Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Autor: Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p

Externí odkaz: https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Autor: Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux

Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.4444. ⟨10.1038/s41467-022-32130-5⟩

During the early stages of Alzheimer’s disease (AD) in both mouse models and human patients, soluble forms of Amyloid-β 1–42 oligomers (Aβ42o) trigger loss of excitatory synapses (synaptotoxicity) in cortical and hippocampal pyramidal neurons (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460af2ea012485e058110bf60eec2fce
https://pubmed.ncbi.nlm.nih.gov/35915085

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Autor: Helen I. Woodroof, Matthias Trost, Miratul M. K. Muqit, Chandana Kondapalli, Brian D. Dill, Robert Gourlay, James B. Procter, Aymelt Itzen, Yu-Chiang Lai, Mark Peggie, Olga Corti, Ronny Lehneck, David G. Campbell, Thomas Macartney, Jean-Christophe Corvol

Publikováno v: The EMBO Journal
EMBO Journal
EMBO Journal, EMBO Press, 2015, 34 (22), pp.2840-2861. 〈10.15252/embj.201591593〉
EMBO Journal, 2015, 34 (22), pp.2840-2861. ⟨10.15252/embj.201591593⟩
EMBO Journal, EMBO Press, 2015, 34 (22), pp.2840-2861. ⟨10.15252/embj.201591593⟩

International audience; Mutations in the PTEN-induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is activated by mitochondrial depolarisation and phosphorylates serine 65 (Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bccdd68a5f96dfe2b8a8b7d59e9b735
http://europepmc.org/articles/PMC4654935

The Linker Region in Receptor Guanylyl Cyclases Is a Key Regulatory Module

Autor: Kabir H. Biswas, Sayanti Saha, Sandhya S. Visweswariah, Chandana Kondapalli, Nishitha Isloor

Publikováno v: Journal of Biological Chemistry. 284:27135-27145

Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The intracellular domain of these receptors is composed of a kinase homology domain (KHD), a linker of ∼

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44782f5e9a886180d030b96cd14cec5f
https://doi.org/10.1074/jbc.m109.020032

The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C

Autor: Sayanti, Saha, Kabir Hassan, Biswas, Chandana, Kondapalli, Nishitha, Isloor, Sandhya S, Visweswariah

Publikováno v: The Journal of biological chemistry. 284(40)

Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The intracellular domain of these receptors is composed of a kinase homology domain (KHD), a linker of app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25b73810e21f6a729a769474f01d85cd
https://pubmed.ncbi.nlm.nih.gov/19648115