Bridging dolutegravir clinical viral response across doses and formulations using model-based exposure-response analysis in pediatrics.

Autor: Chandasana H; Clinical Pharmacology Modeling & Simulation, GSK, Collegeville, Pennsylvania, USA., Hayes S; ICON, Reading, UK., Buchanan AM; ViiV Healthcare, Durham, NC., Brothers C; ViiV Healthcare, Durham, NC., Wiznia A; Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY., Bartlett M; Frontier Science Foundation, Boston, MA., Popson S; Frontier Science Foundation, Boston, MA., Townley E; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., George K; Family Health International 360, Durham, NC., Vavro C; ViiV Healthcare, Durham, NC., Ruel T; University of California, San Francisco, San Francisco, CA., Acosta EP; University of Alabama at Birmingham, Birmingham, Alabama, USA., Singh R; Clinical Pharmacology Modeling & Simulation, GSK, Collegeville, Pennsylvania, USA.

Publikováno v: AIDS (London, England) [AIDS] 2024 Jul 15; Vol. 38 (9), pp. F11-F18. Date of Electronic Publication: 2024 May 17.

Population Pharmacokinetic Analysis of Dolutegravir in Treatment-Experienced Adults Living with HIV-1.

Autor: Chandasana H; GSK, Collegeville, PA, USA., Bush M; ViiV Healthcare, Durham, NC, USA., Ait-Khaled M; ViiV Healthcare Ltd, Brentford, UK., Wynne B; ViiV Healthcare, Durham, NC, USA., Min S; ViiV Healthcare, Durham, NC, USA., Mehta R; GSK, Durham, NC, USA.

Publikováno v: Journal of clinical pharmacology [J Clin Pharmacol] 2024 Nov; Vol. 64 (11), pp. 1407-1418. Date of Electronic Publication: 2024 Jul 16.

Advancing research and development of anti-infectives for children with a focus on antiretroviral therapy: A clinical development perspective.

Autor: Buchanan AM; ViiV Healthcare, Durham, NC, USA., Bekker A; Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa., Chandasana H; GSK, Collegeville, PA, USA., DeMasi R; ViiV Healthcare, Durham, NC, USA., Lulic Z; GSK, Brentford, Middlesex, UK., Ernest T; GSK, Ware, Hertfordshire, UK., Brothers C; ViiV Healthcare, Durham, NC, USA., Min S; ViiV Healthcare, Durham, NC, USA., Ruel T; Division of Pediatric Infectious Diseases and Global Health, Department of Pediatrics, University of California, San Francisco, CA, USA., Tan LK; ViiV Healthcare, Brentford, Middlesex, UK. Electronic address: lionel.x.tan@viivhealthcare.com.

Publikováno v: International journal of antimicrobial agents [Int J Antimicrob Agents] 2024 Oct; Vol. 64 (4), pp. 107306. Date of Electronic Publication: 2024 Aug 13.

Dosing Cefazolin for Surgical Site Infection Prophylaxis in Adolescent Idiopathic Scoliosis Surgery: Intermittent Bolus or Continuous Infusion?-A Pilot Study.

Autor: Yu Y; Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA.; Drug Development, Clinical Pharmacology, Boehringer Ingelheim, Ridgefield, CT 06810, USA., Dooley FC; Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Woods A; Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Gunnett A; Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Chandasana H; Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA.; Clinical Pharmacology, Modeling, and Simulation, Glaxo-Smith-Kline, Collegeville, PA 19426, USA., Amini E; Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA.; Department of Clinical Pharmacology, Gilead Sciences, Foster City, CA 94404, USA., Garvan C; Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Ihnow S; Department of Orthopaedic Surgery & Sports Medicine, University of Florida College of Medicine, Gainesville 32610, FL, USA., Blakemore LC; Pediatric Specialists of Virginia, Fairfax, VA 22031, USA., Sangari T; Department of Anesthesiology, University of California at San Francisco, Oakland, CA 94609, USA., Seubert CN; Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.

Publikováno v: Journal of clinical medicine [J Clin Med] 2024 Jun 16; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 16.

Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents.

Autor: Chandasana H; Clinical Pharmacology, Modeling and Simulation, GSK, 1250 South Collegeville Road, Collegeville, PA, 19406, USA. hardik.x.chandasana@gsk.com., Thapar M; ICON, Reading, UK., Hayes S; ICON, Reading, UK., Baker M; ViiV Healthcare, Nyon, Switzerland., Gibb DM; Medical Research Council Clinical Trials Unit at University College London, London, UK., Turkova A; Medical Research Council Clinical Trials Unit at University College London, London, UK., Ford D; Medical Research Council Clinical Trials Unit at University College London, London, UK., Ruel T; University of California, San Francisco, San Francisco, CA, USA., Wiznia A; Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Fairlie L; Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa., Bwakura-Dangarembizi M; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Mujuru H; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Alvero C; Frontier Science Foundation, Brookline, MA, USA., Farhad M; Frontier Science Foundation, Brookline, MA, USA., Hazra R; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Townley E; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Buchanan A; ViiV Healthcare, Durham, NC, USA., Bollen P; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Waalewijn H; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Colbers A; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Burger D; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Acosta EP; University of Alabama at Birmingham, Birmingham, AL, USA., Singh R; Clinical Pharmacology, Modeling and Simulation, GSK, 1250 South Collegeville Road, Collegeville, PA, 19406, USA.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2023 Oct; Vol. 62 (10), pp. 1445-1459. Date of Electronic Publication: 2023 Aug 21.