coli O157:H7-related vascular damage such as hemolytic uremic syndrome is believed to require the Shiga-like toxins. This study demonstrated that sodium butyrate sensitized human umbilical vein endothelial cells to Shiga toxin and increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68966e6142a70cd4021152cbbe774c86
https://doi.org/10.1128/iai.63.7.2766-2769.1995

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Binding of [125I]Shiga-like Toxin-1 to Human Endothelial Cells: Implications for the Pathogenesis of Shiga Toxin-associated Hemolytic Uremic Syndrome

Autor: Tom G. Obrig, Peter J. Del Vecchio, David J. Culp, Chandra B. Louise, Timothy Moran, C A Lingwood

Publikováno v: Endothelium. 3:159-170

Renal glomerular endothelial cell damage is a hallmark of Shiga toxin-associated hemolytic uremic syndrome (HUS) following bacillary dysentery in humans. This study examined the binding of [125I]Shiga-like toxin-1 (SLT-I) to human umbilical vein endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::522bb297c48defb73f1b0e7c650b7f2c
https://doi.org/10.3109/10623329509053392

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Human Renal Microvascular Endothelial Cells as a Potential Target in the Development of the Hemolytic Uremic Syndrome as Related to Fibrinolysis Factor Expression, in Vitro

Autor: Chandra B. Louise, Tom G. Obrig

Publikováno v: Microvascular Research. 47:377-387

Renal glomerular microvascular endothelial cell damage is characteristic of Shiga toxin-associated hemolytic uremic syndrome (HUS). An impaired renal fibrinolysis may be responsible for renal microvascular fibrin accumulation during the course of HUS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedab5825c798695b28599ba47da6f38
https://doi.org/10.1006/mvre.1994.1030

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Direct Cytotoxic Effects of Hemorrhagic Toxins from Crotalus ruber ruber and Crotalus atrox on Human Vascular Endothelial Cells, in Vitro

Autor: Tom G. Obrig, Anthony T. Tu, Nobu Mori, Timothy Moran, Chandra B. Louise

Publikováno v: Microvascular Research. 46:412-416

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc21bf7a138d68e3b0f299a4b7a29f5b
https://doi.org/10.1006/mvre.1993.1065

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Shiga toxin-associated hemolytic uremic syndrome: interleukin-1 beta enhancement of Shiga toxin cytotoxicity toward human vascular endothelial cells in vitro

Autor: Tom G. Obrig, B Boyd, C A Lingwood, S A Kaye, Chandra B. Louise

Publikováno v: Infection and Immunity. 61:3886-3891

Development of hemolytic uremic syndrome (HUS) after infection by Shigella dysenteriae 1 or enterohemorrhagic Escherichia coli has been associated with the production of Shiga toxins (verotoxins). The putative target of Shiga toxins in HUS is the ren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df97b3f5edd62736052814c7e9a849d
https://doi.org/10.1128/iai.61.9.3886-3891.1993

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Endothelial heterogeneity in Shiga toxin receptors and responses

Autor: Chandra B. Louise, C A Lingwood, B Boyd, L Barley-Maloney, Tom G. Obrig, T O Daniel

Publikováno v: Journal of Biological Chemistry. 268:15484-15488

This study addresses the basis for regional microvascular susceptibility to bacterial toxins implicated in hemolytic uremic syndrome. The results indicate a relationship between the degree of Shiga toxin sensitivity of human endothelial cells from di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09e036ee3bb8572ef682113b88365dcd
https://doi.org/10.1016/s0021-9258(18)82282-7

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Sensitization of human umbilical vein endothelial cells to Shiga toxin: involvement of protein kinase C and NF-kappaB

Autor: Tom G. Obrig, Chandra B. Louise, Mark C. Tran

Publikováno v: Infection and immunity. 65(8)

Infection of humans with Shiga toxin-producing Escherichia coli O157:H7 and Shigella dysenteriae 1 is strongly associated with vascular endothelial cell damage and the development of hemolytic-uremic syndrome. The cytotoxic effect of Shiga toxins on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4248f3e3125833139b3594fd07a25ba
https://pubmed.ncbi.nlm.nih.gov/9234795

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Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of shiga toxin and lipopolysaccharide (endotoxin) on human vascular endothelial cells in vitro

Autor: Tom G. Obrig, Chandra B. Louise

Publikováno v: Infection and immunity. 60(4)

This study explores the in vitro relationship between Shiga toxin-producing Shigella spp. and Escherichia coli and the development of vascular complications in humans following bacillary dysentery. We propose that lipopolysaccharide (LPS; endotoxin)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150349e21c78f6fe28453b4543aebaa5
https://pubmed.ncbi.nlm.nih.gov/1548077

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